ITLN1
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Official Full Name
Intelectin-1
- Recombinant Proteins
- Human
- Mouse
- Rat
- Zebrafish
- CHO
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- Fc
- Flag
- GST
- His
- N/A
- N
- Background
- Quality Guarantee
- Case Study
- Involved Pathway
- Protein Function
- Interacting Protein
- ITLN1 Related Research Area
What is ITLN1 protein?
ITLN1 (intelectin 1) gene is a protein coding gene which situated on the long arm of chromosome 1 at locus 1q23. Intelectin 1 (ITLN1), also known as Omentin-1, is a protein encoded by the ITLN1 gene. It was originally found in the human small intestine, but has since been widely expressed in tissues such as human adipose tissue, intestine, lung, kidney, and skin. The Intelectin 1 protein is a secreted member of the globulin family that is structurally similar to lysozyme and consists of two subunits. The ITLN1 protein is consisted of 313 amino acids and its molecular mass is approximately 35.0 kDa.
What is the function of ITLN1 protein?
It is thought to be closely related to inflammatory regulation, immune regulation, metabolic regulation and disease development. Studies have shown that ITLN1 protein plays an important regulatory role in the body's anti-inflammatory effects. It is able to regulate inflammatory responses by binding to pathogens and participate in the host's defense against microbial infections.
Fig1. (A) Omentin-1 ameliorates vascular cell dysfunction. (B) Underlying relationship among metformin/statins, omentin-1 and IS outcome. (Shiyi Lin, 2021)
ITLN1 Related Signaling Pathway
The signaling pathways involved in Intelectin 1 mainly include immune system related signaling pathways, such as Toll-like receptor (TLR) signaling pathway, NF-κB signaling pathway and inflammatory response signaling pathway. In addition, ITLN1 is also associated with apoptosis signaling pathways. In the apoptosis signaling pathway, Intelectin 1 can affect the occurrence of apoptosis by regulating the activity of Caspase family proteins.
ITLN1 Related Diseases
The ITLN1 has been linked to the development of metabolic diseases such as obesity, diabetes, cardiovascular disease and kidney disease. ITLN1 has also been found to be associated with the onset and development of tumors and inflammatory diseases.
Bioapplications of ITLN1
The ITLN1 protein is found in certain seafood products, such as cod and salmon roe, and is expected to be used in the development of functional foods and health products. Other applications are mainly in the field of medical research, particularly related to cancer.
High Purity
Fig1. SDS-PAGE (ITLN1-4958H) (PROTOCOL for western blot)
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Fig2. SDS-PAGE (ITLN1-3558H) (PROTOCOL for western blot)
Case study 1: Xin Huang, 2022
One of the main causes of low back pain (LBP) and degenerative musculoskeletal disorders is intervertebral disc degeneration (IVDD). Inflammation-associated senescence of Human nucleus pulposus cells (HNPCs) plays an essential function in the disease progression of IVDD. Omentin-1 is an adipokine that has been recently reported to have anti-inflammatory potential. So does Omentin-1 play an anti-inflammatory role in the development of IVDD disease?
The researchers investigated in vitro the effects of Omentin-1 on HNPCs, including the components of senescence, cell cycle and extracellular matrix (ECM) synthesis. The results showed that the addition of Omentin-1 improved IL-1β-induced senescence in HNPC. And the effect of Omentin-1 in reducing senescence of HNPCs is dependent on SIRT1. These findings suggest that Omentin-1 plays an important function in protecting HNPCs against senescence and has the potential for IVDD gene target therapy.
Fig1. Omentin-1 protein expression in HNPCs stimulated by different concentrations of IL-1β was assessed by Western blot analysis.
Case study 2: Chi-Lam Au-Yeung, 2020
Advanced ovarian cancer usually spreads to the omentum. However, the omental cell-derived molecular determinants modulating its progression have not been thoroughly characterized. Here, this study shows that circulating ITLN1 has prognostic significance in patients with advanced ovarian cancer.
Further studies demonstrate that ITLN1 suppresses lactotransferrin's effect on ovarian cancer cell invasion potential and proliferation by decreasing MMP1 expression and inducing a metabolic shift in metastatic ovarian cancer cells. Additionally, ovarian cancer-bearing mice treated with ITLN1 demonstrate marked decrease in tumor growth rates. These data suggest that downregulation of mesothelial cell-derived ITLN1 in the omental tumor microenvironment facilitates ovarian cancer progression.
Fig3. Western blot analyses show a lower ITLN1 protein expressions in ovarian cancer-associated mesothelial cells (n = 5) compared with normal mesothelial cells.
Fig1. Counteractive action of omentin-1 against inflammation related to atherosclerosis. (Shiyi Lin, 2021)
Fig2. Schematic representation of the effects of omentin-1 on insulin signaling cascade that explain positive effects of these adipokines on glycemic control. (Xiongfeng Pan, 2019)
ITLN1 involved in several pathways and played different roles in them. We selected most pathways ITLN1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ITLN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
ITLN1 has several biochemical functions, for example, carbohydrate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITLN1 itself. We selected most functions ITLN1 had, and list some proteins which have the same functions with ITLN1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| carbohydrate binding | MAG;CHI3L2;CLEC4E;GALNT11;LGALS8;CLEC4F;ZG16B;WBSCR17;KLRC4-KLRK1 |
ITLN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITLN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITLN1.
- Q&As
- Reviews
Q&As (6)
Ask a questionIn future studies, it is worth paying attention to the relationship between structure and function, expression regulation, association with other proteins or diseases, and therapeutic potential. At the same time, further research is needed on the similarities and differences between them and other protein inhibitors, as well as their differences in different species.
The expression level of ITLN1 is regulated by a variety of factors, including processes such as gene transcription, translation, and post-translational modifications, as well as hormones, nutrients, and other environmental factors in the body.
Yes, ITLN1 may have other biological activities in addition to trypsin inhibitory activity. For example, it may play a role in processes such as immune regulation, cell growth, and apoptosis.
Yes, there may be some differences in ITLN1 in different species, such as different degrees of variation in structure, function, and expression levels.
The synthesis and secretion of ITLN1 in the human body involves multiple steps and complex regulatory mechanisms, including gene transcription, translation, post-translational modification and secretion.
There are certain similarities and differences between ITLN1 and other protein inhibitors in terms of structure, function, and mechanism of action. For example, other protein inhibitors may have different mechanisms of inhibition and ranges of action.
Customer Reviews (3)
Write a reviewITLN1 activity is good, and the required biological activity experiments can be carried out effectively.
The results show that the protein has good crystallinity, which is helpful for crystallographic study.
Its high solubility allows for easy preparation of the required concentration.
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