itsn1
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  • Official Full Name
  • intersectin 1 (SH3 domain protein)
  • Background
  • The protein encoded by this gene is a cytoplasmic membrane-associated protein that indirectly coordinates endocytic membrane traffic with the actin assembly machinery. In addition, the encoded protein may regulate the formation of clathrin-coated vesicles and could be involved in synaptic vesicle recycling. This protein has been shown to interact with dynamin, CDC42, SNAP23, SNAP25, SPIN90, EPS15, EPN1, EPN2, and STN2. Multiple transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been characterized so far.
  • Synonyms
  • ITSN1; intersectin 1 (SH3 domain protein); ITSN, SH3D1A; intersectin-1; human intersectin SH3 domain containing protein SH3P17; intersectin 1 short form variant 3; intersectin 1 short form variant; 11; intersectin short variant 12; MGC134948; MGC134949; S
Cat.#:ITSN1-16HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human ITSN1, GST-tagged
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Cat.#:ITSN1-28347THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ITSN1, His-tagged
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Cat.#:ITSN1-8395MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ITSN1 Protein
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Cat.#:Itsn1-7873RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Itsn1 protein, His & T7-tagged
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Cat.#:ITSN1-11829ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ITSN1
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Involved Pathway

ITSN1 involved in several pathways and played different roles in them. We selected most pathways ITSN1 participated on our site, such as Axon guidance, Cell death signalling via NRAGE, NRIF and NADE, Developmental Biology, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITSN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Axon guidance
MYL9; CSF2RB; LOC608458; DUSP10; GFRA1; NRP2; ARHGEF12; NEFLB; ANK2B; SDCBP
Cell death signalling via NRAGE, NRIF and NADE
KALRNB; ARHGEF9; ITGB3BP; ARHGEF18; CASP2; ARHGAP4; TIAM2; DCLRE1B; AKAP13; FGD4A
Developmental Biology
RHOAE; EFNA3; ARHGEF28; ST8SIA2; INSM1A; CACNG2; GDNF; EPHB3A; ARPC4; CFL1
EPH-Ephrin signaling
ACTR3; ARHGEF28; EFNB3B; EPHA2A; EFNB2A; EFNB3; ARPC2; CLTC; DNM1; ARPC1A
EPHB forward signaling
GRB7; EFNB1; EFNB3; ITSN1; EFNA5; EFNB2
EPHB-mediated forward signaling
ACTR2; EPHB3A; KALRNB; ACTR3; ARPC1B; CFL1; ARPC2; ARHGEF28; EFNB3B; KALRN
G alpha (12/13) signalling events
PLEKHG2; OBSCN; NET1; ECT2; RHOC; ARHGEF18A; ARHGEF18; ARHGEF1B; RHOB; KALRNB
GPCR downstream signaling
GPR65; CCL35.1; TAAR1; RGR; CRHR2; FGD2; GPR68; APPB; ARHGEF9; NMBB

Protein Function

ITSN1 has several biochemical functions, for example, Rho guanyl-nucleotide exchange factor activity, calcium ion binding, guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ITSN1 itself. We selected most functions ITSN1 had, and list some proteins which have the same functions with ITSN1. You can find most of the proteins on our site.
Function
Related Protein
Function Rho guanyl-nucleotide exchange factor activity
Related Protein KALRN; ARHGEF1A; ARHGEF7; NET1; DOCK9; VAV2; MCF2L; FGD; FGD1; VAV3B
Function calcium ion binding
Related Protein VLDLR; THBS4A; NID1; ITSN1; ACTN2B; SLC25A24L; PROS1; ANXA8; PCDH1GB9; PKD2L1
Function guanyl-nucleotide exchange factor activity
Related Protein DENND6A; SH2D3C; RASGEF1BA; PREX1; TAGAP; RAPGEF5B; ARHGEF17; DOCK8; TBXAS1; RASGRP2
Function kinase activator activity
Related Protein ITSN1; MOBKL1A; TAB1
Function proline-rich region binding
Related Protein GAREM; BAIAP2L1; BAIAP2; WBP4; CCND1; PFN1; CYLD; ABL1; APBB1; FAM59A
Function protein binding
Related Protein C6orf108; PI4K2A; PGAP2; KRTAP9-4; UBE2I; LYL1; MAP2K2; ZCCHC12; TNKS2; APOL1
Function protein complex scaffold
Related Protein KLHL17; CAV3; AKAP9; WWC2; ISCU; MPP7; ITSN1; SMARCD1; SLC9A3R1; SEPT2

Interacting Protein

ITSN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITSN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITSN1.
CBL; DNM2; WASL

ITSN1 Related Articles

Russo, A; Okur, MN; et al. Phosphatidylinositol 3-kinase, class 2 beta (PI3KC2 beta) isoform contributes to neuroblastoma tumorigenesis. CANCER LETTERS 359:262-268(2015).
Kong, XD; Liu, N; et al. Bioinformatics analysis of biomarkers and transcriptional factor motifs in Down syndrome. BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH 47:834-841(2014).