ITGA4
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Official Full Name
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
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Overview
The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain. -
Synonyms
ITGA4; integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor); IA4; CD49D;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- CHO
- E.coli
- HEK293
- HEK293T
- Human Cell
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- His
- Flag
- GST
- His (Fc)
- Avi
- His|Avi
- Myc
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- ITGA4 Related Articles
- ITGA4 Related Research Area
ITGA4 involved in several pathways and played different roles in them. We selected most pathways ITGA4 participated on our site, such as PIK-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGA4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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PIK-Akt signaling pathway | COL6A6;PDGFB;NOS3;TCL1;PPP2CA;PHLPP2;GNG2;PDPK1;TNR |
Focal adhesion | MYL12.2;VCLA;PAK6;ITGA2B;LAMA3;COL1A1B;ITGB8;IGF1R;PDGFRA |
ECM-receptor interaction | COL1A1;COL1A1A;COL1A1B;COL27A1;ITGA11A;VTNA;THBS3;THBS3A;COL27A1B |
Cell adhesion molecules (CAMs) | CLDN6;CLDN7A;CLDN1;CLDN2;CLDNE;CD58;CD8A;ICAM1;SELE |
Hematopoietic cell lineage | ITGAM;CD22;CSF3;CSF1;ITGA3;TFRC;CR1;IL7R;CD1E |
Leukocyte transendothelial migration | MAPK11;RAC2;CD99;RHOH;VAV1;CTNNA3;PTK2B;THY1;TXK |
Intestinal i | CCR10;IL-15RA;BMA1;HLA-DMA;HLA-DRB3;HLA-DQA2;HLA-DRB4;CCR9A;HLA-DPA1 |
ne network for IgA production | ICOSLG;IL6;CCL27B;TNFSF13;TNFRSF13B;PIGR;HLA-DMB;MHC2A;IL15 |
Regulation of actin cytoskeleton | ACTN3A;MSN;RAC2;APC;WASF1;ACTN1;FGF1;PTK2AB;FGF1B |
Leishmaniasis | MAPK13;HLA-DOB;PRKCB;TRAF6;FCGR1A;FCGR2C;HLA-DMA;TNF;FCGR4 |
Hypertrophic cardiomyopathy (HCM) | SGCA;CACNG4;ITGA1;SGCD;ACTC1;CACNA2D2;ITGA10;ITGA9;MYL2 |
Arrhythmogenic right ventricular cardiomyopathy (ARVC) | DMD;CDH2;CACNB2;ITGA7;ACTN1;AASS;ITGB4;RYR2;GJA1 |
Dilated cardiomyopathy | ITGB4;SGCA;ITGA7;GNAS;ITGA2B;PRKACA;MYL3;ITGA3;ITGA4 |
ITGA4 has several biochemical functions, for example, cell adhesion molecule binding, fibronectin binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGA4 itself. We selected most functions ITGA4 had, and list some proteins which have the same functions with ITGA4. You can find most of the proteins on our site.
Function | Related Protein |
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cell adhesion molecule binding | CXADR;PVRL3;PVRL4;CRTAM;CADM1B;NLGN4X;MSN;GRIN2A;CD1D |
fibronectin binding | CTSK;IGFBP3;THBS1;CTSS;PLEKHA2;FBLN1;CCDC80;MYOC;VEGFA |
metal ion binding | SCRT2;ZNF222;CFI;ZFP768;REPIN1;RPE65;ARAP2;SMPD4;KSR2 |
protein antigen binding | ITGA4;KLRC2;H2-AB1;KLRD1;EP300 |
protein binding | APBA2;CNTNAP4;DUSP26;IMMT;CDH2;CDK13;PSPC1;CCP110;CALCOCO2 |
ITGA4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGA4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGA4.
PXN; ITGB1; VCAM1; LYN; TGFB1I1; LPXN; ITGB1; FLNA
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