kcnj8
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  • Official Full Name
  • potassium inwardly-rectifying channel, subfamily J, member 8
  • Background
  • Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins.
  • Synonyms
  • KCNJ8; potassium inwardly-rectifying channel, subfamily J, member 8; ATP-sensitive inward rectifier potassium channel 8; Kir6.1; inward rectifier K(+) channel Kir6.1; inwardly rectifying potassium channel KIR6.1; potassium channel, inwardly rectifying sub
Cat.#:KCNJ8-260HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human KCNJ8, GST-tagged
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Cat.#:Kcnj8-3760MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse Kcnj8, His-tagged
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Cat.#:KCNJ8-8522MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse KCNJ8 Protein
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Cat.#:KCNJ8-3204RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat KCNJ8 Protein
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Cat.#:KCNJ8-2361RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey KCNJ8 Protein, His-tagged
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Cat.#:KCNJ8-5572CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken KCNJ8
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Cat.#:KCNJ8-3266ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish KCNJ8
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Cat.#:KCNJ8-5043HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human KCNJ8 293 Cell Lysate
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Involved Pathway

KCNJ8 involved in several pathways and played different roles in them. We selected most pathways KCNJ8 participated on our site, such as ATP sensitive Potassium channels, Inwardly rectifying K+ channels, Neuronal System, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNJ8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ATP sensitive Potassium channels
ABCC9; KCNJ11; KCNJ8
Inwardly rectifying K+ channels
KCNJ1A.1; KCNJ11; KCNJ10; KCNJ8; GNGT2B; GNGT2A; KCNJ1A.6; KCNJ14; KCNJ1A.4; KCNJ2A
Neuronal System
RAB3AB; KCNK2; KCNJ1A.6; CHRNA4; CHRNA2; CHRNB2; KCNV2; NCALDA; KCNMA1; PPFIA2
Potassium Channels
KCNJ1B; KCNA10; KCNMB2; KCNG4A; KCNK4; KCNK1B; DDX1; KCNK16; KCNK6; KCND1
SIDS Susceptibility Pathways
POU2F2; MECP2; TPH2; PKNOX1; SST; SNTA1; MAZ; EN1; YBX1; GATA2
cGMP-PKG signaling pathway
NFATC3; MYLK; AKT2; ATP1B3; IRS1; PPP1R12A; ATP1A3; MEF2D; PPP1CB; CALM1

Protein Function

KCNJ8 has several biochemical functions, for example, ATP binding, ATP-activated inward rectifier potassium channel activity, NOT G-protein activated inward rectifier potassium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNJ8 itself. We selected most functions KCNJ8 had, and list some proteins which have the same functions with KCNJ8. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein TARS; MAP2K4; MYO6B; DDR2; CDKL3; NADK; ACVR1BA; DQX1; CDK1; PKMYT1
Function ATP-activated inward rectifier potassium channel activity
Related Protein KCNJ1B; KCNJ1A.4; KCNJ1A.5; KCNJ1A.1; KCNJ1; KCNJ1A.6; KCNJ8; KCNJ1A.2; KCNJ1A.3; KCNJ11L
Function NOT G-protein activated inward rectifier potassium channel activity
Related Protein KCNJ11; KCNJ11L; KCNJ8
Function inward rectifier potassium channel activity
Related Protein KCNQ5; KCNJ11L; KCNJ4; KCNK6; KCNJ12; KCNJ16; KCNJ1; KCNJ13; KCNJ1A.4; KCNJ1B
Function sulfonylurea receptor binding
Related Protein HSP90AB1; KCNJ8

KCNJ8 Related Articles

Li, Q; Chen, M; et al. KCNJ11 E23K variant is associated with the therapeutic effect of sulphonylureas in Chinese type 2 diabetic patients. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY 41:748-754(2014).
Qin, LJ; Lv, Y; et al. Meta-analysis of association of common variants in the KCNJ11-ABCC8 region with type 2 diabetes. GENETICS AND MOLECULAR RESEARCH 12:2990-3002(2013).