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IVD

  • Official Full Name

    isovaleryl-CoA dehydrogenase

  • Overview

    Isovaleryl-CoA dehydrogenase (IVD) is a mitochondrial matrix enzyme that catalyzes the third step in leucine catabolism. The genetic deficiency of IVD results in an accumulation of isovaleric acid, which is toxic to the central nervous system and leads to isovaleric acidemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    IVD; isovaleryl-CoA dehydrogenase; isovaleryl CoA dehydrogenase , isovaleryl Coenzyme A dehydrogenase; isovaleryl-CoA dehydrogenase, mitochondrial; ACAD2; mitochondrial; FLJ12715; FLJ34849; Isovaleryl CoA dehydrogenase; Isovaleryl CoA dehydrogenase, mitochondrial; Isovaleryl Coenzyme A dehydrogenase; IVD_HUMAN;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IVD-8642H Recombinant Human IVD protein, His-tagged Insect Cells His His30-His423
Human IVD-29876TH Recombinant Human IVD, His-tagged E.coli His
Human IVD-1943H Recombinant Human Isovaleryl Coenzyme A dehydrogenase, His-tagged E.coli His
Human IVD-29875TH Recombinant Human IVD, His-tagged E.coli His 394 amino acids
Human IVD-001HCL Recombinant Human IVD cell lysate Insect Cell N/A
Human IVD-2644H Recombinant Human IVD Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human IVD-4942H Recombinant Human IVD Protein, GST-tagged Wheat Germ GST
Human IVD-5848HF Recombinant Full Length Human IVD Protein, GST-tagged In Vitro Cell Free System GST 423 amino acids
Human IVD-5996H Recombinant Human IVD Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse Ivd-8172M Recombinant Mouse Ivd protein, His & T7-tagged E.coli His/T7 Met1~Phe235 (Accession # Q9JHI5)
Mouse Ivd-3623M Recombinant Mouse Ivd Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse IVD-876M Recombinant Mouse IVD Protein (His31-Arg424), His-tagged Insect Cell His His31-Arg424
Rat IVD-3129R Recombinant Rat IVD Protein Mammalian Cell His
Rat IVD-2785R Recombinant Rat IVD Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat IVD-2785R-B Recombinant Rat IVD Protein Pre-coupled Magnetic Beads HEK293
Zebrafish IVD-11536Z Recombinant Zebrafish IVD Mammalian Cell His
Chicken IVD-4390C Recombinant Chicken IVD Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • IVD Related Articles

IVD involved in several pathways and played different roles in them. We selected most pathways IVD participated on our site, such as Branched-chain amino acid catabolism, Metabolic pathways, Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with IVD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Branched-chain amino acid catabolismALDH9A1A.2;DBT;IVD;DLD;HIBADH;PPM1K;BCKDK;HIBADHA
Metabolic pathwaysGMDS;ALOX8;CDO1;INPP4AB;PDXP;CHSY3;GPT2L;GCDHB;GAL3ST1
MetabolismOAZ3;SULT1B1;FAAH2;CDS1;APOA4B.1;ADSSL1;SULT1ST5;NFYBB;ETFB
Metabolism of amino acids and derivativesPPM1K;PAOX;AHCY;SLC25A10;OAZ2;CKMB;SLC6A8;LSM1;SLC25A15B
Valine, leucine and isoleucine degradationACADM;ALDH2;ACSF3;ACADS;IL4I1;AOX2P;HIBCH;ALDH9A1B;ALDH9A1A.1
leucine degradation

IVD has several biochemical functions, for example, electron carrier activity, fatty-acyl-CoA binding, flavin adenine dinucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IVD itself. We selected most functions IVD had, and list some proteins which have the same functions with IVD. You can find most of the proteins on our site.

Function Related Protein
electron carrier activityPRKRA;IDO1;GLRX5;NOX4;GLRX;GPX2;SDHD;HSD17B6;ACOX3
fatty-acyl-CoA bindingACADS;ACBD5B;ACBD5;ACAD8;GCDHB;ACOXL;DBIL5;ACADL;HMGCL
flavin adenine dinucleotide bindingCRY-DASH;ACADM;DLD;GFER;DPYD;GCDHB;KDM1A;ACOXL;NOS1
isovaleryl-CoA dehydrogenase activity
oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptorACOX3;IVD;ACAD9;ACAD8;ETFA;GCDHB;GCDHA;ACADVL;GCDH

IVD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IVD here. Most of them are supplied by our site. Hope this information will be useful for your research of IVD.

ssuA; SIRT4

Vashist, SK; Schneider, EM; et al. Rapid sandwich ELISA-based in vitro diagnostic procedure for the highly-sensitive detection of human fetuin A. BIOSENSORS & BIOELECTRONICS 67:73-78(2015).
Koerner, JD; Markova, DZ; et al. Differential Gene Expression in Anterior and Posterior Annulus Fibrosus. SPINE 39:1917-1923(2014).
  • Q&As
  • Reviews

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Reviews
03/13/2019

    After a prolonged quest, I have finally discovered such a steadfast and dependable protein reagent that plays an indispensable role in my research endeavors.

    05/29/2017

      This protein reagent is truly marvelous, providing stability and reliability, while becoming an invaluable assistant in my experiments.

      07/19/2016

        The unwavering high quality of this protein substance instills confidence in the accuracy of my experimental results.

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