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KCNN1

  • Official Full Name

    potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1

  • Overview

    Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes.
  • Synonyms

    KCNN1; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1; small conductance calcium-activated potassium channel protein 1; hSK1; KCa2.1; KCNN 1; KCNN1_HUMAN; SK; SK1; SKCa 1; SKCa1; Small conductance calcium activated potassium channel protein 1;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • E.coli
  • E.coli expression system
  • HEK293
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human KCNN1-275H Recombinant Human KCNN1, GST-tagged E.coli GST 366-543aa
Mouse KCNN1-8542M Recombinant Mouse KCNN1 Protein Mammalian Cell His
Mouse KCNN1-4752M Recombinant Mouse KCNN1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse KCNN1-4752M-B Recombinant Mouse KCNN1 Protein Pre-coupled Magnetic Beads HEK293
Rat KCNN1-3218R Recombinant Rat KCNN1 Protein Mammalian Cell His
Rat KCNN1-2874R-B Recombinant Rat KCNN1 Protein Pre-coupled Magnetic Beads HEK293
Rat KCNN1-2874R Recombinant Rat KCNN1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Homo sapiens (Human) RFL2955HF Recombinant Full Length Human Small Conductance Calcium-Activated Potassium Channel Protein 1(Kcnn1) Protein, His-Tagged E.coli expression system His Full Length (1-543)
Mus musculus (Mouse) RFL27612MF Recombinant Full Length Mouse Small Conductance Calcium-Activated Potassium Channel Protein 1(Kcnn1) Protein, His-Tagged E.coli expression system His Full Length (1-537)
Rattus norvegicus (Rat) RFL31466RF Recombinant Full Length Rat Small Conductance Calcium-Activated Potassium Channel Protein 1(Kcnn1) Protein, His-Tagged E.coli expression system His Full Length (1-536)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • KCNN1 Related Articles

KCNN1 involved in several pathways and played different roles in them. We selected most pathways KCNN1 participated on our site, such as Ca2+ activated K+ channels, Insulin secretion, Neuronal System, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ca2+ activated K+ channelsKCNMB2;KCNMA1;KCNMB1;KCNN3;KCNN1A;KCNN1;KCNN2;KCNN4;KCNN1B
Insulin secretionPLCB1;ATF4;CREB3L3;PLCB4;GNAQ;KCNN2;ATP1A4;PRKACB;CREB3L1
Neuronal SystemSLC1A2A;KCNC3A;SYN1;KCNC4;KCNK4;CHRND;KCNJ1A.3;SLC1A3B;GNGT2B
Potassium ChannelsHCN4;KCNK1A;KCNA6A;KCNG1;KCNV1;KCNJ14;KCNA4;KCNH2;KCNC2

KCNN1 has several biochemical functions, for example, calcium-activated potassium channel activity, calmodulin binding, protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNN1 itself. We selected most functions KCNN1 had, and list some proteins which have the same functions with KCNN1. You can find most of the proteins on our site.

Function Related Protein
calcium-activated potassium channel activityKCNMB3;KCNN4;KCNMA1;KCNN1;KCNMB1;KCNMB2;CCT8L2;KCNN2;KCNMA1A
calmodulin bindingRASGRF2;EWSR1;MAP6;CAMK1D;KCNH1;CNN3;PNCK;CTH;PHKG1
protein heterodimerization activityHIST1H3D;ALX4;H2AFJ;PBX1;RRAGA;MAPK4;H3F3B.1;BNIP3L;UGT1A3
small conductance calcium-activated potassium channel activityKCNN1B;KCNN1;KCNN2;KCNN3;KCNN1A

KCNN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNN1.

GRB2

Kim, JJ; Park, YM; et al. Identification of KCNN2 as a susceptibility locus for coronary artery aneurysms in Kawasaki disease using genome-wide association analysis. JOURNAL OF HUMAN GENETICS 58:521-525(2013).
Chang, SH; Chang, SN; et al. Significant Association of rs13376333 in KCNN3 on Chromosome 1q21 With Atrial Fibrillation in a Taiwanese Population. CIRCULATION JOURNAL 76:184-188(2012).
Li, C; Wang, F; et al. Significant association of SNP rs2106261 in the ZFHX3 gene with atrial fibrillation in a Chinese Han GeneID population. HUMAN GENETICS 129:239-246(2011).
Mauler, F; Hinz, V; et al. Selective intermediate-/small-conductance calcium-activated potassium channel (KCNN4) blockers are potent and effective therapeutics in experimental brain oedema and traumatic brain injury caused by acute subdural haematoma. EUROPEAN JOURNAL OF NEUROSCIENCE 20:1761-1768(2004).
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