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KCNE3

Official Full Name

potassium voltage-gated channel, Isk-related family, member 3
Overview

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the kidney. A missense mutation in this gene is associated with hypokalemic periodic paralysis.
Synonyms

KCNE3; potassium voltage-gated channel, Isk-related family, member 3; potassium voltage-gated channel subfamily E member 3; HOKPP; MiRP2; minK-related peptide 2; potassium channel subunit beta MiRP2; voltage-gated K+ channel subunit MIRP2; minimum potassi;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Rat

Source

E.coli
HEK293
Mammalian Cell

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	KCNE3-697H	Recombinant Human KCNE3	Mammalian Cell	His		Inquiry
Human	KCNE3-241H	Recombinant Human KCNE3, GST-tagged	E.coli	GST	1-103aa	$319 / 25ug
Human	KCNE3-5064HCL	Recombinant Human KCNE3 293 Cell Lysate	HEK293	N/A		Inquiry
Human	KCNE3-3191H	Recombinant Human KCNE3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Human	KCNE3-3191H-B	Recombinant Human KCNE3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	KCNE3-3179R	Recombinant Rat KCNE3 Protein	Mammalian Cell	His		Inquiry
Rat	KCNE3-2835R-B	Recombinant Rat KCNE3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	KCNE3-2835R	Recombinant Rat KCNE3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry

Involved Pathway
Protein Function
Interacting Protein

KCNE3 involved in several pathways and played different roles in them. We selected most pathways KCNE3 participated on our site, such as Protein digestion and absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNE3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Protein digestion and absorption	CELA2B;COL18A1;CPA1;SLC36A1;COL24A1;PGA5;DPP4;COL6A4;ATP1B2

KCNE3 has several biochemical functions, for example, potassium channel regulator activity, protein binding, voltage-gated potassium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNE3 itself. We selected most functions KCNE3 had, and list some proteins which have the same functions with KCNE3. You can find most of the proteins on our site.

Function	Related Protein
potassium channel regulator activity	KCNE2;DRD4;KCNIP2;AKAP9;KCNAB3;KCNE1;KCNAB1;CHP;SGK2
protein binding	ZNF473;SPHK2;C2orf29;STK11;TRIM39;IER3;ZMYND11;CDH1;KLHL6
voltage-gated potassium channel activity	KCNA4;KCNA1;KCNV2B;HTR3A;KCNH2A;KCNK9;KCNH5A;KCNA2;KCNF1A

KCNE3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNE3 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNE3.

GAPDH; QARS; EEF1A1; KIF5A; POLA2; LRIF1; GOLM1; SLC44A1; C11orf68; RASSF1