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KCNJ1

  • Official Full Name

    potassium inwardly-rectifying channel, subfamily J, member 1

  • Overview

    Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Synonyms

    KCNJ1; potassium inwardly-rectifying channel, subfamily J, member 1; ROMK; ROMK1; KIR1.1; ATP-sensitive inward rectifier potassium channel 1; inwardly rectifying K+ channel; inward rectifier K(+) channel Kir1.1; ATP-regulated potassium channel ROM-K; potassium channel, inwardly rectifying subfamily J member 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • E.coli
  • E.coli expression system
  • E.Coli or Yeast
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human KCNJ1-28453TH Recombinant Human KCNJ1 Wheat Germ N/A 100 amino acids
Human KCNJ1-5049HCL Recombinant Human KCNJ1 293 Cell Lysate HEK293 N/A
Human KCNJ1-1431H Recombinant Human KCNJ1 Protein (178-391 aa), His-tagged Yeast His 178-391 aa
Human KCNJ1-596H Recombinant Human KCNJ1 Protein (178-391 aa), His-tagged E.coli His 178-391 aa
Mouse Kcnj1-3754M Recombinant Mouse Kcnj1, His-tagged E.Coli or Yeast His 372
Rat KCNJ1-3194R Recombinant Rat KCNJ1 Protein Mammalian Cell His
Rat KCNJ1-2850R Recombinant Rat KCNJ1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat KCNJ1-2850R-B Recombinant Rat KCNJ1 Protein Pre-coupled Magnetic Beads HEK293
Homo sapiens (Human) RFL22761HF Recombinant Full Length Human Atp-Sensitive Inward Rectifier Potassium Channel 1(Kcnj1) Protein, His-Tagged E.coli expression system His Full Length (1-391)
Mus musculus (Mouse) RFL19989MF Recombinant Full Length Mouse Atp-Sensitive Inward Rectifier Potassium Channel 1(Kcnj1) Protein, His-Tagged E.coli expression system His Full Length (1-372)
Rattus norvegicus (Rat) RFL30716RF Recombinant Full Length Rat Atp-Sensitive Inward Rectifier Potassium Channel 1(Kcnj1) Protein, His-Tagged E.coli expression system His Full Length (1-391)
  • Involved Pathway
  • Protein Function
  • Interacting Protein

KCNJ1 involved in several pathways and played different roles in them. We selected most pathways KCNJ1 participated on our site, such as Aldosterone-regulated sodium reabsorption, Gastric acid secretion, Inwardly rectifying K+ channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNJ1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Aldosterone-regulated sodium reabsorptionPRKCB;INS2;NEDD4L;INSR;PIK3CA;SCNN1B;ATP1B1;SCNN1G;ATP1B2
Gastric acid secretionSLC9A4;ATP1B4;PRKACA;KCNJ1;ATP1A3;Adcy4;CAMK2G;CAMK2B;PLCB4
Inwardly rectifying K+ channelsGNGT2B;KCNJ14;KCNJ1;KCNJ1A.1;KCNJ1A.3;KCNJ2A;KCNJ1A.4;KCNJ1B;KCNJ1A.5
Neuronal SystemKCNK13B;DLG1L;PANX1B;DLG3;KCNQ2;SYN1;KCNG1;KCNS2;KCNK1B
Potassium ChannelsKCNK6;KCNH6A;KCNK1A;KCNQ3;KCNQ1;KCNJ8;KCNN3;KCNC1A;KCNAB1
Potassium transport channelsKCNJ1A.4;KCNJ1A.6;KCNJ1A.5;KCNJ1A.1;KCNJ1A.2;KCNJ1A.3;KCNJ1B;KCNJ1

KCNJ1 has several biochemical functions, for example, ATP binding, ATP-activated inward rectifier potassium channel activity, inward rectifier potassium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNJ1 itself. We selected most functions KCNJ1 had, and list some proteins which have the same functions with KCNJ1. You can find most of the proteins on our site.

Function Related Protein
ATP bindingUBE2E1;ABCA5;SHPRH;MKNK2A;OXSR1B;CCT6B;STK3;TYRO3;CKMT2A
ATP-activated inward rectifier potassium channel activityKCNJ11L;KCNJ10;KCNJ1A.6;KCNJ1A.4;KCNJ1A.2;KCNJ1A.1;KCNJ1A.3;KCNJ1;KCNJ8
inward rectifier potassium channel activityKCNJ14;KCNK6;KCNJ12;KCNJ16;KCNJ18;KCNJ1A.2;KCNJ1A.3;KCNK1;KCNJ1A.6
phosphatidylinositol-4,5-bisphosphate bindingFAM123B;ADAP2;RPH3A;TWF2;TULP1;RS1;KCNJ2;MARK1;ALOX15

KCNJ1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNJ1 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNJ1.

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