ighm
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  • Official Full Name
  • Immunoglobulin heavy constant mu
  • Background
  • Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule is made up of 2 identical heavy;chains and 2 identical light chains (see MIM 147200) joined by disulfide bonds so that each heavy chain is linked to a;light chain and the 2 heavy chains are linked together. Each Ig heavy chain has an N-terminal variable (V) region;containing the antigen-binding site and a C-terminal constant (C) region, encoded by an individual C region gene, that;determines the isotype of the antibody and provides effector or signaling functions. The heavy chain V region is;encoded by 1 each of 3 types of genes: V genes (see MIM 147070), joining (J) genes (see MIM 147010), and diversity (D);genes (see MIM 146910). The C region genes are clustered downstream of the V region genes within the heavy chain locus;on chromosome 14. The IGHM gene encodes the C region of the mu heavy chain, which defines the IgM isotype. Naive B;cells express the transmembrane forms of IgM and IgD (see IGHD; MIM 1471770) on their surface. During an antibody;response, activated B cells can switch to the expression of individual downstream heavy chain C region genes by a;process of somatic recombination known as isotype switching. In addition, secreted Ig forms that act as antibodies can;be produced by alternative RNA processing of the heavy chain C region sequences. Although the membrane forms of all Ig;isotypes are monomeric, secreted IgM forms pentamers, and occasionally hexamers, in plasma (summary by Janeway et al.,;2005).
  • Synonyms
Cat.#:IGHM-843HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human IGHM cell lysate
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Involved Pathway

Ighm involved in several pathways and played different roles in them. We selected most pathways Ighm participated on our site, such as Adaptive Immune System, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers, B Cell Receptor Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ighm were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adaptive Immune System
TREM1; MGC174155; FRS2; KIF5A; FRS2A; UBE2E3; FRS2B; CRTAM; ASB8; AGO3
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
SRMS; PIK3AP1; STIM1B; BLK; IGKV1-5; IGLC2; IGKC; IGHM; AKR1C1; AHCYL1
B Cell Receptor Signaling Pathway
PDK2B; NFATC3; STAP1; LIME1; CTNNB2; CRKL; PPP3CA; HRAS; ACTR2; NFKB1
Immune System
BST2; TNRC5; POLR3H; BTR22; SIGLEC8; KIF3C; ACTR1B; TRIM22; IgG3; RNF41
Signaling by the B Cell Receptor (BCR)
STIM1B; SRMS; PIK3AP1; IGHM

Protein Function

Ighm has several biochemical functions, for example, antigen binding, contributes_to immunoglobulin receptor binding, contributes_to peptidoglycan binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Ighm itself. We selected most functions Ighm had, and list some proteins which have the same functions with Ighm. You can find most of the proteins on our site.
Function
Related Protein
Function antigen binding
Related Protein LILRA2; KIR2DL3; TSPAN4; Ighg2b; IGHM; LILRA1; SPON2; HNRNPM; Ighg; PPP2R1A
Function contributes_to immunoglobulin receptor binding
Related Protein IGHM; IGJ
Function contributes_to peptidoglycan binding
Related Protein IGJ; IGHM
Function contributes_to phosphatidylcholine binding
Related Protein IGHM; IGJ
Function protein binding
Related Protein INHA; EZH2; FGFR1; SNRNP70; APLP1; ATP6V1G1; CD84; ZBTB22; MTMR7; NDUFA9
Function contributes_to single-stranded DNA binding
Related Protein IGHM; MLH1; MSH2; PMS2; POLR2D; IGJ; MSH3

Ighm Related Articles

Vollmers, C; Penland, L; et al. Novel Exons and Splice Variants in the Human Antibody Heavy Chain Identified by Single Cell and Single Molecule Sequencing. PLOS ONE 10:-(2015).
Enders, A; Short, A; et al. Zinc-finger protein ZFP318 is essential for expression of IgD, the alternatively spliced Igh product made by mature B lymphocytes. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111:4513-4518(2014).