IVD
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Official Full Name
isovaleryl-CoA dehydrogenase
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Overview
Isovaleryl-CoA dehydrogenase (IVD) is a mitochondrial matrix enzyme that catalyzes the third step in leucine catabolism. The genetic deficiency of IVD results in an accumulation of isovaleric acid, which is toxic to the central nervous system and leads to isovaleric acidemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
IVD; isovaleryl-CoA dehydrogenase; isovaleryl CoA dehydrogenase , isovaleryl Coenzyme A dehydrogenase; isovaleryl-CoA dehydrogenase, mitochondrial; ACAD2; mitochondrial; FLJ12715; FLJ34849; Isovaleryl CoA dehydrogenase; Isovaleryl CoA dehydrogenase, mitochondrial; Isovaleryl Coenzyme A dehydrogenase; IVD_HUMAN;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect Cell
- Insect Cells
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- His|T7
- Myc
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- IVD Related Articles
IVD involved in several pathways and played different roles in them. We selected most pathways IVD participated on our site, such as Branched-chain amino acid catabolism, Metabolic pathways, Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with IVD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Branched-chain amino acid catabolism | ALDH9A1A.2;DBT;IVD;DLD;HIBADH;PPM1K;BCKDK;HIBADHA |
Metabolic pathways | GMDS;ALOX8;CDO1;INPP4AB;PDXP;CHSY3;GPT2L;GCDHB;GAL3ST1 |
Metabolism | OAZ3;SULT1B1;FAAH2;CDS1;APOA4B.1;ADSSL1;SULT1ST5;NFYBB;ETFB |
Metabolism of amino acids and derivatives | PPM1K;PAOX;AHCY;SLC25A10;OAZ2;CKMB;SLC6A8;LSM1;SLC25A15B |
Valine, leucine and isoleucine degradation | ACADM;ALDH2;ACSF3;ACADS;IL4I1;AOX2P;HIBCH;ALDH9A1B;ALDH9A1A.1 |
leucine degradation |
IVD has several biochemical functions, for example, electron carrier activity, fatty-acyl-CoA binding, flavin adenine dinucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IVD itself. We selected most functions IVD had, and list some proteins which have the same functions with IVD. You can find most of the proteins on our site.
Function | Related Protein |
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electron carrier activity | PRKRA;IDO1;GLRX5;NOX4;GLRX;GPX2;SDHD;HSD17B6;ACOX3 |
fatty-acyl-CoA binding | ACADS;ACBD5B;ACBD5;ACAD8;GCDHB;ACOXL;DBIL5;ACADL;HMGCL |
flavin adenine dinucleotide binding | CRY-DASH;ACADM;DLD;GFER;DPYD;GCDHB;KDM1A;ACOXL;NOS1 |
isovaleryl-CoA dehydrogenase activity | |
oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor | ACOX3;IVD;ACAD9;ACAD8;ETFA;GCDHB;GCDHA;ACADVL;GCDH |
IVD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IVD here. Most of them are supplied by our site. Hope this information will be useful for your research of IVD.
ssuA; SIRT4
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