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KCNIP1

Official Full Name

Kv channel interacting protein 1
Overview

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Alternative splicing results in multiple transcript variant encoding different isoforms.
Synonyms

KCNIP1; Kv channel interacting protein 1; Kv channel-interacting protein 1; KCHIP1; vesicle APC-binding protein; potassium channel interacting protein 1; potassium channel-interacting protein 1; A-type potassium channel modulatory protein 1; VABP; MGC95;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat

Source

E.coli
HEK293
HEK293T
Mammalian Cell

Tag

His
His (Fc)
Avi
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	KCNIP1-28452TH	Recombinant Human KCNIP1, His-tagged	E.coli	His		Inquiry
Human	KCNIP1-5056HCL	Recombinant Human KCNIP1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	KCNIP1-3225H	Recombinant Human KCNIP1 protein, His-tagged	E.coli	His	1-216 aa	$319 / 25ug
Mouse	KCNIP1-8506M	Recombinant Mouse KCNIP1 Protein	Mammalian Cell	His		Inquiry
Mouse	Kcnip1-3657M	Recombinant Mouse Kcnip1 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Mouse	KCNIP1-4734M	Recombinant Mouse KCNIP1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	KCNIP1-4734M-B	Recombinant Mouse KCNIP1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	KCNIP1-3190R	Recombinant Rat KCNIP1 Protein	Mammalian Cell	His		Inquiry
Rat	KCNIP1-2846R	Recombinant Rat KCNIP1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	KCNIP1-2846R-B	Recombinant Rat KCNIP1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
KCNIP1 Related Articles

KCNIP1 involved in several pathways and played different roles in them. We selected most pathways KCNIP1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNIP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

KCNIP1 has several biochemical functions, for example, calcium ion binding, ion channel binding, potassium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNIP1 itself. We selected most functions KCNIP1 had, and list some proteins which have the same functions with KCNIP1. You can find most of the proteins on our site.

Function	Related Protein
calcium ion binding	GUCA1G;CBL;S100Z;PCDHB11;DSG4;SYTL2;PCDHB15;THBS3A;SLC25A25
ion channel binding	FGF13;AKAP9;CALM3;KCNC1;PRKCSH;PPP1R9B;CAMK2D;RYR2;RANGRF
potassium channel activity	TMEM38B;KCNV2;FXYD4;KCNIP1;KCNC1A;KCNC3A;KCNK15;KCNH5;KCNK13B
potassium channel regulator activity	PIAS3;SGK1;DLG1;KCNIP2;ADRB2;SGK3;KCNE1;SGK2A;CHP
protein N-terminus binding	ZWINT;HAX1;MYO7A;PDLIM5;RPA3;GTF2H2;SNCA;SLC6A3;RASSF1
protein binding	ITGA2B;TPRGL;ELOVL6;ESRP1;C1orf65;TPD52L3;APOD;WIF1;GP5
protein heterodimerization activity	SDCBP2;HIST4H4;KCNK9;P2RY1;TLX1;PPARD;DMRT3;H2AFB1;CRLF1
voltage-gated ion channel activity	KCNJ1A.2;NALCN;KCNC1A;KCNG4A;CLCN3;TPCN1;ANO6;KCNC1B;TPC3

KCNIP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNIP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNIP1.

KCND3; KCND2; calcium(2+)

Choudhury, S; Schnell, M; et al. Antibodies Against Potassium Channel Interacting Protein 2 Induce Necrosis in Isolated Rat Cardiomyocytes. JOURNAL OF CELLULAR BIOCHEMISTRY 115:678-689(2014).

Menegola, M; Clark, E; et al. The importance of immunohistochemical analyses in evaluating the phenotype of Kv channel knockout mice. EPILEPSIA 53:142-149(2012).