kcnj2
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  • Official Full Name
  • potassium inwardly-rectifying channel, subfamily J, member 2
  • Background
  • Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Mutations in this gene have been associated with Andersen syndrome, which is characterized by periodic paralysis, cardiac arrhythmias, and dysmorphic features. [provided by RefSeq, Jul 2008]
  • Synonyms
  • KCNJ2; potassium inwardly-rectifying channel, subfamily J, member 2; IRK1; LQT7; SQT3; ATFB9; HHIRK1; KIR2.1; HHBIRK1; inward rectifier potassium channel 2; IRK-1; hIRK1; inward rectifier K+ channel KIR2.1; cardiac inward rectifier potassium channel;
Cat.#:KCNJ2-27881THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human KCNJ2
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Cat.#:KCNJ2-8517MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse KCNJ2 Protein
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Cat.#:KCNJ2-3200RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat KCNJ2 Protein
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Cat.#:KCNJ2-2359RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey KCNJ2 Protein, His-tagged
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Cat.#:KCNJ2-6922CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken KCNJ2
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Cat.#:CSC-RI0115Tag:
Source (Host):Species:Human
Product nameHuman KCNJ2 Stable Cell Line-HEK293
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Cat.#:CSC-RI0116Tag:
Source (Host):Species:Human
Product nameHuman KCNJ2 Stable Cell Line-CHO
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Cat.#:CSC-RI0117Tag:
Source (Host):Species:Human
Product nameHuman KCNJ2 Stable Cell Line-CHO
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Cat.#:CSC-RI0118Tag:
Source (Host):Species:Human
Product nameHuman KCNJ2 Stable Cell Line-HEK293
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Involved Pathway

KCNJ2 involved in several pathways and played different roles in them. We selected most pathways KCNJ2 participated on our site, such as Activation of G protein gated Potassium channels, Activation of GABAB receptors, Cholinergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNJ2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Activation of G protein gated Potassium channels
KCNJ2; KCNJ6; GNGT2B; GNB3A; KCNJ3; KCNJ4; KCNJ15; KCNJ12; GNGT2A; KCNJ5
Activation of GABAB receptors
KCNJ4; ADCY9; ADCY8; KCNJ5; ADCY7; GNB3B; KCNJ3; ADCY1; ADCY3; KCNJ10
Cholinergic synapse
CREB3L3; GNAQ; AKT2; GNAI1; GNG3; CHRM3; GNB3; PRKCB; FOS; CHRM4
Classical Kir channels
KCNJ4; KCNJ14; KCNJ12; KCNJ2; KCNJ2A
G protein gated Potassium channels
KCNJ9; GNB3B; KCNJ2; KCNJ10; KCNJ4; KCNJ6; KCNJ15; GNB3A; KCNJ5; GNGT2A
GABA B receptor activation
GNGT2B; KCNJ12; KCNJ15; GNB3A; KCNJ6; KCNJ9; KCNJ2; KCNJ4; KCNJ10; GNGT2A
GABA receptor activation
KCNJ2A; GNGT2A; KCNJ2; KCNJ12; GNGT2B; ARHGEF9; KCNJ10; KCNJ15; KCNJ4; GABRR2A
Gastric acid secretion
KCNJ10; ATP1B2; ATP1A4; MYLK2; SSTR2; KCNQ1; SLC26A7; CAMK2B; EZR; GNAS

Protein Function

KCNJ2 has several biochemical functions, for example, identical protein binding, inward rectifier potassium channel activity, phosphatidylinositol-4,5-bisphosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNJ2 itself. We selected most functions KCNJ2 had, and list some proteins which have the same functions with KCNJ2. You can find most of the proteins on our site.
Function
Related Protein
Function identical protein binding
Related Protein FHIT; MMP9; AMELX; RB1; TRIM8; BTK; RYR2; STK10; ATG101; KCNJ2
Function inward rectifier potassium channel activity
Related Protein KCNJ1A.4; KCNJ1A.6; KCNQ5; KCNJ1A.2; KCNH2; KCNJ15; KCNJ4; KCNJ18; KCNJ2A; KCNJ1A.5
Function phosphatidylinositol-4,5-bisphosphate binding
Related Protein ANXA8; TWF1; FAM123A; MYO1G; PFN2; CHMP3; MAPKAP1; RAB35; TULP1; FAM21C
Function voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
Related Protein KCNQ1; KCNJ2

Interacting Protein

KCNJ2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNJ2 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNJ2.
FLNA; AKAP5

KCNJ2 Related Articles

Serratrice, G; Pellisser, JF; et al. Potassium channelopathies and Morvan's syndromes. BULLETIN DE L ACADEMIE NATIONALE DE MEDECINE 194:391-406(2010).