ifnl3
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  • Official Full Name
  • interferon lambda 3
  • Background
  • IL-28B;IFN lambda-3;interferon lambda 3;Ifnl3;interleukin 28B;IL28B;IL28C;IL-28B;IFNL3;interferon, lambda 3;IL-28C;IFN-lambda-3;IFN-lambda-4;interleukin 28C;interleukin-28B;interleukin-28C;cytokine Zcyto22;interferon lambda-4;interferon, lambda 4
  • Synonyms
  • IL-28 belongs to the IFN lambda family, a novel family of cytokines within the IL-10 superfamily. The three members of this family are IL-29 (IFN lambda 1), IL-28A (IFN lambda 2), and IL-28B (IFN lambda 3), and are also known as the type III Interferons. An active IL-29 gene is absent in mice, and sequence homology between mouse IL-28A and B is 97%. Expression of these cytokines has been observed in a wide variety of cells in response to viral infection and in response to TLR3 or TLR9 ligands. The IFN lambda family signals through a heterodimeric receptor of which one subunit, IL-10R2, is shared with other members of the superfamily. The second subunit, IFN lambda R1 or IL-28R alpha, is unique to the IFN lambdas. Signaling occurs through the Jak/STAT pathway in a similar manner to signaling by the type I IFNs (IFN alpha/beta) and activates many of the same genes despite low sequence homology between the cytokines and receptors in the two families. Both IFN families display antiviral, antitumor, and antiproliferative effects, making the IFN lambdas potential alternatives to IFN-alpha for anticancer and antiviral therapies. Unlike the type I IFNs, which are able to stimulate most cells, response to IFN lambda stimulation appears to be limited to dendritic, epithelial, and some tumor cells. Another notable difference is the ability of the IFN lambda stimulation to drive dendritic cells towards the production of CD4+CD25+FoxP3+ regulatory T-cells, suggesting a possible immunoregulatory role.
Cat.#:Ifnl3-4408MTag:
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse Ifnl3 Protein
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Cat.#:IFNL3-112HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human IFNL3, His-tagged
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Cat.#:IFNL3-405HTag:His
Source (Host):CHO cellsSpecies:Human
Product nameRecombinant Human IFNL3, His-tagged
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Cat.#:IFNL3-437HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human IFNL3 Protein, His-tagged
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Cat.#:IFNL3-60HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human IFNL3, His-tagged
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Cat.#:Ifnl3-1008MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Ifnl3 Protein, His-tagged
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Cat.#:Ifnl3-860MTag:Met
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ifnl3
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Cat.#:IFNL3-3848CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken IFNL3
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Cat.#:IFNL3-12HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human IFNL3, His-tagged
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Cat.#:Ifnl3-19MTag:His/MBP
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ifnl3, His and MBP-tagged
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Cat.#:IFNL3-2059HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human IFNL3 cell lysate
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Involved Pathway

IFNL3 involved in several pathways and played different roles in them. We selected most pathways IFNL3 participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IFNL3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
CSF2RB; CCL2; TNFRSF13C; LTA; GM13305; VEGFA; IL2RB; IFNW1; CCL20A.3; IFNG1-2
Jak-STAT signaling pathway
SOCS3; MTOR; PIK3R3A; STAT3; GRB2A; IL22RA2; STAT6; IFNPHI3; GRB2B; CSF3R

Protein Function

IFNL3 has several biochemical functions, for example, cytokine activity, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IFNL3 itself. We selected most functions IFNL3 had, and list some proteins which have the same functions with IFNL3. You can find most of the proteins on our site.
Function
Related Protein
Function cytokine activity
Related Protein CCL38A.5; IFNPHI4; GM13285; IFNG1-1; Ifna15; BMP7B; Cxcl15; IFNA16; IL29; CMTM1
Function receptor binding
Related Protein ZAP70; LRRC4B; DAO1; APOL2; CX3CL1; DPP4; CCL13; TGFB2; PANX1; PKD2