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Icosl

  • Official Full Name

    icos ligand

  • Overview

    ICOS ligand is a protein that in humans is encoded by the ICOSLG gene. ICOSLG has also been designated as CD275.
  • Synonyms

    ICOSL; icos ligand; B7 H2; B7 homolog 2; B7 like protein Gl50; B7 related protein 1; B7-H2; B7-like protein Gl50; B7-related protein 1; B7H2; B7RP 1; B7RP-1; B7RP1; CD 275; CD275; CD275 antigen; GL 50; GL50; ICOS LG; ICOSL_HUMAN; ICOSLG; Inducible T cell co stimulator ligand; KIAA0653; LICOS; Transmembrane protein B7 H2 ICOS ligand; B7h; GI50; GL50-B; ICOS-L; Ly115l; AU044799; BG071784; mKIAA0653;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Mouse
  • CHO
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • Mammalian Cell
  • Mammalian cells
  • C
  • His
  • hFc
  • Fc
  • His|T7
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Mouse Icosl-357M Active Recombinant Mouse Icosl, Fc-tagged, mutant CHO Fc
Mouse Icosl-356M Active Recombinant Mouse Icosl, Fc-tagged, mutant CHO Fc
Mouse Icosl-7690M Recombinant Mouse Icosl protein, His & T7-tagged E.coli His/T7 Val58~Leu249 (Accession # Q9JHJ8)
Mouse Icosl-594M Active Recombinant Mouse Icosl protein(Met1-Lys279), His&hFc-tagged HEK293 C-His&hFc Met1-Lys279
Mouse Icosl-595M Recombinant Mouse Icosl protein, His-tagged HEK293 His Glu47-Lys279
Mouse Icosl-2166M Recombinant Murine Icos Ligand, Fc Chimera Mammalian Cell Fc
Mouse ICOSLG-2804MCL Recombinant Mouse ICOSLG cell lysate Human Cell N/A
Mouse ICOSLG-2618MCL Recombinant Mouse ICOSLG cell lysate Human Cell N/A
Mouse Icosl-5442M Recombinant Mouse Icosl Protein (Glu47-Lys279), C-His tagged Mammalian cells C-His Glu47-Lys279
Mouse Icosl-594MAF488 Recombinant Mouse Icosl Protein, Fc/His-tagged, Alexa Fluor 488 conjugated HEK293 Fc/His 481
Mouse Icosl-595MAF488 Recombinant Mouse Icosl Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His Glu47-Lys279
Mouse Icosl-3470M Recombinant Mouse Icosl Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Icosl-594MAF555 Recombinant Mouse Icosl Protein, Fc/His-tagged, Alexa Fluor 555 conjugated HEK293 Fc/His 481
Mouse Icosl-595MAF555 Recombinant Mouse Icosl Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His Glu47-Lys279
Mouse Icosl-595MAF647 Recombinant Mouse Icosl Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His Glu47-Lys279
Mouse Icosl-594MAF647 Recombinant Mouse Icosl Protein, Fc/His-tagged, Alexa Fluor 647 conjugated HEK293 Fc/His 481
Mouse Icosl-595MF Recombinant Mouse Icosl Protein, His-tagged, FITC conjugated HEK293 His Glu47-Lys279
Mouse Icosl-594MF Recombinant Mouse Icosl Protein, Fc/His-tagged, FITC conjugated HEK293 Fc/His 481
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Icosl Related Articles
  • Icosl Related Research Area

Icosl involved in several pathways and played different roles in them. We selected most pathways Icosl participated on our site, such as Cell adhesion molecules (CAMs), Intestinal i, ne network for IgA production, which may be useful for your reference. Also, other proteins which involved in the same pathway with Icosl were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell adhesion molecules (CAMs)ITGB8;GLG1;MADCAM1;PVR;ICOSLG;CD4;PVRL1;CLDN22;JAM3B
Intestinal iBLA;MHC2DCB;BLB2;MHC2DEB;HLA-DMA;HLA-DQB1;CXCR4A;CCL28;HLA-DPA1
ne network for IgA productionCCL27B;CXCR4A;HLA-DRB1;ICOSLG;AICDA;MAP3K14;ICOS;HLA-DQA1;HLA-DMB

Icosl has several biochemical functions, for example, protein binding, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Icosl itself. We selected most functions Icosl had, and list some proteins which have the same functions with Icosl. You can find most of the proteins on our site.

Function Related Protein
protein bindingDDX55;CTNNAL1;C12orf68;IFNA2;NDUFAF4;C11orf46;CRABP2;MAP4K2;EPRS
receptor bindingNCK1;LAMA4;MBL2;NRG4;ANG;GNPAT;SERPINE2;NRG2B;FGF12B

Icosl has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Icosl here. Most of them are supplied by our site. Hope this information will be useful for your research of Icosl.

Nazzal, D; Gradolatto, A; et al. Human thymus medullary epithelial cells promote regulatory T-cell generation by stimulating interleukin-2 production via ICOS ligand. CELL DEATH & DISEASE 5:-(2014).
Marczynska, J; Ozga, A; et al. The Role of Metalloproteinase ADAM17 in Regulating ICOS Ligand-Mediated Humoral Immune Responses. JOURNAL OF IMMUNOLOGY 193:2753-2763(2014).
  • Q&As
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