IGFBP7
-
Official Full Name
insulin-like growth factor binding protein 7
-
Overview
This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307). [provided by RefSeq, Dec 2011] -
Synonyms
IGFBP7; insulin-like growth factor binding protein 7; AGM; PSF; TAF; FSTL2; IBP-7; MAC25; IGFBP-7; RAMSVPS; IGFBP-7v; IGFBPRP1; insulin-like growth factor-binding protein 7; IGFBP-rP1; angiomodulin; IGF-binding protein 7; PGI2-stimulating factor; tumor-derived adhesion factor; prostacyclin-stimulating factor;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Human
- Human Cell
- Mammalian Cell
- Mammalian cells
- Spodoptera Frugiperda
- C
- hFc
- Fc
- Avi
- His
- His (Fc)
- His|T7
- Myc
- DDK
- Myc|DDK
- N/A
- N
- GST
- SUMO
- Involved Pathway
- Protein Function
- Interacting Protein
- IGFBP7 Related Articles
- IGFBP7 Related Research Area
IGFBP7 involved in several pathways and played different roles in them. We selected most pathways IGFBP7 participated on our site, such as Cellular Senescence, Cellular responses to stress, Senescence and Autophagy, which may be useful for your reference. Also, other proteins which involved in the same pathway with IGFBP7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Cellular Senescence | CDKN2D;RBB4L;PHC3;PHC2;HMGA1;H3F3D;TERF2;LMNB1;HIRA |
Cellular responses to stress | AMBRA1;HMGA1-RS1;DYNLL2;RBBP4;KIAA1967;LC3;ATG101;CBX6;HIST1H1E |
Senescence and Autophagy | UVRAG;GABARAP;GABARAPL2;SLC39A3;CREG1;IGFBP7;ATG7;MAP1LC3B;AMBRA1 |
Senescence-Associated Secretory Phenotype (SASP) |
IGFBP7 has several biochemical functions, for example, insulin-like growth factor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IGFBP7 itself. We selected most functions IGFBP7 had, and list some proteins which have the same functions with IGFBP7. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
insulin-like growth factor binding | WISP3;WISP2;CYR61;WISP1B;IGFBP5A;CYR61L1;CTGFA;HTRA3;NOV |
protein binding | ZCCHC11;KIF22;TRP63;HDAC5;TWSG1;FAM134C;S100A2;KCNH1;FAM131B |
IGFBP7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IGFBP7 here. Most of them are supplied by our site. Hope this information will be useful for your research of IGFBP7.
ST14; asnB; q81l39_bacan; dacA; glnK; clcA; hldE; RBBP8; q9r8c5_yerpe
- Q&As
- Reviews
Q&As (5)
Ask a questionResearch on IGFBP7 is often concentrated in breast, lung, prostate, and colorectal cancers, among others.
IGFBP7 has been associated with cardiovascular health, and its potential role in protecting against cardiovascular diseases is an area of ongoing research.
The potential therapeutic applications of IGFBP7 are being explored, including its use in targeted cancer therapies and other medical interventions.
Some studies suggest that IGFBP7 levels in blood or tissues may have potential as a biomarker for cancer detection.
IGFBP7 has been shown to influence the cell cycle by promoting cell cycle arrest, which can be crucial in preventing uncontrolled cell growth.
Customer Reviews (3)
Write a reviewIts purity and stability ensure consistent and accurate results, making it an ideal tool for my research endeavors.
The manufacturer's commitment to maintaining stringent quality control measures guarantees that I can trust the protein's integrity and reliability throughout my experiments.
This partnership enhances research productivity while ensuring accurate and meaningful outcomes.
Ask a Question for All IGFBP7 Products
Required fields are marked with *
My Review for All IGFBP7 Products
Required fields are marked with *