itpr1
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  • Official Full Name
  • Itpr1 inositol 1,4,5-trisphosphate receptor 1
  • Synonyms
  • ITPR1; inositol 1,4,5-trisphosphate receptor 1; inositol 1,4,5-trisphosphate receptor type 1; IP3R 1; insP3R1; IP3 receptor; opisthotonus; InsP3R type I; protein PCD-6; InsP> 3< R type I; type 1 InsP3 receptor; Purkinje cell protein 1; inositol 1,4,5-triphosphate receptor 1; type 1 inositol 1,4,5-trisphosphate receptor; inositol 1,4,5-trisphosphate-binding protein P400; opt; Ip3r; P400; Pcp1; IP3R1; Pcp-1; D6Pas2; InsP3R; Itpr-1; Gm10429; ENSMUSG00000072853;
Cat.#:ITPR1-4945HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ITPR1 Protein, GST-tagged
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Cat.#:ITPR1-8389MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ITPR1 Protein
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Cat.#:ITPR1-4075CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ITPR1
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Involved Pathway

ITPR1 involved in several pathways and played different roles in them. We selected most pathways ITPR1 participated on our site, such as Calcium signaling pathway, cGMP-PKG signaling pathway, Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITPR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Calcium signaling pathway
ITPKB; SLC8A1; CHRM5B; ADRA1BB; ADRB3; GRIN1; AVPR1A; ADORA2AA; MLCK2; NTSR1
cGMP-PKG signaling pathway
MYLK3; ATP1A4; ATP1B2; VDAC3; NFATC3; GTF2I; GNAQ; GUCY1B3; ITPR3; CALML3
Phosphatidylinositol signaling system
PIP5K1AB; PRKCB; PRKCG; PIP5K1AA; PLCD1B; CALM2A; PIK3C3; CALM; INPP5J; INPP1
Oocyte meiosis
CPEB2; CUL1; PRKACA; SLK; CALM3A; CDC20; PPP1CC; CCNB2; INS2; PPP3R1
Vascular smooth muscle contraction
GNA12A; PPP1CA; GNA12; PRKACB; AGTR1B; PLCB1; PPP1R14AB; PRKACBA; CALM3; CALCRLA
Gap junction
PRKG2; GNA11B; TUBB5; TUBA1L2; PRKACA; HRASA; PDGFRB; TJP1; ADCY1B; PDGFD
Platelet activation
ITGA2; GUCY1B3; PIK3CB; PLA2G4D; STIM1; VWF; PIK3CG; VASP; TBXAS1; PRKACB
Circadian entrainment
PRKACG; CALM4; RYR2; GNG4; GRIN2D; CAMK2G; PLCB1; GNAS; KCNJ5; GNG12
Long-term potentiation
MAP2K1; ARAF; RAF1; PRKACB; CALM1; PRKACG; CAMK2A; ITPR3; CAMK2G; RPS6KA1
Retrograde endocannabinoid signaling
MAPK11; GABRP; GNAI3; GNAQ; GABRR3; GABRG2; GNG2; GNB2; GRIA1; GRIA2
Glutamatergic synapse
SLC1A2; PRKACA; PLCB3; GNAI1; SHANK3; HOMER3; GNG10; SHANK2; GNAS; GNG3
Cholinergic synapse
KCNJ3; FYN; MAP2K1; KCNQ4; CHRM2; PRKACG; PLCB4; ITPR3; GNAQ; PIK3R1
Serotonergic synapse
PRKCG; KCND2; CYP2C50; NRAS; GNG5; HTR1B; PRKACG; PLCB4; ALOX5; ITPR3
Dopaminergic synapse
MAPK13; PPP3CA; PPP2CA; GNAI1; PLCB2; DRD1; PRKCA; MAOA; GNAL; KCNJ5
Long-term depression
CRH; GNAZ; PPP2CB; GNAO1; IGF1R; GUCY1A3; PLA2G4F; GUCY1B3; GRIA3; PLCB3
Inflammatory mediator regulation of TRP channels
PIK3R1; MAP2K3; MAP2K6; TRPV1; PRKCG; PIK3R2; CYP2C39; F2RL1; NTRK1; CYP2C70
GnRH signaling pathway
CALM; CDC42L2; HRASB; CAMK2D2; PRKACAA; ADCY2B; MAP2K6; PRKCDA; FSHB; MAP2K2
Estrogen signaling pathway
HSPA1B; HSPA2; HSP90B1; PLCB2; CALML3; Adcy4; FOS; GNAQ; HSPA1A; PIK3CD
Thyroid hormone synthesis
PLCB1; GPX2; PRKACB; TPO; ATP1A4; ASGR2; CREB3L3; CREB3L1; GPX7; ITPR3
Oxytocin signaling pathway
FOS; CAMK4; PIK3R5; MYLK4; CACNA2D4; PPP3R2; NRAS; KCNJ14; CACNA2D2; PRKCB
Glucagon signaling pathway
G6PC3; GYS2; PRKAG2; PPP3CC; PPARA; ACACB; CALML3; PHKG1; PGAM1; SIRT1
Renin secretion
PPP3R2; PDE3A; PTGER4; PRKACG; PLCB4; AGTR1A; CALM4; REN2; PPP3R1; CLCA2
Aldosterone synthesis and secretion
ATF2; ADCY1; GNA11; CALML3; LDLR; NR4A1; PRKCE; CYP11A1; GNAS; STAR
Salivary secretion
ATP1A3; AQP5; CALM4; CALML3; ATP1B1; ATP2B4; BST1; CALM2; ATP1B2; SLC9A1
Gastric acid secretion
CAMK2G; ITPR1; PRKACB; ATP1A1; PLCB4; SSTR2; EZR; PRKCG; PLCB2; ATP4B
Pancreatic secretion
CELA3A; PRSS1; FXYD2; ATP1A3; PLA2G12B; PNLIP; KCNQ1; PRKCA; BST1; RAB8A
Alzheimers disease
NDUFC1; BACE1; NDUFV1; NDUFA1; CAPN2; PSEN2; NDUFS7; MAPT; UQCRC1; NDUFA2
Huntingtons disease
VDAC3; NDUFA11; TAF4B; SOD2; NDUFS6; GRIN2B; COX6C; TBPL1; Atp5g2; DNAL4
Proteoglycans in cancer
ANK2; CD44; HSPB2; PRKACG; WNT16; AKT2; PPP1R12B; WNT7A; TLR4; WNT2B

Protein Function

ITPR1 has several biochemical functions, for example, calcium channel activity, calcium channel inhibitor activity, inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ITPR1 itself. We selected most functions ITPR1 had, and list some proteins which have the same functions with ITPR1. You can find most of the proteins on our site.
Function
Related Protein
Function calcium channel activity
Related Protein PKD2L2; TRPM1; TRPC5; P2RX1; PDE2A; ORAI1B; AKR1C1; CACNG2B; TRPC6A; TRPM4
Function calcium channel inhibitor activity
Related Protein SLC30A1; AMBP; SLC30A1B; SLC30A1A; TNNI3; CCDC109B; ITPR1; FKBP1AB; FKBP1B; PHPT1
Function inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
Related Protein ITPR2; ITPR1; AKR1C1; ITPR3
Function intracellular ligand-gated calcium channel activity
Related Protein ITPR3; ITPR1; TRPA1; AKR1C1; RYR2
Function ion channel activity
Related Protein SCN8AB; TRPM1; NALCN; TRPM4A; CNGA4; TRPM1B; KCNC1A; CHRNB1L; SCN8AA; P2RX3B
Function phosphatidylinositol binding
Related Protein PLD1; PLD2; SNX33; SNX27; ITPR1; SNX4; SNX10A; SNX18A; SNX9; SNX15
Function protein C-terminus binding
Related Protein ERCC6; CALCOCO1; TAX1BP3; ITGB3BP; ERBB2; HIC2; DLG3; ATP1B1; ATP2A2; AXIN1
Function protein binding
Related Protein ZKSCAN17; HSPA14; CENPH; OSTC; NRSN1; KRT15; IFRD2; ITGAV; UBE2G2; STARD3
Function protein complex binding
Related Protein NCK2; PRMT5; WRN; CRHR1; PLK2; PPP1R9B; UGT1A6B; PPIB; TWF1; ITGB1BP1
Function protein phosphatase binding
Related Protein DLG4; AP3B1; HSF4; TRAF2; FLT4; DRD1A; STAT6; PARD3; HSP90B1; PPARG

Interacting Protein

ITPR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITPR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITPR1.
Erp44; Hspa9; Htt; Vdac1; Aco2; Ppif; Hap1; Hap1; PRKACB; HTT; CALM1; Ywhae; Ywhaz

ITPR1 Related Articles

Jarius, S; Scharf, M; et al. Antibodies to the inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) in cerebellar ataxia. Journal of Neuroinflammation 11:-(2014).
Sarachana, T; Hu, VW; et al. Genome-wide identification of transcriptional targets of RORA reveals direct regulation of multiple genes associated with autism spectrum disorder. MOLECULAR AUTISM 4:-(2013).