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IDS

  • Official Full Name

    iduronate 2-sulfatase

  • Overview

    Iduronate-2-sulfatase is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this X-chromosome gene that result in enzymatic deficiency lead to the sex-linked Mucopolysaccharidosis Type II, also known as Hunter Syndrome. Iduronate-2-sulfatase has a strong sequence similarity with human arylsulfatases A, B, and C, and human glucosamine-6-sulfatase. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described.
  • Synonyms

    IDS; iduronate 2-sulfatase; SIDS; Hunter syndrome; AW214631; Alpha L iduronate sulfate sulfatase; Alpha-L-iduronate sulfate sulfatase; IDS_HUMAN; Iduronate 2 sulfatase 14 kDa chain; Iduronate 2 sulfatase 42 kDa chain; Iduronate 2 sulfatase; Iduronate 2-sulfatase 14 kDa chain; Iduronate sulfatase; Idursulfase; MPS2; RP23-29M4.1; iduronate 2-sulfatase 42 kDa chain;

  • Recombinant Proteins
  • Therapeutic Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • Mammalian Cell
  • Mammalian cells
  • C
  • Myc
  • DDK
  • His
  • His (Fc)
  • Avi
  • His|GST
  • MYC
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IDS-211H Active Recombinant Human IDS Protein, His-tagged HEK293 His
Human IDS-P037H Recombinant Human IDS therapeutic protein HEK293 N/A
Human IDS-2934HCL Recombinant Human IDS cell lysate Human Cell N/A
Human IDS-1580H Recombinant Human IDS protein, His-tagged E.coli His Arg95~Pro289 (Accession # P22304)
Human IDS-993H Recombinant Human IDS Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human IDS-2366H Recombinant Human IDS Protein (Arg95-Pro289), His tagged E.coli His Arg95-Pro289
Human IDS-017H Active Recombinant Human IDS Protein, His-tagged HEK293 His 26-550
Human IDS-093H Recombinant Human IDS Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Mouse Ids-1974M Active Recombinant Mouse Iduronate 2-Sulfatase, His-tagged Mammalian cells His
Mouse Ids-640M Active Recombinant Mouse Ids Protein, His-tagged Mammalian cells His Thr36-Pro552 (Asp177-Lys179 deletion)
Mouse IDS-7994M Recombinant Mouse IDS Protein Mammalian Cell His
Mouse Ids-4415M-B Recombinant Mouse Ids Protein Pre-coupled Magnetic Beads HEK293
Mouse Ids-1581M Recombinant Mouse Ids protein, His-tagged E.coli His Leu180~Asp448 (Accession # Q08890)
Mouse Ids-1214M Recombinant Mouse Ids Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Ids-4415M Recombinant Mouse Ids Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Ids-1582R Recombinant Rat Ids protein, His & GST-tagged E.coli His/GST Ile107~Thr363 (Accession # F1LLW8)
Zebrafish IDS-5003Z Recombinant Zebrafish IDS Mammalian Cell His
Chicken IDS-5038C Recombinant Chicken IDS Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • IDS Related Articles
  • IDS Related Research Area

IDS involved in several pathways and played different roles in them. We selected most pathways IDS participated on our site, such as Glycosaminoglycan degradation, Metabolic pathways, Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with IDS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Glycosaminoglycan degradationHPSE2;IDS;HEXB;HYAL4;ARSB;GUSB;HGSNAT;GNS;NAGLU
Metabolic pathwaysPLA2G4F;COX6B2;UGP2;GFPT1;HMGCS1;PPAP2CB;PHOSPHO2;PLA2G2E;EARS2
LysosomeENTPD4;CLTCB;Ctsl;LAMP2;CTSLA;SORT1;CTSSB.2;ATP6V0A1B;LAMP1

IDS has several biochemical functions, for example, iduronate-2-sulfatase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IDS itself. We selected most functions IDS had, and list some proteins which have the same functions with IDS. You can find most of the proteins on our site.

Function Related Protein
iduronate-2-sulfatase activity
metal ion bindingITGAX;ZNF174;ZFP526;FHL1B;MOB3A;DMRT1;EGR4;CYP2K19;ATP2A2B

IDS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IDS here. Most of them are supplied by our site. Hope this information will be useful for your research of IDS.

Dlg4; FOS; midostaurin

Andersson, B; Swolin-Eide, D; et al. Short-term changes in bone formation markers following growth hormone (GH) treatment in short prepubertal children with a broad range of GH secretion. CLINICAL ENDOCRINOLOGY 82:91-99(2015).
Boado, RJ; Hui, EKW; et al. Insulin Receptor Antibody-Iduronate 2-Sulfatase Fusion Protein: Pharmacokinetics, Anti-Drug Antibody, and Safety Pharmacology in Rhesus Monkeys. BIOTECHNOLOGY AND BIOENGINEERING 111:2317-2325(2014).
  • Q&As
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