kcnmb3
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  • Official Full Name
  • potassium large conductance calcium-activated channel, subfamily M beta member 3
  • Background
  • MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which may partially inactivate or slightly decrease the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 22.
  • Synonyms
  • KCNMB3; potassium large conductance calcium-activated channel, subfamily M beta member 3; KCNMB2, KCNMBL; calcium-activated potassium channel subunit beta-3; slo-beta-3; K(VCA)beta-3; BK channel subunit beta-3; maxi K channel subunit beta-3; charybdotoxin
Cat.#:KCNMB3-3217RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat KCNMB3 Protein
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Cat.#:KCNMB3-5023HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human KCNMB3 293 Cell Lysate
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Cat.#:KCNMB3-5024HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human KCNMB3 293 Cell Lysate
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Cat.#:KCNMB3-5025HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human KCNMB3 293 Cell Lysate
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Involved Pathway

KCNMB3 involved in several pathways and played different roles in them. We selected most pathways KCNMB3 participated on our site, such as cGMP-PKG signaling pathway, Vascular smooth muscle contraction, Insulin secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNMB3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
cGMP-PKG signaling pathway
SLC25A6; PIK3R3; PIK3R5; GNA12; BNP; KCNJ8; PPP1R12A; NPR2; OPRD1; PLCB1
Vascular smooth muscle contraction
PLA2G2D; ADORA2AB; PLA2G10; ROCK2; MYL6B; PRKCA; ROCK2B; PRKACG; GNAQ; PRKG1
Insulin secretion
GLP1R; PRKACA; PLCB1; GNA11; PRKCB; KCNN2; CAMK2A; TRPM4; RAPGEF4; PRKCG

Protein Function

KCNMB3 has several biochemical functions, for example, calcium-activated potassium channel activity, potassium channel regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNMB3 itself. We selected most functions KCNMB3 had, and list some proteins which have the same functions with KCNMB3. You can find most of the proteins on our site.
Function
Related Protein
Function calcium-activated potassium channel activity
Related Protein KCNMB3; KCNN1; KCNT1; KCNMA1A; KCNK18; KCNN1B; KCNMB4; KCNMB1; MTMR6; PKD2L1
Function potassium channel regulator activity
Related Protein KCNS3; KCNMB1; KCNMB2; SGK2A; SGK3; KCNIP3; KCNE2; DRD4; KCNIP4; SGK2