kdm1b
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  • Official Full Name
  • lysine (K)-specific demethylase 1B
  • Background
  • Flavin-dependent histone demethylases, such as KDM1B, regulate histone lysine methylation, an epigenetic mark that regulates gene expression and chromatin function (Karytinos et al., 2009 [PubMed 19407342]).[supplied by OMIM, Oct 2009]
  • Synonyms
  • KDM1B; lysine (K)-specific demethylase 1B; AOF1; LSD2; C6orf193; bA204B7.3; dJ298J15.2; lysine-specific histone demethylase 1B; amine oxidase, flavin containing 1; lysine-specific histone demethylase 2; amine oxidase (flavin containing) domain 1; flavin-containing amine oxidase domain-containing protein 1;
Cat.#:AOF1-642HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human AOF1 protein, GST-tagged
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Cat.#:KDM1B-8586MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse KDM1B Protein
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Involved Pathway

KDM1B involved in several pathways and played different roles in them. We selected most pathways KDM1B participated on our site, such as Chromatin modifying enzymes, Chromatin organization, HDMs demethylate histones, which may be useful for your reference. Also, other proteins which involved in the same pathway with KDM1B were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Chromatin modifying enzymes
C20orf20; SMARCD3B; PRMT6; GATAD2B; SMARCA4; CHD4; KAT7A; MEAF6; KDM1B; RUVBL2
Chromatin organization
DNMT3A; PADI3; MBD3A; ELP4; SMARCD3; USP22; EHMT2; PBRM1L; MBD3B; SAP30
HDMs demethylate histones
KDM4D; JHDM1D; KDM4B; KDM3B; KDM4A; KDM5BA; PHF2; JMJD6; KDM1A; KDM6B

Protein Function

KDM1B has several biochemical functions, for example, DNA binding, N-ethylmaleimide reductase activity, NADPH:sulfur oxidoreductase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KDM1B itself. We selected most functions KDM1B had, and list some proteins which have the same functions with KDM1B. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein NUSAP1; YBX2; ZFP488; HIST1H2BA; CENPC1; POT1A; HIVEP3; PROX2; ZNF707; NEUROD6
Function N-ethylmaleimide reductase activity
Related Protein FRRS1; CYB561A3A; MOSC2; KDM1B; CYBASC3; HEPHL1
Function NADPH:sulfur oxidoreductase activity
Related Protein HEPHL1; KDM1B; CYBASC3; MICAL2B; CYB561A3A; FRRS1; MICAL2; MOSC2
Function epoxyqueuosine reductase activity
Related Protein FRRS1; CYB561A3A; KDM1B; HEPHL1; CYBASC3; MOSC2
Function flavin adenine dinucleotide binding
Related Protein PPOX; GCDHB; NOS1; DMGDH; NOX4; AOX1; ACADSB; ACOX2; AIFM4; ETFDH
Function histone demethylase activity (H3-dimethyl-K4 specific)
Related Protein KDM1A; KDM1B; KDM5BB; KDM5B
Function histone demethylase activity (H3-monomethyl-K4 specific)
Related Protein KDM1B
Function NOT histone demethylase activity (H3-trimethyl-K4 specific)
Related Protein KDM1B
Function malolactic enzyme activity
Related Protein CYB561A3A; HEPHL1; CYBASC3; FRRS1; MOSC2; KDM1B
Function metal ion binding
Related Protein ZNF543; CHORDC1B; PHF2; ZNF473; EGR3; ZDHHC1; RARAB; Itga10&Itgb1; KLF2A; GTF3AB
Function oxidoreductase activity
Related Protein AIFM4; GPX4B; CYP2Y3; CYP2AA3; LEPREL1; CYP2AA12; PYROXD2; CYP8B1; YWHAE1; GLUD1A
Function reduced coenzyme F420 dehydrogenase activity
Related Protein CYB561A3A; KDM1B; MOSC2; CYBASC3; HEPHL1; FRRS1
Function sulfur oxygenase reductase activity
Related Protein HEPHL1; CYBASC3; CYB561A3A; FRRS1; KDM1B; MOSC2
Function zinc ion binding
Related Protein MMP23BB; MSL2B; DPF2L; ADAMTS4; CD4; RNF168; HIF1AN; ZSWIM3; ADAMTS10; OAS1A

KDM1B Related Articles

Gao, RT; Dong, R; et al. Depletion of histone demethylase KDM2A inhibited cell proliferation of stem cells from apical papilla by de-repression of p15(INK4B) and p27(Kip1). MOLECULAR AND CELLULAR BIOCHEMISTRY 379:115-122(2013).