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ITPR3

  • Official Full Name

    inositol 1,4,5-trisphosphate receptor, type 3

  • Overview

    Inositol 1,4,5-triphosphate receptor, also known as IP3R or InsP3R, is a member of the intracellular calcium release channel family and is located in the endoplasmic reticulum. IP3R functions as a Ca2+ release channel for intracellular stores of calcium i
  • Synonyms

    ITPR3; inositol 1,4,5-trisphosphate receptor, type 3; inositol 1,4,5 triphosphate receptor, type 3; inositol 1,4,5-trisphosphate receptor type 3; IP3R3; insP3R3; IP3 receptor; type 3 InsP3 receptor; inositol 1,4,5-triphosphate receptor, type 3; IP3R; FLJ3;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • N
  • GST
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ITPR3-1701H Recombinant Human ITPR3 Protein, His&GST-tagged E.coli N-His&GST Phe2389-Asp2496
Mouse ITPR3-8391M Recombinant Mouse ITPR3 Protein Mammalian Cell His
Mouse ITPR3-4656M-B Recombinant Mouse ITPR3 Protein Pre-coupled Magnetic Beads HEK293
Mouse ITPR3-4656M Recombinant Mouse ITPR3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ITPR3-3127R Recombinant Rat ITPR3 Protein Mammalian Cell His
Rat ITPR3-2783R Recombinant Rat ITPR3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ITPR3-2783R-B Recombinant Rat ITPR3 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish ITPR3-6830Z Recombinant Zebrafish ITPR3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ITPR3 Related Articles

ITPR3 involved in several pathways and played different roles in them. We selected most pathways ITPR3 participated on our site, such as Calcium signaling pathway, cGMP-PKG signaling pathway, Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITPR3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Calcium signaling pathwayCALM1B;ATP2B2;GRM5;DRD1A;TACR3L;PRKACBB;STIM1A;SLC8A1B;PTK2B
cGMP-PKG signaling pathwayPIK3CG;PPP1CC;RGS2;PPP3R1;MAP2K2;SLC25A5;MYLK;PPP3CB;VDAC3
Phosphatidylinositol signaling systemPLCB4;PLCE1;PRKCBB;MTMR1;PTENB;CDS1;PI4K2A;PLCB2;PIK3R5
Oocyte meiosisCALM1B;ADCY1B;FBXO43;MOS;PPP3CC;YWHAE;SKP1;BTRC;IGF1RA
Vascular smooth muscle contractionARAF;RAF1B;PLA2G12A;MYL6B;GUCY1A3;KCNMB2;CALML3;CALM;ARHGEF11
Gap junctionPLCB3;MAP2K2A;TUBA1A;GNAI1;ADCY2B;DRD2A;KRAS;TUBA3B;TUBA3E
Platelet activationMAPK12;GUCY1B3;PIK3R3;VWF;GNAI3;GUCY1A3;LYN;SYK;P2RX1
Circadian entrainmentCAMK2A;GRIN1;GNG12;GRIN2A;CALM2;NOS1;FOS;Adcy4;GNGT1
Long-term potentiationPRKCA;PRKACA;PPP3R2;CALM3;PPP3CC;MAP2K2;GRIA1;HRAS;PLCB3
Retrograde endocannabinoid signalingMAPK1;GNG10;Adcy4;GRIA2;PLCB2;GNB4;GNG13;GABRD;GNB2
Glutamatergic synapsePRKCA;PRKACG;GRM7;SLC1A1;PLCB4;PPP3CA;GNAI1;GNAI2;GRM4
Cholinergic synapseKCNJ6;PRKCB;GNG13;ACHE;GNB2;CHRM5;PLCB4;GNGT2;GNG10
Serotonergic synapseKCNN2;GNB4;HTR6;TPH2;ALOX8;RAF1;ALOX12E;CYP4X1;HTR4
Dopaminergic synapseGNAI3;PPP2R2D;PLCB1;AKT1;PRKCB;CREB3L2;CALML5;PPP2R1A;PLCB4
Long-term depressionIGF1R;MAP2K2;PLCB3;CRH;GNAZ;PPP2CA;PPP1R17;PPP2CB;GNAI2
Taste transductionKCNB1;TAS2R114;TAS2R121;TAS2R134;GNB1;ALPHA-ENAC;TAS2R113;TAS2R7;PRKACG
Inflammatory mediator regulation of TRP channelsPPP1CA;CYP2J6;TRPV1;PIK3CA;CALM2;SRC;PLCG1;CAMK2G;PTGER2
Insulin secretionATP1B4;KCNN2;RIMS2;PCLO;PDX1;KCNMB2;ATP1A1;GCG;SLC2A2
GnRH signaling pathwayMAP2K2;MAPK3;CAMK2A;CAMK2G;EGFRA;GRB2B;PRKCDA;MAP2K4;MAP2K2A
Estrogen signaling pathwayPIK3R1;HSPA2;PIK3R2;GNAQ;CREB3L1;PRKACB;HSPA6;PIK3R5;GABBR2
Thyroid hormone synthesisATP1A4;CREB3L2;TG;ASGR1;ITPR3;GPX5;TSHB;SLC26A4;ATF4
Oxytocin signaling pathwayELK1;PPP3R1;PPP1R12A;MAP2K2;FOS;PLCB1;GNAS;GNAQ;MYLK3
Renin secretionPRKACG;GNAQ;AQP1;GNAI2;REN2;LOC100328615;CLCA3;CLCA5;PDE3A
Aldosterone synthesis and secretionCALM2;DDX1;CREB5;PRKACB;PLCB3;GNAQ;LIPE;CACNA1G;AKR1C1
Salivary secretionMUC7;ATP1B3;PRKG1;PRH2;PRKCB;STATH;CD38;CST3;CALML3
Gastric acid secretionCA2;PRKACA;KCNJ2;ATP4B;ATP1B1;ATP1B3;CAMK2A;KCNJ16;CAMK2B
Pancreatic secretionCELA2B;LOC780933;ATP2A1;ATP1B2;PNLIPRP2;PLA2G2D;SLC4A4;PRKCA;ATP1B3
Alzheimers diseaseCASP9;MME;UQCR11;COX5B;ATP5J;NDUFA11;NDUFB8;NDUFS2;CASP7
Proteoglycans in cancerARHGEF12;FLNC;TNF;RRAS2;CCND1;PIK3CA;FASLG;MAPK3;ANK2

ITPR3 has several biochemical functions, for example, calcium channel activity, calcium ion binding, inositol 1,3,4,5 tetrakisphosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITPR3 itself. We selected most functions ITPR3 had, and list some proteins which have the same functions with ITPR3. You can find most of the proteins on our site.

Function Related Protein
calcium channel activityCHRNA10;TRPC2;TRPC4B;TPCN1;RYR1;TRPC7B;CATSPER2;GRIN2B;CACNG1A
calcium ion bindingS100A16;EHD4;GSNB;CAPN8;C1R;SYT15;MEGF6;SYT5;CUBN
inositol 1,3,4,5 tetrakisphosphate bindingITPR3;ADAP2;SYT2;ADAP1;AKR1C1
inositol 1,4,5 trisphosphate bindingTRPC6;TRPC6A;TRPC3;PLCL1;CYTH2;TRPC7;TRPC2B;ITPR3;RPH3A
inositol 1,4,5-trisphosphate-sensitive calcium-release channel activityITPR1;ITPR3;AKR1C1;ITPR2
inositol hexakisphosphate bindingAKR1C1;ITPR3
intracellular ligand-gated calcium channel activityTRPA1;ITPR1;AKR1C1;RYR2;ITPR3
ion channel activityFXYD5;FXYD2;GRIN2A;NALCN;CHRNB3B;CLCN4-2;SCN12AA;KCNV2B;P2RX3B
phosphatidylinositol bindingHS1BP3;PASK;SH3PXD2AA;SNX17;ZCCHC2;AKR1C1;SH3YL1;SNX27A;SNX33
protein bindingPYROXD1;CDK8;ANXA9;FATE1;SNX9;TP53INP1;SARM1;PER2;PITX1

ITPR3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITPR3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITPR3.

Abcf1; Lrmp

MARANTO, AR; et al. PRIMARY STRUCTURE, LIGAND-BINDING, AND LOCALIZATION OF THE HUMAN TYPE-3 INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR EXPRESSED IN INTESTINAL EPITHELIUM. JOURNAL OF BIOLOGICAL CHEMISTRY 269:1222-1230(1994).
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