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KCNK16

  • Official Full Name

    potassium channel, subfamily K, member 16

  • Overview

    The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is expressed predominantly in the pancreas and is activated at alkaline pH. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
  • Synonyms

    KCNK16; potassium channel, subfamily K, member 16; potassium channel subfamily K member 16; K2p16.1; TALK 1; TALK1; 2P domain potassium channel Talk-1; pancreatic potassium channel Talk-1; TWIK-related alkaline pH-activated K(+) channel 1; TALK-1; MGC1331;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human KCNK16-354HCL Recombinant Human KCNK16 lysate HEK293 N/A
Homo sapiens (Human) RFL5253HF Recombinant Full Length Human Potassium Channel Subfamily K Member 16(Kcnk16) Protein, His-Tagged E.coli expression system His Full Length (1-309)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • KCNK16 Related Articles

KCNK16 involved in several pathways and played different roles in them. We selected most pathways KCNK16 participated on our site, such as Neuronal System, Potassium Channels, TWIK-related alkaline pH activated K+ channel (TALK), which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNK16 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Neuronal SystemKCNMB2;SLC1A7B;RERG;PANX1;RAB3AA;KCNG1;SLC1A7A;KCNJ1B;KCNC3A
Potassium ChannelsKCNN1A;KCNK18;KCNA6;KCNJ1B;KCNK4;KCNA7;KCNF1A;ABCC9;KCNC1B
TWIK-related alkaline pH activated K+ channel (TALK)
Tandem pore domain potassium channelsKCNK13B;DDX1;KCNK16;KCNK2;KCNK18;KCNK1B;KCNK10B;KCNK7;KCNK6

KCNK16 has several biochemical functions, for example, potassium channel activity, potassium ion leak channel activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNK16 itself. We selected most functions KCNK16 had, and list some proteins which have the same functions with KCNK16. You can find most of the proteins on our site.

Function Related Protein
potassium channel activityKCNA2B;KCNK5B;KCNK1A;KCNA6A;KCNIP3;TMEM38B;KCNK5;KCNC4;KCNK16
potassium ion leak channel activityTMEM175;DDX1;KCNK18;KCNK1A;KCNK16;KCNK3A;KCNK5;KCNK9;KCNK7
protein bindingPPP4C;CASKIN1;ACAA1;STMN1;NOTCH3;FOXG1;KLB;KCNJ15;GTF2H2
voltage-gated ion channel activityKCNJ16;SCN12AB;CACNA2D3;GPR89;TMEM109;KCNJ11L;PKD2;KCNS3A;KCNK16

KCNK16 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNK16 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNK16.

OTX1

Lin, W; Burks, CA; et al. Taste receptor cells express pH-sensitive leak K+ channels. JOURNAL OF NEUROPHYSIOLOGY 92:2909-2919(2004).
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