itpr3
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  • Official Full Name
  • inositol 1,4,5-trisphosphate receptor, type 3
  • Background
  • Inositol 1,4,5-triphosphate receptor, also known as IP3R or InsP3R, is a member of the intracellular calcium release channel family and is located in the endoplasmic reticulum. IP3R functions as a Ca2+ release channel for intracellular stores of calcium i
  • Synonyms
  • ITPR3; inositol 1,4,5-trisphosphate receptor, type 3; inositol 1,4,5 triphosphate receptor, type 3; inositol 1,4,5-trisphosphate receptor type 3; IP3R3; insP3R3; IP3 receptor; type 3 InsP3 receptor; inositol 1,4,5-triphosphate receptor, type 3; IP3R; FLJ3
Cat.#:ITPR3-8391MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ITPR3 Protein
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Cat.#:ITPR3-3127RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ITPR3 Protein
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Cat.#:ITPR3-6830ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ITPR3
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Involved Pathway

ITPR3 involved in several pathways and played different roles in them. We selected most pathways ITPR3 participated on our site, such as Calcium signaling pathway, cGMP-PKG signaling pathway, Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITPR3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Calcium signaling pathway
AGTR1B; ADORA2AA; ITPKA; HTR2C; ERBB3A; RYR1B; GNA15.4; ERBB3B; BDKRB1; CAMK2G
cGMP-PKG signaling pathway
KCNMB3; PPP1CB; PPP3R2; PRKCE; PIK3R2; PDE3A; MYLK4; CALM3; NFATC3; NPPB
Phosphatidylinositol signaling system
PI4K2A; INPP5KA; ITPKB; PIK3C2B; PIK3R3B; PI4KA; CALM2B; CDS2; PIP5K1C; PLCG1
Oocyte meiosis
PPP2R5E; PLK1; Adcy4; RPS6KA3; YWHABA; CDC20; CALM2A; CDC16; PPP2R5EA; PPP1R2P9
Vascular smooth muscle contraction
CALML5; RHOAA; CACNA1SB; ACTG2; GNA13A; PRKACBB; MLCK2; PRKACB; CALM1B; MYL9B
Gap junction
CSNK1DB; TUBA3B; PRKACA; TUBB2; TUBA4A; PRKCA; PRKCB; DRD2A; TUBA3C; PLCB1
Platelet activation
MYLK3; GNAI1; MYLK2; COL27A1; Adcy4; SRC; TBXA2R; PLA2G4C; PLCG2; LYN
Circadian entrainment
CAMK2B; MAPK3; GNG2; CALM2; ADCYAP1R1; CAMK2D; PRKG2; PER2; GNGT1; GRIN2D
Long-term potentiation
PPP3CB; GRIN1; GNAQ; GRIN2C; ITPR1; RPS6KA2; RPS6KA1; GRIN2D; PPP3CA; CALML5
Retrograde endocannabinoid signaling
GNG10; GABRE; GABRG2; PLCB1; ITPR3; MAPK1; GABRB2; GABRA3; GABRB3; PLCB2
Glutamatergic synapse
GRM8; SLC17A6; PPP3R1; GRIN2A; GRM4; SLC38A1; SLC17A8; SLC1A7; PRKACG; GNG8
Cholinergic synapse
PIK3CB; PIK3R3; GNAQ; PIK3R5; CHRM3; PLCB4; KCNJ2; MAPK1; GNB1; ITPR1
Serotonergic synapse
PTGS1; HTR1F; PRKACG; PTGS2; GNGT1; PRKCB; NRAS; PLCB3; PLA2G4F; ALOX8
Dopaminergic synapse
CAMK2A; KCNJ9; PRKCA; PPP2CB; PPP2R1B; PPP2R5A; MAPK10; CREB3L4; KIF5B; AKT1
Long-term depression
GUCY1A3; PLA2G4F; MAP2K2; GRM1; MAPK1; PLA2G4D; GRIA1; MAPK3; PRKCB; BRAF
Taste transduction
PLCB2; SCNN1G; TAS2R107; TAS2R129; GNB3; TAS1R3; TAS2R125; SCNN1B; ALPHA-ENAC; PRKACB
Inflammatory mediator regulation of TRP channels
GNAS; CYP2C50; PRKCQ; ALOX12E; CALM4; CYP2C54; PIK3CG; CYP2C37; PRKACA; IL1B
Insulin secretion
INS1; GNAQ; KCNN2; CAMK2D; ITPR3; FFAR1; STX1A; KCNN3; ATP1A4; GNAS
GnRH signaling pathway
HRASA; PRKCD; CALM2; PTK2BB; HRAS; MAP3K4; MAPK8A; CAMK2G1; MAP2K4B; CACNA1SB
Estrogen signaling pathway
PLCB2; GNAO1; CALM1; OPRM1; PRKCD; PLCB4; GPR30; PLCB1; HSPA1L; GNAQ
Thyroid hormone synthesis
ATP1A1; TG; PAX8; ATP1B3; Adcy4; PRKCB; CANX; PLCB4; GSR; DUOXA2
Oxytocin signaling pathway
CAMK2D; ACTB; RHOA; FOS; GNAI1; CACNA2D3; PRKAG1; CACNA2D4; PIK3R1; MAPK3
Glucagon signaling pathway
PRKAB1; CALM4; PLCB1; PRKAB2; SLC2A2; AKT2; PLCB2; PRKAA1; PDHA1; CRTC2
Renin secretion
CLCA1; REN2; CALML3; GNAS; PPP3CB; GNAQ; PRKACA; GNAI1; AQP1; CLCA3
Aldosterone synthesis and secretion
HSD3B2; ATF4; CACNA1H; ATF6B; CAMK1; AKR1C1; PRKD2; PLCB4; PRKCG; CAMK2G
Salivary secretion
ATP1A4; CALM2; CST4; KCNN4; PRKCG; CST3; CALM4; LYZ; BST1; PRKCA
Gastric acid secretion
PLCB1; KCNJ16; ATP4B; Slc4a2; KCNK2; ATP1A3; Adcy4; GNAI1; CAMK2A; ITPR1
Pancreatic secretion
CLCA3; PLA2G2A; CELA3B; PRSS2; RHOA; PRKCA; PLA2G12A; PRSS1; Car2; PLCB4
Alzheimers disease
COX4I2; SDHB; CASP8; MME; ATP5B; HSD17B10; PPP3R2; NDUFA3; NDUFB8; NDUFB7
Proteoglycans in cancer
ERBB2; PIK3R2; HGF; WNT8B; Fzd4; MDM2; ANK2; CD44; RRAS; PPP1R12B

Protein Function

ITPR3 has several biochemical functions, for example, calcium channel activity, calcium ion binding, inositol 1,3,4,5 tetrakisphosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITPR3 itself. We selected most functions ITPR3 had, and list some proteins which have the same functions with ITPR3. You can find most of the proteins on our site.
Function
Related Protein
Function calcium channel activity
Related Protein PKD2L2; TRPM6; CACNA1C; CATSPER2; CACNG7A; CACNA1DA; TRPC6A; PDE2A; TRPV2; CACNG8A
Function calcium ion binding
Related Protein DMP1; MFGE8B; PCDH2G7; PCDH18; PLA2G5; SNCB; MMP1; PLA2G10; PCDHAC2; EFCAB12
Function inositol 1,3,4,5 tetrakisphosphate binding
Related Protein AKR1C1; ADAP1; ITPR3; ADAP2; SYT2
Function inositol 1,4,5 trisphosphate binding
Related Protein PLCL1; AKR1C1; RPH3A; ITPR3; TRPC1; TRPC6; TRPC7A; TRPC2; TRPC7; TRPC6A
Function inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
Related Protein ITPR2; AKR1C1; ITPR3; ITPR1
Function inositol hexakisphosphate binding
Related Protein ITPR3; AKR1C1
Function intracellular ligand-gated calcium channel activity
Related Protein AKR1C1; ITPR1; RYR2; TRPA1; ITPR3
Function ion channel activity
Related Protein KCNB2; SCN11A; KCNS3A; CACNA1BA; KCNH1A; NALCN; GRIA2B; SCN12AA; P2RX4B; TRPV2
Function phosphatidylinositol binding
Related Protein SNX2; FCHO2; SNX4; SNX25; PIK3C2B; SH3PXD2AA; ESYT2; SLC12A9; SNX1B; SNX10B
Function protein binding
Related Protein KIR2DL1; C8orf74; HENMT1; FBXO33; NOP10; GAN; GOLGA8G; TIPIN; MAP1B; NMB

Interacting Protein

ITPR3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITPR3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITPR3.
Abcf1; Lrmp

ITPR3 Related Articles

MARANTO, AR; et al. PRIMARY STRUCTURE, LIGAND-BINDING, AND LOCALIZATION OF THE HUMAN TYPE-3 INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR EXPRESSED IN INTESTINAL EPITHELIUM. JOURNAL OF BIOLOGICAL CHEMISTRY 269:1222-1230(1994).