Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953 Learn More

KCNB1

Official Full Name

potassium voltage-gated channel, Shab-related subfamily, member 1
Overview

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel and its activity is modulated by some other family members.
Synonyms

KCNB1; potassium voltage-gated channel, Shab-related subfamily, member 1; potassium voltage-gated channel subfamily B member 1; Kv2.1; Delayed rectifier potassium channel 1; Delayed rectifier potassium channel Kv2.1; DRK 1; DRK1; h DRK1 K(+) channel; h-DRK1; hDRK 1; hDRK1; KCB 1; KCB1; KCNB1_HUMAN; Potassium channel protein DRK1; Potassium voltage gated channel shab related subfamily member 1; Voltage-gated potassium channel subunit Kv2.1; OTTHUMP00000031697; h-DRK1 K(+) channel;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat
Rhesus Macaque

Source

HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	KCNB1-5071HCL	Recombinant Human KCNB1 293 Cell Lysate	HEK293	N/A	Inquiry
Mouse	KCNB1-8481M	Recombinant Mouse KCNB1 Protein	Mammalian Cell	His	Inquiry
Mouse	KCNB1-4722M-B	Recombinant Mouse KCNB1 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Mouse	KCNB1-4722M	Recombinant Mouse KCNB1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Rat	KCNB1-3172R	Recombinant Rat KCNB1 Protein	Mammalian Cell	His	Inquiry
Rat	KCNB1-2828R	Recombinant Rat KCNB1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Rat	KCNB1-2828R-B	Recombinant Rat KCNB1 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Rhesus Macaque	KCNB1-2347R	Recombinant Rhesus monkey KCNB1 Protein, His-tagged	Mammalian Cell	His	Inquiry
Rhesus Macaque	KCNB1-2168R	Recombinant Rhesus Macaque KCNB1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Rhesus Macaque	KCNB1-2168R-B	Recombinant Rhesus Macaque KCNB1 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry

Involved Pathway
Protein Function
Interacting Protein
KCNB1 Related Articles

KCNB1 involved in several pathways and played different roles in them. We selected most pathways KCNB1 participated on our site, such as Calcium Regulation in the Cardiac Cell, Integration of energy metabolism, Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Calcium Regulation in the Cardiac Cell	RGS14;RGS7;GJA4;GJA10;GJB2;GNB5B;CX44.1;YWHAQ;CASQ1B
Integration of energy metabolism	KCNJ11;RAPGEF3;KCNS3;RAPGEF4;KCNC2;GNG13B;MARCKSA;KCNS3A;ARL2BP
Metabolism	NUBP1;DCK;CYP8B2;HS3ST6;CYGB;C2orf56;DCT;ZDHHC21;SULT1ST5
Neuronal System	LIN7B;KCNA1;GLS2B;STXBP1A;CHRNA1;KCNK3A;KCNA10;DLG1L;SLC1A2A
Potassium Channels	KCNJ1A.4;KCNJ1A.5;KCNJ1A.6;KCNB1;KCNA2;KCNH8;KCNA4;KCNK10B;KCNAB2
Regulation of insulin secretion	MARCKSA;SYT5;KCNB1;KCNC2;KCNS3;ARL2BP;KCNS3A;MARCKSB;ARL2
Taste transduction	TAS2R38;TAS2R126;GNAT3;KCNB1;TAS2R20;TAS2R103;TAS2R143;PRKACA;TAS2R134

KCNB1 has several biochemical functions, for example, delayed rectifier potassium channel activity, ion channel binding, outward rectifier potassium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNB1 itself. We selected most functions KCNB1 had, and list some proteins which have the same functions with KCNB1. You can find most of the proteins on our site.

Function	Related Protein
delayed rectifier potassium channel activity	KCNQ2A;KCNV2B;KCND1;KCNV2;KCNQ5;KCNC1;KCNC1A;KCNA1;KCNC3A
ion channel binding	FGF13;PACS2;HERPUD1;AKAP9;PKP2;AKAP6;ACTN1;GPD1L;CIB1
outward rectifier potassium channel activity	KCNK2B;KCNA5;KCNB1;KCNQ1;KCNK5B;REST;KCNK2;KCNK1A;KCNK18
protein N-terminus binding	STXBP1;BIRC2;APTX;CHMP6;RPA2;PHB2;HAX1;DCTN4;STX5
protein binding	TTI1;KLRB1F;JUB;HNRNPK;PIK3R1;HDGFRP2;LSM4;GABPA;ASF1B
protein heterodimerization activity	CASP8;TAS1R2;TCF3A;HIST1H3A;SNX1;BCL2;PPP1CBL;HEXA;TAF11
ubiquitin-like protein binding	KCNB1;DCUN1D3;DCUN1D5;DCUN1D4;DCUN1D2;DCUN1D2B;DCUN1D2A;DCUN1D1;TCHP

KCNB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNB1.

tx1_strgf

Vandendriessche, T; Kopljar, I; et al. Purification, molecular cloning and functional characterization of HelaTx1 (Heterometrus laoticus): The first member of a new kappa-KTX subfamily. BIOCHEMICAL PHARMACOLOGY 83:1307-1317(2012).