ivd
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  • Official Full Name
  • isovaleryl-CoA dehydrogenase
  • Background
  • Isovaleryl-CoA dehydrogenase (IVD) is a mitochondrial matrix enzyme that catalyzes the third step in leucine catabolism. The genetic deficiency of IVD results in an accumulation of isovaleric acid, which is toxic to the central nervous system and leads to isovaleric acidemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • IVD; isovaleryl-CoA dehydrogenase; isovaleryl CoA dehydrogenase , isovaleryl Coenzyme A dehydrogenase; isovaleryl-CoA dehydrogenase, mitochondrial; ACAD2; mitochondrial; FLJ12715; FLJ34849; Isovaleryl CoA dehydrogenase; Isovaleryl CoA dehydrogenase, mitochondrial; Isovaleryl Coenzyme A dehydrogenase; IVD_HUMAN
Cat.#:IVD-876MTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse IVD Protein (His31-Arg424), His-tagged
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Cat.#:IVD-2644HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human IVD Protein, MYC/DDK-tagged
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Cat.#:IVD-4942HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human IVD Protein, GST-tagged
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Cat.#:IVD-1943HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Isovaleryl Coenzyme A dehydrogenase, His-tagged
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Cat.#:IVD-29875THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IVD, His-tagged
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Cat.#:IVD-29876THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IVD, His-tagged
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Cat.#:IVD-8642HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human IVD, His tagged
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Cat.#:Ivd-8172MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ivd protein, His & T7-tagged
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Cat.#:IVD-3129RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat IVD Protein
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Cat.#:IVD-4390CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken IVD
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Cat.#:IVD-11536ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish IVD
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Cat.#:IVD-001HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human IVD cell lysate
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Involved Pathway

IVD involved in several pathways and played different roles in them. We selected most pathways IVD participated on our site, such as Branched-chain amino acid catabolism, Metabolic pathways, Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with IVD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Branched-chain amino acid catabolism
HIBADHA; DLD; IVD; BCKDK; HIBADH; PPM1K; ALDH9A1A.2; DBT
Metabolic pathways
KDSR; ACSS1; SCP2; TAT; PIGQ; CYP11C1; PLCB1; CPS1; NDUFA3; SAT2
Metabolism
IVD; MMADHC; SLC25A32A; CTHL; TREH; GCHFR; SLC35B3; NAMPT; CYP26A1; COX6B1
Metabolism of amino acids and derivatives
CKB; BCKDK; FTCD; OAZ2B; SLC25A15A; NQO1; SLC25A15; AZIN1B; IDO2; OAZ3
Valine, leucine and isoleucine degradation
ACAT1; ALDH7A1; HADHA; OXCT2B; MCCC2; AACS; AOX1; MUT; ACADS; ACADSB
leucine degradation
IVD

Protein Function

IVD has several biochemical functions, for example, electron carrier activity, fatty-acyl-CoA binding, flavin adenine dinucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IVD itself. We selected most functions IVD had, and list some proteins which have the same functions with IVD. You can find most of the proteins on our site.
Function
Related Protein
Function electron carrier activity
Related Protein ACOX3; SH3BGRL3; NCF1; ASPH; FDX1; ACADM; AKR1B1; AOX3; HSD17B6; TSTA3
Function fatty-acyl-CoA binding
Related Protein GCDHB; ACADL; ACBD5B; IVD; GCDHA; ACADM; ACBD6; SOAT1; ACOX1; ACBD5A
Function flavin adenine dinucleotide binding
Related Protein XDH; CYBB; SQLEA; KDM1A; SQLE; DUS4L; ACADVL; MTHFR; MAOB; GCDH
Function isovaleryl-CoA dehydrogenase activity
Related Protein IVD
Function oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor
Related Protein ACOX3; ACADSB; GCDHA; ACAD9; ACOXL; ACAD8; GCDHB; ACADVL; IVD; ACADM

Interacting Protein

IVD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IVD here. Most of them are supplied by our site. Hope this information will be useful for your research of IVD.
ssuA; SIRT4

IVD Related Articles

Vashist, SK; Schneider, EM; et al. Rapid sandwich ELISA-based in vitro diagnostic procedure for the highly-sensitive detection of human fetuin A. BIOSENSORS & BIOELECTRONICS 67:73-78(2015).
Koerner, JD; Markova, DZ; et al. Differential Gene Expression in Anterior and Posterior Annulus Fibrosus. SPINE 39:1917-1923(2014).