kcnq2
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  • Official Full Name
  • potassium voltage-gated channel, KQT-like subfamily, member 2
  • Background
  • The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Synonyms
  • KCNQ2; potassium voltage-gated channel, KQT-like subfamily, member 2; EBN; BFNC; EBN1; ENB1; BFNS1; EIEE7; HNSPC; KV7.2; KCNA11; KVEBN1; potassium voltage-gated channel subfamily KQT member 2; KQT-like 2; voltage-gated potassium channel subunit Kv7.2; neuroblastoma-specific potassium channel protein; neuroblastoma-specific potassium channel subunit alpha KvLQT2;
Cat.#:KCNQ2-3222RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat KCNQ2 Protein
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Cat.#:KCNQ2-5019HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human KCNQ2 293 Cell Lysate
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Cat.#:CSC-RI0145Tag:
Source (Host):Species:Human
Product nameHuman KCNQ2/KCNQ3 Stable Cell Line-HEK293
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Cat.#:CSC-RI0146Tag:
Source (Host):Species:Human
Product nameHuman KCNQ2/KCNQ4 Stable Cell Line-CHO
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Involved Pathway

KCNQ2 involved in several pathways and played different roles in them. We selected most pathways KCNQ2 participated on our site, such as Axon guidance, Cholinergic synapse, Developmental Biology, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNQ2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Axon guidance
PAK6; RHOD; EPHA10; CSNK2A2; EFNA3; MAPK3; CAP2; DPYSL3; GNAI2; EPHB3
Cholinergic synapse
GNG12; GNAI1; PRKACB; CHRNB2; PLCB1; SLC5A7; CAMK2B; PRKACA; PIK3CG; MAP2K1
Developmental Biology
NRP2; HFE2; DPYSL2B; DUSP9; STX1B; DUSP1; SPAG9; TDGF1; TRPC5; EFNA3
Interaction between L1 and Ankyrins
SCN3A; SCN9A; SCN4A; SCN8A; SCN3B; SCN2B; KCNQ3; SCN2A; KCNQ2; NADL1.1
L1CAM interactions
DCX; DPYSL2; CNTN6; SCN4A; CNTN1; KIF4A; DLG3; SCN3A; ANK2B; KCNQ3
Neuronal System
MYO6; KCNN1; SYT1A; KCNV2; SYN3; ABCC9; KCNMA1; BZRAP1; CHRND; KCND2
Potassium Channels
KCNK4; KCNK13A; KCNAB2B; KCNC1B; KCNA1; HCN4; KCNK18; KCNA4; KCNAB2; KCNQ2A
Voltage gated Potassium channels
KCNA10; KCNS2; KCNS3A; KCNC1; KCNH5; KCNAB3; KCNA4; KCNAB2; KCNH6; KCNA2B

Protein Function

KCNQ2 has several biochemical functions, for example, ankyrin binding, delayed rectifier potassium channel activity, potassium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNQ2 itself. We selected most functions KCNQ2 had, and list some proteins which have the same functions with KCNQ2. You can find most of the proteins on our site.
Function
Related Protein
Function ankyrin binding
Related Protein FLNC; PTBP3; RHCG; RHAG; SLC8A1; SLC4A1; SCN5A; SPTBN1; KCNJ11; NRCAM
Function delayed rectifier potassium channel activity
Related Protein KCNQ1; KCNA2; KCND1; KCNG3; KCNQ2; KCNS3A; KCNF1A; KCNG4A; KCNQ3; KCNH2
Function potassium channel activity
Related Protein TRPM5; KCNF1A; KCNIP4; KCNK18; KCNA2B; KCNC3A; KCNK1A; KCNA1; KCNG1; AQP1
Function protein N-terminus binding
Related Protein HAX1; ACTN4; TRAF6; VWF; NIPBL; SMARCE1; SNCA; RBPJ; RPA2; KCNB1
Function voltage-gated potassium channel activity
Related Protein KCNC3B; KCNC3A; KCNA2B; KCNAB2; KCNC2; KCNA6A; KCNH2; KCNAB2B; KCNAB3; CNGA5

Interacting Protein

KCNQ2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNQ2 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNQ2.
ARIH2

KCNQ2 Related Articles

Bocksteins, E; Van de Vijver, G; et al. K(v)3 channels contribute to the delayed rectifier current in small cultured mouse dorsal root ganglion neurons. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 303:C406-C415(2012).
Pulkes, T; Dejthevaporn, C; et al. Paroxysmal neuromyotonia: A new sporadic channelopathy. NEUROMUSCULAR DISORDERS 22:479-482(2012).