AMICA1
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Official Full Name
adhesion molecule, interacts with CXADR antigen 1
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Synonyms
AMICA1; adhesion molecule, interacts with CXADR antigen 1; junctional adhesion molecule-like; mCrea7; adhesion molecule AMICA; dendritic cell-specific protein CREA7; dendritic-cell specific protein Crea7; AMICA; Crea7; Gm638; MGC61025; JAML; CREA7-1; CREA7-4;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rhesus Macaque
- HEK293
- HEK293T
- Human Cell
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- hFc
- Fc
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- AMICA1 Related Articles
AMICA1 involved in several pathways and played different roles in them. We selected most pathways AMICA1 participated on our site, such as Adaptive Immune System, Cell surface interactions at the vascular wall, Hemostasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with AMICA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adaptive Immune System | EVL;RNF6;FGFR1B;MAP3K8;LILRB4;Mill2;GAN;CTS7;FGF8B |
| Cell surface interactions at the vascular wall | CEACAM6;CEACAM1;CD177;ANGPT2A;MERTK;SIRPA;SLC16A1;DOK2;PROCR |
| Hemostasis | KIF9;KIF15;PHF21A;KIF5A;HBB-Y;LOC100514666;CEACAM8;KIF3C;CD9A |
| Immune System | Mill2;CASPBL;IRF6;MYO9B;EDAR;ASB9;IL1RN;GAN;KIF4A |
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | KLRG1;CD300A;LILRB5;TREML1;CD300LF;LAIR2;KLRB1F;CD300LD;RAET1E |
AMICA1 has several biochemical functions, for example, cell adhesion molecule binding, integrin binding, protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AMICA1 itself. We selected most functions AMICA1 had, and list some proteins which have the same functions with AMICA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cell adhesion molecule binding | PVRL3B;ITGB2;NLGN4Y;CADM4;ITGB1;LILRB2;CADM2;JUP;FGFR1 |
| integrin binding | EMP2;P4HB;ADAMTS5;FBLN1;VWF;SYK;ACTN3;SFRP2;TLN1 |
| protein homodimerization activity | BNIP3L;HARS2;LDB1;SNX2;EIF2AK3;SEPT12;IL12B;UGT1A9;LRRFIP1 |
AMICA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AMICA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AMICA1.
CXADR; yscP; q7cit1_yerpe; q81t40_bacan
- Q&As
- Reviews
Q&As (10)
Ask a questionActivation of AMICA1 triggers downstream signaling pathways, such as Rho GTPases, PI3K/AKT, or MAPK/ERK, which modulate cytoskeletal rearrangement, cell survival, and gene expression, impacting cellular functions.
AMICA1 contributes to the formation and maintenance of tissue architecture by promoting cell adhesion, regulating cell polarity, and facilitating tissue-specific cellular organization.
AMICA1 exhibits a tissue-specific expression pattern, with higher expression observed in epithelial tissues, neural tissues, and certain organs like the liver and kidney.
Targeting AMICA1 signaling or interaction with specific antibodies or small molecules holds potential as a therapeutic strategy for diseases associated with abnormal cell adhesion or tissue integrity.
AMICA1 interacts with various cell adhesion molecules, such as cadherins, integrins, or selectins, as well as extracellular matrix components like collagen or fibronectin, facilitating cell-cell and cell-matrix interactions.
AMICA1 can undergo post-translational modifications, including phosphorylation, glycosylation, or ubiquitination, which can affect its adhesive properties, intracellular signaling, or protein stability.
During development and tissue regeneration, AMICA1 expression is dynamically regulated, showing distinct spatiotemporal patterns that coincide with tissue remodeling and organogenesis.
AMICA1 plays a crucial role in cell-cell adhesion and cell migration processes, promoting the formation of stable intercellular junctions and regulating cellular movement and tissue morphogenesis.
Dysregulation of AMICA1 expression or function has been implicated in various diseases, including cancer metastasis, epithelial barrier dysfunction, or neurodevelopmental disorders, underscoring its involvement in disease pathogenesis.
Modulation of AMICA1 expression or activity can influence cellular phenotypes, including cell proliferation, differentiation, and cell fate determination, highlighting its role in tissue homeostasis and development.
Customer Reviews (3)
Write a reviewCompatibility with complex biological matrices for translational research.
Enhanced assay sensitivity for detection of subtle protein changes.
Accurate determination of protein function and activity.
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