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KDM1B

Official Full Name

lysine (K)-specific demethylase 1B
Overview

Flavin-dependent histone demethylases, such as KDM1B, regulate histone lysine methylation, an epigenetic mark that regulates gene expression and chromatin function (Karytinos et al., 2009 [PubMed 19407342]).[supplied by OMIM, Oct 2009]
Synonyms

KDM1B; lysine (K)-specific demethylase 1B; AOF1; LSD2; C6orf193; bA204B7.3; dJ298J15.2; lysine-specific histone demethylase 1B; amine oxidase, flavin containing 1; lysine-specific histone demethylase 2; amine oxidase (flavin containing) domain 1; flavin-containing amine oxidase domain-containing protein 1;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	AOF1-642H	Recombinant Human AOF1 protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	KDM1B-1427HF	Recombinant Full Length Human KDM1B Protein, GST-tagged	In Vitro Cell Free System	GST	619 amino acids	Inquiry
Mouse	KDM1B-8586M	Recombinant Mouse KDM1B Protein	Mammalian Cell	His		Inquiry
Mouse	KDM1B-4776M	Recombinant Mouse KDM1B Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	KDM1B-4776M-B	Recombinant Mouse KDM1B Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
KDM1B Related Articles

KDM1B involved in several pathways and played different roles in them. We selected most pathways KDM1B participated on our site, such as Chromatin modifying enzymes, Chromatin organization, HDMs demethylate histones, which may be useful for your reference. Also, other proteins which involved in the same pathway with KDM1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Chromatin modifying enzymes	C17orf81;SMARCC1;VPS72;KDM5D;SMARCA4;ING4;SMARCB1B;BRPF3;PAX3A
Chromatin organization	COPRS;EHMT2;PHF2;PBRM1L;GATAD2AB;ING5;ASH2L;PADI3;SMARCD1
HDMs demethylate histones	ARID5B;KDM2B;KDM3B;KDM6B;KDM7AB;KDM2A;KDM5A;KDM5D;KDM2AA

KDM1B has several biochemical functions, for example, DNA binding, N-ethylmaleimide reductase activity, NADPH:sulfur oxidoreductase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KDM1B itself. We selected most functions KDM1B had, and list some proteins which have the same functions with KDM1B. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	HLFB;VED;HIST1H4H;EF1;HOXC13;RNF4;ERCC2;KLF3;ZNF146
N-ethylmaleimide reductase activity	KDM1B;CYBASC3;MOSC2;FRRS1;HEPHL1;CYB561A3A
NADPH:sulfur oxidoreductase activity	FRRS1;HEPHL1;CYBASC3;MICAL2B;KDM1B;MOSC2;MICAL2;CYB561A3A
epoxyqueuosine reductase activity	CYBASC3;HEPHL1;CYB561A3A;FRRS1;KDM1B;MOSC2
flavin adenine dinucleotide binding	AOX3L1;DLD;GSR;ETFDH;MTRR;POR;NOS3;CRY-DASH;MAOA
histone demethylase activity (H3-dimethyl-K4 specific)	KDM5B;KDM1B;KDM5BB;KDM1A
histone demethylase activity (H3-monomethyl-K4 specific)
NOT histone demethylase activity (H3-trimethyl-K4 specific)
malolactic enzyme activity	MOSC2;HEPHL1;KDM1B;FRRS1;CYB561A3A;CYBASC3
metal ion binding	KLF11B;ITGB1BP3;STAC;PVALB8;NGLY1;PPARAB;THAP6;CYP1C1;PPM1LB
oxidoreductase activity	CYP2X7;ADI1;FLJ13639;DLDH;YWHAE1;CYP2AA6;CYP3A41B;CYP2E1;CRYM
reduced coenzyme F420 dehydrogenase activity	KDM1B;HEPHL1;FRRS1;MOSC2;CYB561A3A;CYBASC3
sulfur oxygenase reductase activity	HEPHL1;MOSC2;CYB561A3A;FRRS1;CYBASC3;KDM1B
zinc ion binding	ANPEPA;MAN2B2;ARIH1;ANKIB1A;ZDHHC17;PHF8;PHF23A;ADAM25;RNF213

KDM1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KDM1B here. Most of them are supplied by our site. Hope this information will be useful for your research of KDM1B.

Gao, RT; Dong, R; et al. Depletion of histone demethylase KDM2A inhibited cell proliferation of stem cells from apical papilla by de-repression of p15(INK4B) and p27(Kip1). MOLECULAR AND CELLULAR BIOCHEMISTRY 379:115-122(2013).