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KCNG4

  • Official Full Name

    potassium voltage-gated channel, subfamily G, member 4

  • Overview

    Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member functions as a modulatory subunit. The gene has strong expression in brain. Multiple alternatively spliced variants have been found in normal and cancerous tissues.
  • Synonyms

    KCNG4; potassium voltage-gated channel, subfamily G, member 4; potassium voltage-gated channel subfamily G member 4; Kv6.4; voltage-gated potassium channel Kv6.3; voltage-gated potassium channel subunit Kv6.4; KV6.3; MGC4558; MGC129609;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • E.coli expression system
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human KCNG4-5061HCL Recombinant Human KCNG4 293 Cell Lysate HEK293 N/A
Mouse KCNG4-8497M Recombinant Mouse KCNG4 Protein Mammalian Cell His
Mouse KCNG4-4731M Recombinant Mouse KCNG4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse KCNG4-4731M-B Recombinant Mouse KCNG4 Protein Pre-coupled Magnetic Beads HEK293
Homo sapiens (Human) RFL723HF Recombinant Full Length Human Potassium Voltage-Gated Channel Subfamily G Member 4(Kcng4) Protein, His-Tagged E.coli expression system His Full Length (1-519)
Mus musculus (Mouse) RFL32178MF Recombinant Full Length Mouse Potassium Voltage-Gated Channel Subfamily G Member 4(Kcng4) Protein, His-Tagged E.coli expression system His Full Length (1-506)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • KCNG4 Related Articles

KCNG4 involved in several pathways and played different roles in them. We selected most pathways KCNG4 participated on our site, such as Metabolic pathways, Metabolism, Metabolism of vitamins and cofactors, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNG4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Metabolic pathwaysACOT2;ETNK2;ATP5C1;CCBL2;NANP;ALOX12B;HAL;PCXB;ATP5I
MetabolismCYP2A7;SLC5A9;PHOSPHO1;DCK;ADH8B;CKMT1B;SGMS2;CYP2B6;NUDT3B
Metabolism of vitamins and cofactorsSLC52A3;SLC2A3;LOC100686744;NAMPT;SLC5A6B;SLC25A32B;PDZD11;TCN1;GSTO2
Metabolism of water-soluble vitamins and cofactorsSLC5A6A;ELA2;SLC25A16;GPHNA;GSTO2;SLC19A2;SLC25A32;CTRC;SLC46A1
Nicotinamide salvaging
Nicotinate and nicotinamide metabolismNT5C3L;AOX3;PNP6;AOX1;NT5E;CD38;PNP;NT5C1B;ITGB1BP3
Nicotinate metabolism

KCNG4 has several biochemical functions, for example, ligase activity, nicotinate phosphoribosyltransferase activity, nicotinate-nucleotide diphosphorylase (carboxylating) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNG4 itself. We selected most functions KCNG4 had, and list some proteins which have the same functions with KCNG4. You can find most of the proteins on our site.

Function Related Protein
ligase activityRNF217;RTCB;UBOX5;ZNRF2;TRIM27;GLULA;UBE3A;CBLC;UBE2D1A
nicotinate phosphoribosyltransferase activityKCNG4;NAPRT;NAPRT1
nicotinate-nucleotide diphosphorylase (carboxylating) activityKCNG4;NAMPT;NAMPTB;NAPRT;QPRT;NAPRT1
protein bindingMIS18BP1;PVRL3;SYCE3;NAV2;GP1BB;NLRP12;SESTD1;GAGE8;AZGP1

KCNG4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNG4 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNG4.

Been, LF; Ralhan, S; et al. Variants in KCNQ1 increase type II diabetes susceptibility in South Asians: A study of 3,310 subjects from India and the US. BMC MEDICAL GENETICS 12:-(2011).
Miceli, F; Cilio, MR; et al. Gating currents from neuronal K(V)7.4 channels General features and correlation with the ionic conductance. CHANNELS 3:274-283(2009).
Christie, MJ; et al. Molecular and functional diversity of K+ channels. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY 22:944-951(1995).
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