Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

IGFBP7

  • Official Full Name

    insulin-like growth factor binding protein 7

  • Overview

    This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307). [provided by RefSeq, Dec 2011]
  • Synonyms

    IGFBP7; insulin-like growth factor binding protein 7; AGM; PSF; TAF; FSTL2; IBP-7; MAC25; IGFBP-7; RAMSVPS; IGFBP-7v; IGFBPRP1; insulin-like growth factor-binding protein 7; IGFBP-rP1; angiomodulin; IGF-binding protein 7; PGI2-stimulating factor; tumor-derived adhesion factor; prostacyclin-stimulating factor;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Human
  • Human Cell
  • Mammalian Cell
  • Mammalian cells
  • Spodoptera Frugiperda
  • C
  • hFc
  • Fc
  • Avi
  • His
  • His (Fc)
  • His|T7
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • GST
  • SUMO
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IGFBP7-6957H Active Recombinant Human IGFBP7 protein, His-tagged HEK293 His Asp30-Leu282
Human IGFBP7-529H Recombinant Human IGFBP7 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human IGFBP7-1630H Recombinant Human IGFBP7, His-tagged Mammalian cells His
Human IGFBP7-55H Recombinant Human IGFBP7 E.coli N/A
Human IGFBP7-2483H Recombinant human IGFBP7, His-tagged E.coli His
Human IGFBP7-5165H Active Recombinant Human IGFBP7 protein(Met1-Leu282), hFc-tagged HEK293 C-hFc Met1-Leu282
Human IGFBP7-208H Recombinant Human IGFBP7 protein E.coli N/A 256
Human IGFBP7-5054H Recombinant Human Insulin-Like Growth Factor Binding Protein 7 Human N/A
Human IGFBP7-1694HCL Recombinant Human IGFBP7 cell lysate Human Cell N/A
Human IGFBP7-3141H Recombinant Human IGFBP7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human IGFBP7-6050H Recombinant Human IGFBP7 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human IGFBP7-2949H Recombinant Human IGFBP7 Protein (Gly130-Ala280), N-His tagged E.coli N-His Gly130-Ala280
Human IGFBP7-1656H Recombinant Human IGFBP7 Protein, His&GST-tagged E.coli N-His&GST Asp30-Leu282
Human IGFBP7-2280H Recombinant Human IGFBP7 Protein, His-tagged E.coli N-His Ser24-Leu50+Gly130-Leu282
Human IGFBP7-303H Recombinant Human IGFBP7 Protein, His-tagged HEK293 His 282
Human IGFBP7-2281H Recombinant Human IGFBP7 Protein, His-tagged E.coli N-His Ser27-Leu282
Human IGFBP7-3141H-B Recombinant Human IGFBP7 Protein Pre-coupled Magnetic Beads HEK293
Human IGFBP7-1604H Active Recombinant Human IGFBP7 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Asp30-Leu282
Human IGFBP7-160H Recombinant Human IGFBP7 Protein (Ser27-Leu282), N-His-SUMO tagged, Animal-free, Carrier-free HEK293 N-His-SUMO Ser27-Leu282
Human IGFBP7-1605H Active Recombinant Human IGFBP7 protein, Fc-Avi-tagged, Biotinylated HEK293 Fc-Avi Asp30-Leu282
Human IGFBP7-1606H Active Recombinant Human IGFBP7 protein, Fc-tagged HEK293 Fc Asp30-Leu282
Mouse Igfbp7-5645M Active Recombinant Mouse Insulin-Like Growth Factor Binding Protein 7, His-tagged Spodoptera Frugiperda His
Mouse Igfbp7-1786M Recombinant Mouse Igfbp7 protein, His & T7-tagged E.coli His/T7 Lys88~Leu281 (Accession # Q61581)
Mouse Igfbp7-971M Recombinant Mouse Igfbp7 Protein, Fc-tagged HEK293 Fc
Mouse Igfbp7-3490M Recombinant Mouse Igfbp7 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat Igfbp7-1787R Recombinant Rat Igfbp7 protein, His-tagged E.coli His Lys88~Leu281
Zebrafish IGFBP7-12177Z Recombinant Zebrafish IGFBP7 Mammalian Cell His
Zebrafish igfbp7-5456Z Recombinant Zebrafish igfbp7 Protein (Gln16-Leu257), N-His tagged E.coli N-His Gln16-Leu257
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • IGFBP7 Related Articles
  • IGFBP7 Related Research Area

IGFBP7 involved in several pathways and played different roles in them. We selected most pathways IGFBP7 participated on our site, such as Cellular Senescence, Cellular responses to stress, Senescence and Autophagy, which may be useful for your reference. Also, other proteins which involved in the same pathway with IGFBP7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cellular SenescenceCDKN2D;RBB4L;PHC3;PHC2;HMGA1;H3F3D;TERF2;LMNB1;HIRA
Cellular responses to stressAMBRA1;HMGA1-RS1;DYNLL2;RBBP4;KIAA1967;LC3;ATG101;CBX6;HIST1H1E
Senescence and AutophagyUVRAG;GABARAP;GABARAPL2;SLC39A3;CREG1;IGFBP7;ATG7;MAP1LC3B;AMBRA1
Senescence-Associated Secretory Phenotype (SASP)

IGFBP7 has several biochemical functions, for example, insulin-like growth factor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IGFBP7 itself. We selected most functions IGFBP7 had, and list some proteins which have the same functions with IGFBP7. You can find most of the proteins on our site.

Function Related Protein
insulin-like growth factor bindingWISP3;WISP2;CYR61;WISP1B;IGFBP5A;CYR61L1;CTGFA;HTRA3;NOV
protein bindingZCCHC11;KIF22;TRP63;HDAC5;TWSG1;FAM134C;S100A2;KCNH1;FAM131B

IGFBP7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IGFBP7 here. Most of them are supplied by our site. Hope this information will be useful for your research of IGFBP7.

ST14; asnB; q81l39_bacan; dacA; glnK; clcA; hldE; RBBP8; q9r8c5_yerpe

Rao, C; Lin, SL; et al. High Expression of IGFBP7 in Fibroblasts Induced by Colorectal Cancer Cells Is Co-Regulated by TGF-beta and Wnt Signaling in a Smad2/3-Dvl2/3-Dependent Manner. PLOS ONE 9:-(2014).
Chugh, S; Ouzounian, M; et al. Pilot study identifying myosin heavy chain 7, desmin, insulin-like growth factor 7, and annexin A2 as circulating biomarkers of human heart failure. PROTEOMICS 13:2324-2334(2013).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
In what types of cancer is IGFBP7 research particularly focused? 07/30/2021

Research on IGFBP7 is often concentrated in breast, lung, prostate, and colorectal cancers, among others.

How does IGFBP7 contribute to cardiovascular health? 12/29/2020

IGFBP7 has been associated with cardiovascular health, and its potential role in protecting against cardiovascular diseases is an area of ongoing research.

Can IGFBP7 be used in therapeutic interventions? 12/04/2020

The potential therapeutic applications of IGFBP7 are being explored, including its use in targeted cancer therapies and other medical interventions.

Can IGFBP7 serve as a biomarker for cancer detection? 09/20/2018

Some studies suggest that IGFBP7 levels in blood or tissues may have potential as a biomarker for cancer detection.

How does IGFBP7 affect cell cycle regulation? 05/11/2018

IGFBP7 has been shown to influence the cell cycle by promoting cell cycle arrest, which can be crucial in preventing uncontrolled cell growth.

Customer Reviews (3)

Write a review
Reviews
04/09/2017

    Its purity and stability ensure consistent and accurate results, making it an ideal tool for my research endeavors.

    11/02/2016

      The manufacturer's commitment to maintaining stringent quality control measures guarantees that I can trust the protein's integrity and reliability throughout my experiments.

      09/19/2016

        This partnership enhances research productivity while ensuring accurate and meaningful outcomes.

        Ask a Question for All IGFBP7 Products

        Required fields are marked with *

        My Review for All IGFBP7 Products

        Required fields are marked with *

        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends