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ID1

  • Official Full Name

    inhibitor of DNA binding 1, dominant negative helix-loop-helix protein

  • Overview

    The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the;basic HLH family of transcription factors. The encoded protein has no DNA binding activity and therefore can inhibit;the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may;play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have;been found for this gene.
  • Synonyms

    ID1; inhibitor of DNA binding 1, dominant negative helix-loop-helix protein; DNA-binding protein inhibitor ID-1; bHLHb24; dJ857M17.1.2; DNA binding protein inhibitor ID 1; DNA binding protein inhibitor ID1; Dominant negative helix loop helix protein; ID 1; ID; Inhibitor of Differentiation 1; Inhibitor of DNA binding 1; OTTHUMP00000030534; OTTHUMP00000030535; class B basic helix-loop-helix protein 24; dJ857M17.1.2 (inhibitor of DNA binding 1, dominant negative helix-loop-helix protein);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Arg
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • SUMO
  • Myc
  • DDK
  • MYC
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ID1-14041H Recombinant Human ID1, GST-tagged E.coli GST 1-155a.a.
Human ID1-531H Recombinant Human inhibitor of DNA binding 1, dominant negative helix-loop-helix protein, His-tagged E.coli His
Human ID1-146H Recombinant Human ID1 protein, Arginine-tagged E.coli Arg
Human ID1-5312HCL Recombinant Human ID1 293 Cell Lysate HEK293 N/A
Human ID1-3062H Recombinant Human ID1 protein, His-SUMO-tagged E.coli His-SUMO 1-155aa
Human ID1-3219H Recombinant Human ID1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ID1-532HFL Recombinant Full Length Human ID1 Protein, C-Flag-tagged Mammalian cells Flag
Human ID1-1131H Recombinant Human ID1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ID1-1131H-B Recombinant Human ID1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Id1-1207M Recombinant Mouse Id1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rhesus Macaque ID1-2188R Recombinant Rhesus monkey ID1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque ID1-2009R-B Recombinant Rhesus Macaque ID1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque ID1-2009R Recombinant Rhesus Macaque ID1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish ID1-8842Z Recombinant Zebrafish ID1 Mammalian Cell His
Chicken ID1-6159C Recombinant Chicken ID1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ID1 Related Articles
  • ID1 Related Research Area

ID1 involved in several pathways and played different roles in them. We selected most pathways ID1 participated on our site, such as Rap signaling pathway, TGF-beta signaling pathway, Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ID1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Rap signaling pathwayFGF11;PIK3CB;LPAR5;PLCB2;RASSF5;CALML5;PRKD2;AKT1;NGFR
TGF-beta signaling pathwayNDR1;TGFB1A;CUL1;SKP1;PITX2;IFNG;SMAD5;ACVR1B;BMPR2
Hippo signaling pathwayWTIP;BBC3;NKD1;WNT11;PARD6B;FBXW11;GDF5;WNT8B;APC
Signaling pathways regulating pluripotency of stem cellsPIK3R1;PIK3CG;MAPK1;HESX1;BMPR2;ID1;POU5F1;FZD7;FGFR3

ID1 has several biochemical functions, for example, proteasome binding, protein C-terminus binding, protein N-terminus binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ID1 itself. We selected most functions ID1 had, and list some proteins which have the same functions with ID1. You can find most of the proteins on our site.

Function Related Protein
proteasome bindingPSMG1;ADRM1;USP14;ID1;UCHL5;BAG6;UBD;DNAJB2;PSMF1
protein C-terminus bindingCALCOCO1;ATP2A2;CEP120;ERCC4;ABL1;ARL6IP5;FIGN;PICK1;FBLN1
protein N-terminus bindingSCFD1;PDLIM5;SMARCA4;ERCC5;SLC6A3;RBPJ;NPAT;ID1;ARF6
protein bindingNPL;NAE1;C9orf9;EEF1B2;SGCG;SEC13;PMM1;GPRIN2;SLC48A1
protein homodimerization activitySMAD1;GRIK1;MAP3K11;NRF1;SFTPC;MLL1;HNF1B;CLIC6;SRGAP2A
transcription factor bindingHDAC7;CHCHD2;PDCD11;SRF;KEAP1B;JUNBB;RBL1;HDAC9;TFAP2A

ID1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ID1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ID1.

CAV1; CASK; APPL1; PSMD4; SUV39H1; TCF4; TCF3; COPB1; COL12A1; TCF3; PIAS1

Bordbar, B; Ndam, NT; et al. Genetic diversity of VAR2CSA ID1-DBL2Xb in worldwide Plasmodium falciparum populations: Impact on vaccine design for placental malaria. INFECTION GENETICS AND EVOLUTION 25:81-92(2014).
Gnidehou, S; Doritchamou, J; et al. Functional Antibodies against VAR2CSA in Nonpregnant Populations from Colombia Exposed to Plasmodium falciparum and Plasmodium vivax. INFECTION AND IMMUNITY 82:2565-2573(2014).
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