kdm1b
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  • Official Full Name
  • lysine (K)-specific demethylase 1B
  • Background
  • Flavin-dependent histone demethylases, such as KDM1B, regulate histone lysine methylation, an epigenetic mark that regulates gene expression and chromatin function (Karytinos et al., 2009 [PubMed 19407342]).[supplied by OMIM, Oct 2009]
  • Synonyms
  • KDM1B; lysine (K)-specific demethylase 1B; AOF1; LSD2; C6orf193; bA204B7.3; dJ298J15.2; lysine-specific histone demethylase 1B; amine oxidase, flavin containing 1; lysine-specific histone demethylase 2; amine oxidase (flavin containing) domain 1; flavin-containing amine oxidase domain-containing protein 1;
Cat.#:AOF1-642HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human AOF1 protein, GST-tagged
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Cat.#:KDM1B-8586MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse KDM1B Protein
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Involved Pathway

KDM1B involved in several pathways and played different roles in them. We selected most pathways KDM1B participated on our site, such as Chromatin modifying enzymes, Chromatin organization, HDMs demethylate histones, which may be useful for your reference. Also, other proteins which involved in the same pathway with KDM1B were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Chromatin modifying enzymes
SUZ12A; SAP130; SUDS3; SETD3; HMG20B; MSL1A; TADA3; PRMT7; DR1; EHMT2
Chromatin organization
PBRM1L; TAF6L; MSL1; PHF15; ING4; KDM6B; PAX3A; ZZZ3; JMJD6; RBBP5
HDMs demethylate histones
KDM4C; JMJD6; KDM2AA; KDM5D; PHF2; KDM6B; KDM4B; KDM5BA; KDM4A; KDM3B

Protein Function

KDM1B has several biochemical functions, for example, DNA binding, N-ethylmaleimide reductase activity, NADPH:sulfur oxidoreductase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KDM1B itself. We selected most functions KDM1B had, and list some proteins which have the same functions with KDM1B. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein DDX41; HLFB; TBX6; YY1; VENT; SET; ID2B; PHOX2BB; POU4F1; ZFP13
Function N-ethylmaleimide reductase activity
Related Protein FRRS1; KDM1B; CYBASC3; MOSC2; CYB561A3A; HEPHL1
Function NADPH:sulfur oxidoreductase activity
Related Protein CYBASC3; HEPHL1; MOSC2; MICAL2B; CYB561A3A; MICAL2; FRRS1; KDM1B
Function epoxyqueuosine reductase activity
Related Protein KDM1B; FRRS1; MOSC2; CYBASC3; CYB561A3A; HEPHL1
Function flavin adenine dinucleotide binding
Related Protein MTO1; SDHA; ACOX3; AOX1; FOXRED2; MAOA; XDH; ACADVL; MTHFR; D2HGDH
Function histone demethylase activity (H3-dimethyl-K4 specific)
Related Protein KDM5BB; KDM5B; KDM1A; KDM1B
Function histone demethylase activity (H3-monomethyl-K4 specific)
Related Protein KDM1B
Function NOT histone demethylase activity (H3-trimethyl-K4 specific)
Related Protein KDM1B
Function malolactic enzyme activity
Related Protein CYBASC3; FRRS1; HEPHL1; MOSC2; CYB561A3A; KDM1B
Function metal ion binding
Related Protein ZNFL2A; TRIM105; AGFG1B; NDUFS8; RHEB; MMP30; ABLIM1A; FAM164A; GMEB1; ARSG
Function oxidoreductase activity
Related Protein FAXDC2; GDI1; RTN4IP1; TXNRD3; SCCPDH; CYP3A4; CYP2X10.2; CYP8B2; CYP2P7; CYP2AA3
Function reduced coenzyme F420 dehydrogenase activity
Related Protein HEPHL1; CYBASC3; FRRS1; MOSC2; CYB561A3A; KDM1B
Function sulfur oxygenase reductase activity
Related Protein MOSC2; KDM1B; CYB561A3A; CYBASC3; FRRS1; HEPHL1
Function zinc ion binding
Related Protein RNF138; RBM10; ZCCHC12; LHX1; QPCT; LMO7; RNF149; CA8; ADAMTS5; CPA1

KDM1B Related Articles

Gao, RT; Dong, R; et al. Depletion of histone demethylase KDM2A inhibited cell proliferation of stem cells from apical papilla by de-repression of p15(INK4B) and p27(Kip1). MOLECULAR AND CELLULAR BIOCHEMISTRY 379:115-122(2013).