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ITPR1

  • Official Full Name

    Itpr1 inositol 1,4,5-trisphosphate receptor 1

  • Synonyms

    ITPR1; inositol 1,4,5-trisphosphate receptor 1; inositol 1,4,5-trisphosphate receptor type 1; IP3R 1; insP3R1; IP3 receptor; opisthotonus; InsP3R type I; protein PCD-6; InsP> 3< R type I; type 1 InsP3 receptor; Purkinje cell protein 1; inositol 1,4,5-triphosphate receptor 1; type 1 inositol 1,4,5-trisphosphate receptor; inositol 1,4,5-trisphosphate-binding protein P400; opt; Ip3r; P400; Pcp1; IP3R1; Pcp-1; D6Pas2; InsP3R; Itpr-1; Gm10429; ENSMUSG00000072853;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • E.coli
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ITPR1-4945H Recombinant Human ITPR1 Protein, GST-tagged Wheat Germ GST
Human ITPR1-2346H Recombinant Human ITPR1 Protein, His-tagged E.coli N-His Gly112-Val287
Mouse ITPR1-8389M Recombinant Mouse ITPR1 Protein Mammalian Cell His
Mouse ITPR1-4655M Recombinant Mouse ITPR1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ITPR1-4655M-B Recombinant Mouse ITPR1 Protein Pre-coupled Magnetic Beads HEK293
Chicken ITPR1-4075C Recombinant Chicken ITPR1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ITPR1 Related Articles

ITPR1 involved in several pathways and played different roles in them. We selected most pathways ITPR1 participated on our site, such as Calcium signaling pathway, cGMP-PKG signaling pathway, Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITPR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Calcium signaling pathwayAdcy4;MYLK3;PLCE1;TACR1A;ADRA1B;PDE1B;PRKCB;PPIF;GRIN2C
cGMP-PKG signaling pathwayNPPB;ATF4;SLC8A1;PPP1R12A;LOC100328615;GTF2IRD1;CREB3L2;MAP2K2;MYH7
Phosphatidylinositol signaling systemCALM2B;CALM1;CALM4;MTMR1B;MTMR7A;DGKE;CALM3;PLCB4;ITPR3
Oocyte meiosisPPP2R1A;IGF1RB;PKMYT1;PPP3CC;ADCY1B;FBXO43;STAG3;PPP1CAB;PPP2R5A
Vascular smooth muscle contractionNPR2;PLA2G10;PPP1R14AB;PPP1CA;PRKCDA;PLA2G4F;CYP4A10;PRKCD;MAPK3
Gap junctionDRD1A;TUBA8L;DRD2B;GNA11A;GRM1;PDGFRB;MAP2K2A;RAF1;PDGFD
Platelet activationMYL12A;GNAI3;PRKG1;TBXA2R;PIK3CG;ROCK1;PIK3CD;PLCG2;PIK3R1
Circadian entrainmentGRIA3;PRKCG;GNAO1;NOS1;GNG3;GNG4;GNG11;GNB2;MTNR1A
Long-term potentiationRPS6KA2;PLCB2;GRIN2B;RPS6KA1;PPP3R2;PPP1CB;PPP3CA;GRM5;PRKCG
Retrograde endocannabinoid signalingMAPK13;GNG13;PLCB2;GABRG1;GNB3;DAGLB;GABRR2;SLC17A6;GABRG2
Glutamatergic synapseAdcy4;PPP3R1;GRIN2D;GRIA3;PRKCG;GRIN1;TRPC1;PRKACA;GRIK2
Cholinergic synapseNRAS;CHRNB4;FYN;KCNJ12;CHRM4;PIK3CB;GNG5;GNB3;KCNQ5
Serotonergic synapseCYP2D26;CYP2C39;SLC18A1;CYP2J5;PRKCG;GNAS;MAPK1;PLA2G4C;PLA2G4F
Dopaminergic synapseCALM1;GRIA3;KCNJ9;GSK3A;PRKACB;GNGT1;CLOCK;KIF5A;PPP2R5D
Long-term depressionGNAI3;GRIA3;GNAS;ARAF;MAPK1;PPP2R1A;GNAQ;MAP2K2;PLCB2
Inflammatory mediator regulation of TRP channelsCYP2C39;MAP2K3;PIK3CA;TRPM8;CAMK2G;BDKRB2;PRKCH;PLCG1;CYP2C54
GnRH signaling pathwayPRKACG;PRKACBB;PRKCB;MAP2K1;PTK2B;PLA2G4D;MMP14A;PLD1A;MMP14
Estrogen signaling pathwayHSP90AB1;KCNJ5;SHC2;FKBP5;GNAI1;GABBR1;KCNJ6;PLCB1;GABBR2
Thyroid hormone synthesisGPX7;CREB5;ATP1A2;CREB3L3;TSHR;PRKACG;HSP90B1;ATP1B2;ITPR1
Oxytocin signaling pathwayPRKAB1;ROCK1;PRKCB;CACNG6;PRKAG1;PIK3CG;GNAI2;NFATC2;MYLK4
Renin secretionPRKACG;PRKACB;PPP3CA;CLCA4;ACE;AGTR1A;CLCA1;PTGER4;GNAI3
Aldosterone synthesis and secretionITPR3;CAMK1D;CYP11B2;CREB3L2;ADCY3;HSD3B1;HSD3B6;CACNA1H;GNAQ
Salivary secretionAdcy4;PRKCG;AMY1B;CALML5;CD38;ATP1A2;CST3;PMAP-36;LPO
Gastric acid secretionCAMK2G;ACTB;MYLK;ITPR1;SLC9A1;CALM1;ATP1A4;PRKCB;PRKCA
Pancreatic secretionCLCA1;CELA2A;PRSS1;PLCB2;CLCA5;FXYD2;ATP2A3;KCNQ1;CPB2
Alzheimers diseaseNAE1;ATP5H;TNFRSF1A;COX7B2;APOE;CALM3;ATP2A1;IL1B2;UQCRH
Huntingtons diseaseSOD1;NDUFAB1;UQCRFS1;NDUFB6;EP300;NDUFC2;POLR2E;TFAM;TRP53
Proteoglycans in cancerHIF1A;MRAS;PTPN11;HSPG2;FZD7;PDPK1;Fzd4;AKT1;ACTG1

ITPR1 has several biochemical functions, for example, calcium channel activity, calcium channel inhibitor activity, inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ITPR1 itself. We selected most functions ITPR1 had, and list some proteins which have the same functions with ITPR1. You can find most of the proteins on our site.

Function Related Protein
calcium channel activityTRPC2B;CACNG2A;PKD2L1;CHRNA9;TRPC5A;SLC24A5;TMEM37;TRPV5;TRPV6
calcium channel inhibitor activitySTX1A;SLC30A1B;PHPT1;TNNI3;SLC30A1A;FKBP1AA;AMBP;CCDC109B;FKBP1B
inositol 1,4,5-trisphosphate-sensitive calcium-release channel activityITPR3;ITPR1;AKR1C1;ITPR2
intracellular ligand-gated calcium channel activityTRPA1;AKR1C1;RYR2;ITPR1;ITPR3
ion channel activityDDX1;GRIA2A;TRPM5;CHRNB3A;KCNV2B;TRPC5A;CLCN4-2;KCNG4A;TRPC6A
phosphatidylinositol bindingZCCHC2;PLD2;NCF1;SNX33;MITD1;SNX16;SNX10A;SNX27A;RPS6KC1
protein C-terminus bindingHRAS;ATXN2;SIAH1A;VAMP2;TJP2;HESX1;HSPB7;STIP1;BLOC1S2
protein bindingSETD8;MIS18BP1;C9orf78;CTTNBP2NL;SCYL3;RNF20;CASP8;CSPG5;GRM6
protein complex bindingKIF11;GNB2;NASP;Ctsl;FYB;RIPK3;KAT6B;FLCN;LRP2
protein phosphatase bindingJAK1;PPARG;ERBB2;PPP1R3C;DLG3;SHOC2;CDH2;AP3B1;DLG4

ITPR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITPR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITPR1.

Erp44; Hspa9; Htt; Vdac1; Aco2; Ppif; Hap1; Hap1; PRKACB; HTT; CALM1; Ywhae; Ywhaz

Jarius, S; Scharf, M; et al. Antibodies to the inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) in cerebellar ataxia. Journal of Neuroinflammation 11:-(2014).
Sarachana, T; Hu, VW; et al. Genome-wide identification of transcriptional targets of RORA reveals direct regulation of multiple genes associated with autism spectrum disorder. MOLECULAR AUTISM 4:-(2013).
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