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IKBKB

  • Official Full Name

    inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta

  • Overview

    NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).
  • Synonyms

    IKBKB; IKK2; IKKB; NFKBIKB; FLJ33771; FLJ36218; FLJ38368; FLJ40509; IKK-beta; MGC131801; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; inhibitor of nuclear factor kappa-B kinase subunit beta; IKK-B; I-kappa-B kinase 2; OTTHUMP00000225854; OTTHUMP00000225858; OTTHUMP00000225860; OTTHUMP00000225865; OTTHUMP00000225866; I-kappa-B-kinase beta; nuclear factor NF-kappa-B inhibitor kinase beta;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • S.frugiperda
  • Sf21
  • Sf9 Insect Cell
  • Wheat Germ
  • Yeast
  • C
  • His
  • Flag
  • GST
  • GST|His
  • His (Fc)
  • Avi
  • His|GST
  • His|T7
  • MYC
  • DDK
  • Myc|DDK
  • N/A
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IKBKB-88H Active Recombinant Human IKKB-beta Sf9 Insect Cell GST/His
Human IKBKB-79HFL Active Recombinant Full Length Human IKBKB Protein, N-His-tagged Sf21 His Full Length
Human IKBKB-87H Recombinant Human IKBKB Protein, His-tagged E. coli His 1-756aa
Human IKBKB-1027H Recombinant Human Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B-Cells, Kinase Beta, GST-tagged Sf9 Insect Cell GST
Human IKBKB-14132H Recombinant Human IKBKB, GST-tagged E.coli GST 1-256a.a.
Human IKBKB-53H Recombinant Human IKBKB protein, Flag-tagged, Biotinylated Insect Cell Flag
Human IKBKB-89H Recombinant Human IKB-beta E.coli GST
Human IKBKB-501H Recombinant Human IKBKB Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human IKBKB-125H Recombinant Human IKBKB protein, GST-tagged Insect Cell GST
Human IKBKB-760H Recombinant Human IKBKB, His-S S.frugiperda His
Human IKBKB-28877TH Recombinant Human IKBKB Wheat Germ N/A 256 amino acids
Human IKBKB-2661H Recombinant Human IKBKB, GST-His Sf9 Insect Cell GST
Human IKBKB-849HCL Recombinant Human IKBKB cell lysate N/A
Human IKBKB-1162H-B Recombinant Human IKBKB Protein Pre-coupled Magnetic Beads HEK293
Human IKBKB-3571H Recombinant Human IKBKB protein, His-tagged E.coli His 1-256 aa
Human IKBKB-1720H Recombinant Human IKBKB protein, His & GST-tagged E.coli His/GST Asp246~Val528 (Accession # O14920)
Human IKBKB-255HF Recombinant Full Length Human IKBKB Protein In Vitro Cell Free System 256 amino acids
Human IKBKB-2231H Recombinant Human IKBKB protein, His-tagged Yeast His 1-756aa
Human IKBKB-1064H Recombinant Human IKBKB Protein (S695-S756), Tag Free Insect Cell No tag S695-S756
Human IKBKB-421HFL Active Recombinant Full Length Human IKBKB Protein, C-Flag-tagged Mammalian cells Flag
Human IKBKB-1162H Recombinant Human IKBKB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human IKBKB-1065H Recombinant Human IKBKB Protein (S695-S756), GST tagged Insect Cell GST S695-S756
Mouse Ikbkb-1721M Recombinant Mouse Ikbkb protein, His & T7-tagged E.coli His/T7 Met1~Trp231 (Accession # O88351)
Mouse Ikbkb-5691M Recombinant Mouse Ikbkb Protein (Ser2-Asp757), C-His tagged E.coli C-His Ser2-Asp757
Mouse Ikbkb-1232M Recombinant Mouse Ikbkb Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rhesus Macaque IKBKB-2225R Recombinant Rhesus monkey IKBKB Protein, His-tagged Mammalian Cell His
Rhesus Macaque IKBKB-2046R Recombinant Rhesus Macaque IKBKB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque IKBKB-2046R-B Recombinant Rhesus Macaque IKBKB Protein Pre-coupled Magnetic Beads HEK293
Zebrafish IKBKB-6658Z Recombinant Zebrafish IKBKB Mammalian Cell His
Chicken IKBKB-3048C Recombinant Chicken IKBKB Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

IKBKB involved in several pathways and played different roles in them. We selected most pathways IKBKB participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IKBKB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayTNFRSF1A;RELB;TGFB3;FAS;CACNA1B;GRB2A;RAC1A;MAP4K3;PAK1
Ras signaling pathwayPLA2G6;PRKCB;STK4;RAP1A;BCL2L1;PAK1;GNG11;FGF7;CSF1
Chemokine signaling pathwayGRK4;CCR6;RAP1B;GRB2;PTK2;PIK3CB;GNG8;RHOA;PF4
NF-kappa B signaling pathwayMYD88;VCAM1;CCL21;ICAM1;NFKBIA;TICAM2;LY96;CCL19;PLCG1
FoxO signaling pathwayFasl;MAPK9;STAT3;S1PR1;MAPK10;PRKAA1;FASLG;FOXO3B;INSB
mTOR signaling pathwayVEGFAB;INS;PIK3R2;PTENA;PIK3CD;PIK3CG;PIK3R1;AKT1S1;BRAF
PIK-Akt signaling pathwayKitl;LAMB4;ITGA4;IFNAR2;IFNB1;OSM;RPS6;Fgf15;IBSP
ApoptosisPRKAR1A;CAPN1B;IRAK3;GZMC;CTNNB1;CDK5RAP2;DSP;PRKACBA;DSG1
Osteoclast differentiationFOSB;PIK3CB;MAPK13;SYK;PIK3CG;NCF1;PPP3R1;ACP5;TNFRSF1A
Toll-like receptor signaling pathwayMAPK8A;IRF5;IFNA10;AKT2L;MAPK11;IL8L1;IFNA17;NFKBIAB;MAPK8
NOD-like receptor signaling pathwayRELA;CCL5;NLRC4;MAPK14A;CARD9;HSP90B1;HSP90AA1.1;MAPK8A;NAIP1
RIG-I-like receptor signaling pathwayTRAF2;DHX58;AZI2;DDX3X;SIKE1;ISG15;IFNA17;IKBKG;IFNA1
Cytosolic DNA-sensing pathwayIFNA21;IFNA12;CXCL10;POLR2EB;IFNA1;IFNA13;POLR2F;IKBKB;RIPK1L
T cell receptor signaling pathwayMAPK11;IL5;SOS1;PIK3R2;RAF1;MAPK12;NCK2;GRAPA;RHOA
B cell receptor signaling pathwayPIK3CD;CD72;ARPC2;PLEKHA1;PIK3AP1;RAF1;VAV2;PIK3CA;PTPN18
TNF signaling pathwayCasp3;BIRC3;MAPK9;CREB5;CXCL3;PIK3R5;BCL3;MAP3K5;PIK3CG
Neurotrophin signaling pathwayPIK3R3;MAPK1;SORT1;MAP2K1;HRAS;MAP3K3;MAPK9;NTRK3;RAF1
Insulin signaling pathwayLIPE;SOCS9;AKT3A;PRKAG3B;GRB2;SHC2;PIK3R1;MKNK1;INPP5K
Adipocytokine signaling pathwayNFKBIAA;JAK2;ACACB;PRKAA2;RXRAA;PRKAG2A;MAPK8A;CHUK;G6PCA.1
Type II diabetes mellitusMTOR;PRKCZ;PDX1;PIK3R3;HK1;MAPK10;PIK3R1;HKDC1;PIK3CG
Insulin resistancePRKAG2A;G6PC3;SREBF1;PPP1CC;RPS6KB1B;GSK3B;PIK3CG;CREB5;MAPK8A
Non-alcoholic fatty liver disease (NAFLD)TRAF2;NDUFA9;NDUFC2-KCTD14;NDUFA3;NR1H3;Fasl;RELA;ITCH;PRKAB1
Epithelial cell signaling in Helicobacter pylori infectionCXCR1;NFKB1;ATP6V1C2;ATP6V0C;ADAM17;ATP6V1E1;ATP6V1H;CCL5;JAM3
ShigellosisNFKBIA;CTTN;NFKBIB;FBXW11;SRC;WAS;MAPK10;DIAPH1;MAPK9
Chagas disease (American trypanosomiasis)IL1B2;TGFBR2;MAPK3;IRAK1;GNAI2;IKBKG;SERPINE1;PIK3CD;PPP2R2A
ToxoplasmosisHLA-DMA;HSPA2;HLA-DPA1;IL12A;HSPA1B;HLA-DRB3;GNAI3;NFKBIB;HLA-DQB1
Hepatitis CTRP53;MAPK11;Ifna11;DDX58;MAPK8;PPP2R1B;CLDN5;CLDN8;HRAS
Hepatitis BSTAT4;SMAD4;EP300;MAVS;FASLG;CASP10;CYCS;OSTN;MAPK8
Influenza AIRF9;MAPK1;DNAJB1;GSK3B;IL18;DDX39B;IFNA1;PLG;IVNS1ABP
HTLV-I infectionHLA-C;DVL2;RRAS2;CANX;CRTC2;EGR2;ATM;KAT2B;TRP53INP1
Herpes simplex infectionIL1B;IFNA6;HLA-DQA2;EIF2AK3;HLA-DPA1;FB06F03;SKP2;DAXX;CRFB2
Epstein-Barr virus infectionPSMD1;XPO1;HLA-G;MAP2K6;YWHAE;PLCG1;HLA-A;MAPK13;FGR
Pathways in cancerCSF3R;GNG11;PLCB2;WNT6;PLCB1;CXCR4;ARNT2;HHIP;FIGF
MicroRNAs in cancerSERPINB5;MMP9;DNMT3A;NRAS;ABCB1A;SLC45A3;TRP63;SHC1;APC
Pancreatic cancerIKBKG;TGFA;PIK3CA;MAPK1;TRP53;BCL2L1;PIK3R2;ERBB2;RAC2
Prostate cancerFOXA1;SRD5A2;NRAS;PIK3R2;CASP9;PDGFC;MDM2;BCL2;ARID1A
Chronic myeloid leukemiaIKBKG;PIK3CA;RB1;MAPK3;BCL2L1;CCND1;SHC4;TGFBR2;AKT1
Acute myeloid leukemiaRUNX1T1;PPARD;PIK3CA;TCF7;CEBPA;MAP2K2;PIK3CG;IKBKG;RPS6KB1
Small cell lung cancerNFKB1;PTK2;NFKBIA;PIK3R5;IKBKG;PIK3CA;PIK3R1;BIRC2;PIK3R3

IKBKB has several biochemical functions, for example, ATP binding, IkappaB kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IKBKB itself. We selected most functions IKBKB had, and list some proteins which have the same functions with IKBKB. You can find most of the proteins on our site.

Function Related Protein
ATP bindingDGKD;TTBK2;TTN;SMOK2B;PNCK;STRADB;CSF1R;LACE1B;PRKDC
IkappaB kinase activityIKBKB;IKBKE;CHUK
protein bindingOAS1B;TBC1D7;RIBC2;WFDC9;XK;TAOK3;PPHLN1;UBE2Q1;DLG4
protein heterodimerization activityANO2;APITD1;CD3D;DDIT3;SMC2;HYPM;HIST1H2BD;SOX5;HIST2H2BE
protein homodimerization activityDGCR8;SNRPC;MCL1;BCL2L10;TRIM9;TSC2;HMGCS1;BARD1;APOA1BP
protein kinase activityPRKACAA;MAP4K6;NEK4;STK35L;CAMK1DB;TRIM24;AURKA;cka1;ROCK2A
protein kinase bindingTRIM6;MLKL;APC;PTK2;FOXM1;RPS6KA3;GSK3B;FGF19;ACTA2
protein serine/threonine kinase activityCDKL5;VRK2;CLK1;STK35;RAF1A;BMPR2B;NEK11;STK19;ZNF143B
scaffold protein bindingNLGN1;P2RY1;KCNH2;KRT18;LRP4;SRC;DSP;MAP2K2;GRIN2A

IKBKB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IKBKB here. Most of them are supplied by our site. Hope this information will be useful for your research of IKBKB.

IKBKG

  • Q&As
  • Reviews

Q&As (5)

Ask a question
How is IKBKB protein involved in inflammatory diseases? 02/24/2023

IKBKB protein is a key regulator of the NF-κB pathway, which plays a central role in the inflammatory response. Dysregulation of IKBKB can contribute to the development of inflammatory diseases.

Can dysregulation of IKBKB protein contribute to neurodegenerative diseases? 11/05/2020

Yes, dysregulation of IKBKB protein and the NF-κB pathway has been implicated in neuroinflammation and the pathogenesis of neurodegenerative diseases such as Alzheimer's and Parkinson's disease.

Is there any potential for targeting IKBKB protein in the treatment of autoimmune diseases? 08/21/2020

Yes, targeting IKBKB protein or the NF-κB pathway is being explored as a potential strategy for treating autoimmune diseases by modulating the inflammatory response.

How is IKBKB protein involved in the regulation of cell survival and apoptosis? 08/28/2019

IKBKB protein activates the NF-κB pathway, which can promote cell survival and inhibit apoptosis in response to various stimuli, making it a potential target for cancer therapy.

Can mutations in the IKBKB gene lead to human diseases? 12/23/2018

Yes, mutations in the IKBKB gene have been associated with immunodeficiency disorders and inflammatory diseases, highlighting the importance of IKBKB protein in immune system function.

Customer Reviews (3)

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Reviews
04/26/2020

    Their team of experts is readily available to assist you with any inquiries or challenges you may encounter during your experiments.

    09/24/2018

      Its purity and functional integrity guarantee optimal performance in a wide range of experimental applications.

      04/13/2016

        This protein, manufactured with utmost precision, provides reliable and consistent results, ensuring the accuracy and reproducibility of your research findings.

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