kcng4
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  • Official Full Name
  • potassium voltage-gated channel, subfamily G, member 4
  • Background
  • Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member functions as a modulatory subunit. The gene has strong expression in brain. Multiple alternatively spliced variants have been found in normal and cancerous tissues.
  • Synonyms
  • KCNG4; potassium voltage-gated channel, subfamily G, member 4; potassium voltage-gated channel subfamily G member 4; Kv6.4; voltage-gated potassium channel Kv6.3; voltage-gated potassium channel subunit Kv6.4; KV6.3; MGC4558; MGC129609
Cat.#:KCNG4-8497MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse KCNG4 Protein
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Cat.#:KCNG4-5061HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human KCNG4 293 Cell Lysate
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Involved Pathway

KCNG4 involved in several pathways and played different roles in them. We selected most pathways KCNG4 participated on our site, such as Metabolic pathways, Metabolism, Metabolism of vitamins and cofactors, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNG4 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Metabolic pathways
CYP2A4; AGPAT3; GSS; BTD; GLDC; NADK2; NDUFAB1A; ADOB; NANP; AANAT
Metabolism
SLC5A2; MTP; UCP2; GLTPA; CYP2AD2; COX10; CYP2S1; G0S2; SLC35D1A; NFYBB
Metabolism of vitamins and cofactors
SLC5A6A; PDZD11; SLC52A3; MMADHC; ELA2; CYB5A; SLC19A2; SLC25A16; CBLC-1; SLC2A3
Metabolism of water-soluble vitamins and cofactors
SLC5A6B; SLC19A2; SLC52A3; GSTO2; CTRB1; ELA2L; ELA2; KCNG4; SLC2A3; CYB5R3
Nicotinamide salvaging
KCNG4
Nicotinate and nicotinamide metabolism
NT5C3A; BST1; AOX3; PNP5A; MIBP2; QPRT; NAMPTB; NT5C1B; NADK2; NADKA
Nicotinate metabolism
KCNG4

Protein Function

KCNG4 has several biochemical functions, for example, ligase activity, nicotinate phosphoribosyltransferase activity, nicotinate-nucleotide diphosphorylase (carboxylating) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNG4 itself. We selected most functions KCNG4 had, and list some proteins which have the same functions with KCNG4. You can find most of the proteins on our site.
Function
Related Protein
Function ligase activity
Related Protein NSMCE1; RAD18; GLULA; MARCH3; UBE4B; NEDD4L; MARCH9; DTX3L; RNF19B; HECW1B
Function nicotinate phosphoribosyltransferase activity
Related Protein NAPRT; KCNG4; NAPRT1
Function nicotinate-nucleotide diphosphorylase (carboxylating) activity
Related Protein NAMPT; NAPRT; NAMPTB; QPRT; KCNG4; NAPRT1
Function protein binding
Related Protein NXF2; BUB3; FES; NGFRB; ANXA6; PLCB1; TFAP2C; TGS1; JIP1; ZNF460

KCNG4 Related Articles

Been, LF; Ralhan, S; et al. Variants in KCNQ1 increase type II diabetes susceptibility in South Asians: A study of 3,310 subjects from India and the US. BMC MEDICAL GENETICS 12:-(2011).
Miceli, F; Cilio, MR; et al. Gating currents from neuronal K(V)7.4 channels General features and correlation with the ionic conductance. CHANNELS 3:274-283(2009).
Christie, MJ; et al. Molecular and functional diversity of K+ channels. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY 22:944-951(1995).