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JARID2

  • Official Full Name

    jumonji, AT rich interactive domain 2

  • Overview

    This gene is an ortholog of the mouse jumonji gene, which encodes a nuclear protein essential for mouse embryogenesis, including neural tube formation. Overexpression of mouse jumonji negatively regulates cell proliferation. The jumonji proteins contain a DNA-binding domain, called an AT-rich interaction domain (ARID), and share regions of similarity with human retinoblastoma-binding protein-2 and the human SMCX protein.
  • Synonyms

    JARID2; jumonji, AT rich interactive domain 2; JMJ, jumonji (mouse) homolog , Jumonji, AT rich interactive domain 2; protein Jumonji; JARD2; JARD2_HUMAN; JMJ; Jumonji AT rich interactive domain 2; Jumonji protein; Jumonji/ARID domain containing protein 2; Jumonji/ARID domain-containing protein 2; jumonji homolog; OTTHUMP00000016058; jumonji-like protein;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • E.coli
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human JARID2-27632TH Recombinant Human JARID2 Wheat Germ N/A 100 amino acids
Human JARID2-2976H Recombinant Human JARID2 protein, His-tagged E.coli His 1130-1228 aa
Mouse JARID2-8416M Recombinant Mouse JARID2 Protein Mammalian Cell His
Mouse JARID2-4672M Recombinant Mouse JARID2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse JARID2-4672M-B Recombinant Mouse JARID2 Protein Pre-coupled Magnetic Beads HEK293
Chicken JARID2-2081C Recombinant Chicken JARID2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • JARID2 Related Articles

JARID2 involved in several pathways and played different roles in them. We selected most pathways JARID2 participated on our site, such as Epigenetic regulation of gene expression, Gene Expression, PRC2 methylates histones and DNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with JARID2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Epigenetic regulation of gene expressionSUZ12B;DNMT3A;EED;TAF1B;CD3EAP;SAP130;SUZ12A;PHF1;H3F3D
Gene ExpressionGTF3C5;DNMT1;MTA1;ZKSCAN4;C2orf29;PTBP1A;ZNF496;DDOST;QTRT1
PRC2 methylates histones and DNAPHF1;PHF19;JARID2;JARID2B;MTF2;AEBP2
Signaling pathways regulating pluripotency of stem cellsBMP2;WNT8A;PIK3CA;LIF;SOX2;ESX1;MEIS1;PIK3R2;IGF1

JARID2 has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding, chromatin binding, NOT histone demethylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by JARID2 itself. We selected most functions JARID2 had, and list some proteins which have the same functions with JARID2. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II regulatory region sequence-specific DNA bindingRELB;TBX20;ATF2;PRKCBP1L;E2F7;NFIL3;ATF4B2;ZBTB11;ZNF691
chromatin bindingEP300;SKI;TOX2;SP140;SMC1AL;POU4F2;ING2;POU1F1;HDGFRP2
NOT histone demethylase activityJARID2B;JARID2
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific bindingKLF6A;FERD3L;E2F7;BCL6;BCL6A;CGGBP1;SATB1;AEBP1;ETV7

JARID2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with JARID2 here. Most of them are supplied by our site. Hope this information will be useful for your research of JARID2.

Ttll7; EED; ALB; CUL4B; EZH2; DDB1

Seok, HY; Chen, JH; et al. Loss of MicroRNA-155 Protects the Heart From Pathological Cardiac Hypertrophy. CIRCULATION RESEARCH 114:1585-1595(2014).
Zheng, WP; Huang, YJ; et al. The chemistry and biology of the alpha-ketoglutarate-dependent histone N-epsilon-methyl-lysine demethylases. MEDCHEMCOMM 5:297-313(2014).
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