jarid2
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  • Official Full Name
  • jumonji, AT rich interactive domain 2
  • Background
  • This gene is an ortholog of the mouse jumonji gene, which encodes a nuclear protein essential for mouse embryogenesis, including neural tube formation. Overexpression of mouse jumonji negatively regulates cell proliferation. The jumonji proteins contain a DNA-binding domain, called an AT-rich interaction domain (ARID), and share regions of similarity with human retinoblastoma-binding protein-2 and the human SMCX protein.
  • Synonyms
  • JARID2; jumonji, AT rich interactive domain 2; JMJ, jumonji (mouse) homolog , Jumonji, AT rich interactive domain 2; protein Jumonji; JARD2; JARD2_HUMAN; JMJ; Jumonji AT rich interactive domain 2; Jumonji protein; Jumonji/ARID domain containing protein 2; Jumonji/ARID domain-containing protein 2; jumonji homolog; OTTHUMP00000016058; jumonji-like protein
Cat.#:JARID2-27632THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human JARID2
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Cat.#:JARID2-8416MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse JARID2 Protein
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Cat.#:JARID2-2081CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken JARID2
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Involved Pathway

JARID2 involved in several pathways and played different roles in them. We selected most pathways JARID2 participated on our site, such as Epigenetic regulation of gene expression, Gene Expression, PRC2 methylates histones and DNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with JARID2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Epigenetic regulation of gene expression
SIN3B; RBB4L; SAP130; H3F3D; H3F3B.1; PHF1; AEBP2; BAZ2A; CD3EAP; TET1
Gene Expression
SF3B4; PIWIL4; ZNF213; NR1D2B; ZFP30; ZNF114; ZNF710; PUS1; ZNF750; SETA
PRC2 methylates histones and DNA
PHF1; JARID2B; AEBP2; JARID2; PHF19; MTF2
Signaling pathways regulating pluripotency of stem cells
HAND1; AXIN2; HOXB1; PCGF5; PIK3R5; AXIN1; WNT8B; SMAD5; DLX5; INHBC

Protein Function

JARID2 has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding, chromatin binding, NOT histone demethylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by JARID2 itself. We selected most functions JARID2 had, and list some proteins which have the same functions with JARID2. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase II regulatory region sequence-specific DNA binding
Related Protein EGR1; HSF2; ETV3; HOXD8; ZNF583; GLIS1; RXRA; ZFAT; ZNF256; AASS
Function chromatin binding
Related Protein YAP1; MKRN1; TBL1Y; MBD1; HDAC7; ASCL1; GATA3; PARP1; REST; POLG
Function NOT histone demethylase activity
Related Protein JARID2B; JARID2
Function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
Related Protein BCL6; MITF; NFKB1; ETV7; ARID5B; KLF12; JARID2; FOXD3; BCL6AB; NR2F6

Interacting Protein

JARID2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with JARID2 here. Most of them are supplied by our site. Hope this information will be useful for your research of JARID2.
Ttll7; EED; ALB; CUL4B; EZH2; DDB1

JARID2 Related Articles

Seok, HY; Chen, JH; et al. Loss of MicroRNA-155 Protects the Heart From Pathological Cardiac Hypertrophy. CIRCULATION RESEARCH 114:1585-1595(2014).
Zheng, WP; Huang, YJ; et al. The chemistry and biology of the alpha-ketoglutarate-dependent histone N-epsilon-methyl-lysine demethylases. MEDCHEMCOMM 5:297-313(2014).