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  • Official Full Name
  • insulin-degrading enzyme
  • Background
  • This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this proteins function are associated with Alzheimers disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.[provided by RefSeq, Sep 2009]
  • Synonyms
  • IDE; insulin-degrading enzyme; INSULYSIN; insulinase; insulin protease; Abeta-degrading protease;
Cat.#:IDE-255HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Insulin-degrading Enzyme, His-tagged
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Cat.#:IDE-117HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human IDE, His-tagged
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Cat.#:IDE-267HTag:His
Source (Host):Sf 21 Insect cellsSpecies:Human
Product nameRecombinant Human IDE, His-tagged
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Cat.#:IDE-2984RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat IDE Protein
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Cat.#:IDE-2190RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey IDE Protein, His-tagged
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Cat.#:IDE-5614ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish IDE
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Cat.#:Ide-761RTag:His
Source (Host):S. frugiperdaSpecies:Rat
Product nameRecombinant Rat Insulin Degrading Enzyme, His-tagged
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Cat.#:IDE-5308HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human IDE 293 Cell Lysate
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Involved Pathway

Ide involved in several pathways and played different roles in them. We selected most pathways Ide participated on our site, such as Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ide were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Alzheimers disease
NDUFA12; ITPR2; BAD; IL1B2; CAPN1; PLCB3; NOS1; Atp5g2; NDUFB4; UQCRQ

Protein Function

Ide has several biochemical functions, for example, ATP binding, ATPase activity, beta-amyloid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Ide itself. We selected most functions Ide had, and list some proteins which have the same functions with Ide. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein BUB1B; ITPKA; GRK4; AACS; DDX43; CKMA; MAPK9; PAK1; NTRK1; MAP3K9
Function ATPase activity
Related Protein ABCB1A; Abca2; MYH7; ABCD1; CLPB; DYNC1H1; DYNC2H1; KIF4; KIF4A; KIF3C
Function beta-amyloid binding
Related Protein TSSK1B; APOEB; CST3; TM2D1; APOA1; CLSTN1; ITM2C; GPRASP2; BACE1; BCHE
Function beta-endorphin binding
Related Protein IDE
Function glycoprotein binding
Related Protein Shh; FBXO17; LRRK2; APOH; Itgam&Itgb2; BBC3; SERPINA1; PTBP3; SDC1; EDEM2
Function insulin binding
Related Protein IGF1R; INSR; IDE; C2CD2L; HSPD1; PIK3R1
Function metalloendopeptidase activity
Related Protein MMP9; MMP20; ADAM10A; ADAMTS8; MMP24; ADAM19; MMP19; NRD1B; ADAMTSL5; ADAM12
Function peptide binding
Related Protein QRFPR; GNRHR4; CLTB; ADNP; OXTRL; AVPR2; THOP1; RNPEP; FNTB; AVPR1B
Function protein binding
Related Protein EMP1; PIAS4; C2orf50; HOXC4; CYTIP; WAC; ALDOB; GIT2; PDE6D; SH3YL1
Function protein homodimerization activity
Related Protein CRYAB; ERCC5; KLRB1B; KCNE2; SYT6; MCL1B; RASGRP1; VEGFA; PDK2; IRF3
Function receptor binding
Related Protein RAB8B; WNT7AA; PIPOX; DDX54; NPY; SSFA2; ANGPTL1; PGR; AMACR; TNFSF12
Function ubiquitin binding
Related Protein VPS36; SMAD3; KIF18A; DNAJC2; D17WSU92E; VPS28; OTUB1A; USP25; AUP1; SIRT2
Function virus receptor activity
Related Protein MOG; ITGB6; HTR2A; LAMP1; TFRC; CR2; ITGB3; PVRL1; CD80; AXL
Function zinc ion binding
Related Protein CA6; ZCCHC4; DZIP3; MT3; ANPEPB; NR1D2A; NR5A1; ARIH1L; TRIM61; HE1A

Interacting Protein

Ide has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ide here. Most of them are supplied by our site. Hope this information will be useful for your research of Ide.
CCL3; SIRT4; CCL4; Cdk1; NES; IFIH1

Ide Related Articles

Salpini, R; Colagrossi, L; et al. Hepatitis B Surface Antigen Genetic Elements Critical for Immune Escape Correlate With Hepatitis B Virus Reactivation Upon Immunosuppression. HEPATOLOGY 61:823-833(2015).
Romano, L; Paladini, S; et al. Hepatitis B vaccination Are escape mutant viruses a matter of concern?. HUMAN VACCINES & IMMUNOTHERAPEUTICS 11:53-57(2015).