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INPP5F

  • Official Full Name

    inositol polyphosphate-5-phosphatase F

  • Overview

    The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase and contains a Sac domain. The activity of this protein is specific for phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
  • Synonyms

    INPP5F; inositol polyphosphate-5-phosphatase F; phosphatidylinositide phosphatase SAC2; hSac2; KIAA0966; SAC2; cI-27; Inositol polyphosphate 5 phosphatase F; MSTP007; MSTP047; Sac domain containing inositol phosphatase 2; Sac domain-containing phosphoinositide 5-phosphatase 2; Sac domain-containing inositol phosphatase 2; MSTPO47;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human INPP5F-863HCL Recombinant Human INPP5F cell lysate N/A
Human INPP5F-2398H Recombinant Human INPP5F Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human INPP5F-5409H Recombinant Human INPP5F Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse Inpp5f-184M Recombinant Mouse Inpp5f Protein, MYC/DDK-tagged HEK293T MYC/DDK
Zebrafish INPP5F-6735Z Recombinant Zebrafish INPP5F Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • INPP5F Related Articles

INPP5F involved in several pathways and played different roles in them. We selected most pathways INPP5F participated on our site, such as 3-phosphoinositide degradation, D-myo-inositol (1,4,5)-trisphosphate degradation, superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with INPP5F were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
3-phosphoinositide degradationPTPMT1;INPP5F
D-myo-inositol (1,4,5)-trisphosphate degradation
superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism

INPP5F has several biochemical functions, for example, phosphoric ester hydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by INPP5F itself. We selected most functions INPP5F had, and list some proteins which have the same functions with INPP5F. You can find most of the proteins on our site.

Function Related Protein
phosphoric ester hydrolase activitySACM1LB;SYNJ1;RAG1;RNASEKA;REXO4;TMPPE;EXO5;SACM1LA;FBP1B

INPP5F has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INPP5F here. Most of them are supplied by our site. Hope this information will be useful for your research of INPP5F.

YWHAB

Montjean, R; Aoidi, R; et al. OCRL-mutated fibroblasts from patients with Dent-2 disease exhibit INPP5B-independent phenotypic variability relatively to Lowe syndrome cells. HUMAN MOLECULAR GENETICS 24:994-1006(2015).
Kim, HS; Li, AG; et al. Inositol Polyphosphate-5-Phosphatase F (INPP5F) inhibits STAT3 activity and suppresses gliomas tumorigenicity. SCIENTIFIC REPORTS 4:-(2014).
  • Q&As
  • Reviews

Q&As (7)

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How does INPP5F affect HCC cell proliferation? 04/24/2022

Overexpression of INPP5F promotes HCC cell proliferation, while its knockdown suppresses tumor growth.

How does INPP5F influence lactate production and glucose consumption in HCC cells? 08/20/2021

INPP5F enhances lactate production and glucose consumption in HCC cells.

What is the role of INPP5F in hepatocellular carcinoma (HCC)? 03/18/2021

INPP5F plays a role in HCC and is associated with tumor growth and progression.

What is the impact of INPP5F's subcellular location in HCC? 08/25/2020

In HCC, INPP5F is commonly located in the cytoplasm, whereas it is nuclear-located in cells of adjacent non-tumor tissues.

What signaling pathway is activated by INPP5F in HCC? 04/29/2018

INPP5F activates the Notch signaling pathway in HCC.

What is the expression pattern of INPP5F in HCC tissues? 03/18/2018

INPP5F is highly expressed in HCC tissues and is associated with poor prognosis in HCC patients.

What genes and processes are regulated by INPP5F in HCC? 03/24/2016

INPP5F regulates cell cycle-related genes (c-MYC and cyclin E1) and promotes aerobic glycolysis-related genes.

Customer Reviews (3)

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Reviews
05/18/2020

    Its speed in modulating signaling pathways allowed us to obtain results quickly, saving valuable time.

    10/25/2017

      The product's biocompatibility with various cell types and organisms made it versatile for a wide range of applications.

      02/21/2017

        The product's stability over extended periods was a significant advantage for our long-term research projects.

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