kcnk4
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  • Official Full Name
  • potassium channel, subfamily K, member 4
  • Background
  • Potassium channels play a role in many cellular processes including maintenance of the action potential, muscle contraction, hormone secretion, osmotic regulation, and ion flow. This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The encoded protein homodimerizes and functions as an outwardly rectifying channel. It is expressed primarily in neural tissues and is stimulated by membrane stretch and polyunsaturated fatty acids.
  • Synonyms
  • KCNK4; potassium channel, subfamily K, member 4; potassium channel subfamily K member 4; K2p4.1; TRAAK; MGC144821; K2P4.1 potassium channel; KCNK 4; Potassium inwardly rectifying channel subfamily K member 4; TRAAK1; TRAAKt; TWIK related arachidonic acid stimulated potassium channel protein; Two pore K+ channel KT4.1; two pore K(+) channel KT4.1; two pore potassium channel KT4.1; TWIK-related arachidonic acid-stimulated potassium channel protein
Cat.#:KCNK4-8533MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse KCNK4 Protein
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Cat.#:KCNK4-5034HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human KCNK4 293 Cell Lysate
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Involved Pathway

KCNK4 involved in several pathways and played different roles in them. We selected most pathways KCNK4 participated on our site, such as Neuronal System, Potassium Channels, TWIK related potassium channel (TREK), which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNK4 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Neuronal System
KCNH6; KCNN1; KCNA4; KCNMA1; KCNS3A; RERG; SLC6A1A; KCNH5; SYN2; CACNG2B
Potassium Channels
KCNJ14; KCNF1; KCNH1B; KCNJ8; KCNJ1A.4; KCNC3A; KCND1; KCNK6; KCNK10B; KCNK13B
TWIK related potassium channel (TREK)
KCNK2B; KCNK4; KCNK2; KCNK10B
Tandem pore domain potassium channels
KCNK2B; KCNK10B; KCNK2; KCNK1A; KCNK13B; KCNK1; KCNK4; KCNK1B; KCNK18; DDX1

Protein Function

KCNK4 has several biochemical functions, for example, mechanically-gated potassium channel activity, potassium channel activity, potassium ion leak channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNK4 itself. We selected most functions KCNK4 had, and list some proteins which have the same functions with KCNK4. You can find most of the proteins on our site.
Function
Related Protein
Function mechanically-gated potassium channel activity
Related Protein KCNK4
Function potassium channel activity
Related Protein KCNQ3; KCNK2B; KCNK1; KCNK18; KCNK3A; KCNF1A; KCNA2B; KCNF1; AQP1; KCNC4
Function potassium ion leak channel activity
Related Protein TMEM175; KCNK2; KCNK1; KCNK5; KCNK10B; KCNK18; DDX1; KCNK13B; KCNK4; KCNK10
Function temperature-gated cation channel activity
Related Protein KCNK4; TRPA1
Function voltage-gated ion channel activity
Related Protein CLIC5B; CALHM1; CACNA2D3; TPCN1; TMEM37; CACNG8A; SCN4AB; CLCN3; SCN8AA; KCNG4A

Interacting Protein

KCNK4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNK4 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNK4.
RPL14; DIDO1

KCNK4 Related Articles

Wu, J; Wu, X; et al. Overexpression of potassium channel ether a go-go1 in human osteosarcoma. NEOPLASMA 59:207-215(2012).
Wang, L; Fyffe, REW; et al. Identification of a kv3.4 channel in corneal epithelial cells. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 45:1796-1803(2004).