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KDM5C

Official Full Name

lysine (K)-specific demethylase 5C
Overview

This gene is a member of the SMCY homolog family and encodes a protein with one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers. The DNA-binding motifs suggest this protein is involved in the regulation of transcription and chromatin remodeling. Mutations in this gene have been associated with X-linked mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Synonyms

KDM5C; lysine (K)-specific demethylase 5C; MRXJ; SMCX; MRX13; MRXSJ; XE169; MRXSCJ; JARID1C; DXS1272E; lysine-specific demethylase 5C; protein SmcX; selected cDNA on X; Smcy homolog, X-linked; Smcx homolog, X chromosome; histone demethylase JARID1C; mental retardation, X-linked 13; JmjC domain-containing protein SMCX; Jumonji/ARID domain-containing protein 1C; Jumonji, AT rich interactive domain 1C (RBP2-like);

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rhesus Macaque
Zebrafish

Source

HEK293
Mammalian Cell
Sf9 Insect Cell

Tag

Flag
GST
His
His (Fc)
Avi

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	KDM5C-45H	Active Recombinant Human KDM5C, FLAG-tagged	Sf9 Insect Cell	Flag		Inquiry
Human	KDM5C-7032H	Recombinant Human KDM5C, GST-tagged	Sf9 Insect Cell	GST	1-671 aa	Inquiry
Human	KDM5C-1604H	Recombinant Human Lysine (K)-Specific Demethylase 5C, GST-tagged	Sf9 Insect Cell	GST		Inquiry
Mouse	KDM5C-8596M	Recombinant Mouse KDM5C Protein	Mammalian Cell	His		Inquiry
Mouse	KDM5C-4784M-B	Recombinant Mouse KDM5C Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	KDM5C-4784M	Recombinant Mouse KDM5C Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	KDM5C-2383R	Recombinant Rhesus monkey KDM5C Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	KDM5C-2204R	Recombinant Rhesus Macaque KDM5C Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	KDM5C-2204R-B	Recombinant Rhesus Macaque KDM5C Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	KDM5C-6642Z	Recombinant Zebrafish KDM5C	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

KDM5C involved in several pathways and played different roles in them. We selected most pathways KDM5C participated on our site, such as Chromatin modifying enzymes, Chromatin organization, HDMs demethylate histones, which may be useful for your reference. Also, other proteins which involved in the same pathway with KDM5C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Chromatin modifying enzymes	EPC1;ZZZ3;SUZ12;ARID5B;SMYD3;PHF21A;COPRS;HIST2H3C;KDM5BB
Chromatin organization	DNMT3A;KAT7;EP400;TAF6L;SMARCC1B;SMYD2;BRMS1;PADI4;ARID1A
HDMs demethylate histones	KDM5C;KDM5B;KDM5BB;KDM4D;KDM3A;KDM1A;KDM7AB;KDM6AL;KDM4B

KDM5C has several biochemical functions, for example, DNA binding, histone demethylase activity (H3-K4 specific), oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors. Some of the functions are cooperated with other proteins, some of the functions could acted by KDM5C itself. We selected most functions KDM5C had, and list some proteins which have the same functions with KDM5C. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	ZBED5;POLR3A;DBX1B;WRN;POLE4;CRSP7;EGR4;KDM2BA;ZNF134
histone demethylase activity (H3-K4 specific)	C14orf169;KDM5D;KDM1A;KDM5C;KDM5B
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	EGLN1;JHDM1D;KDM5B;KDM5D;HIF1AN;ALKBH5;ALKBH8;P4HTM;C14orf169
zinc ion binding	BBOX1;RNF144B;SHRPRBCK1R;ZACN;CHD4;GRIN2A;BRF1A;RXRB;CA8

KDM5C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KDM5C here. Most of them are supplied by our site. Hope this information will be useful for your research of KDM5C.

h31_bovin; zipA; ptsN1; CSNK2A1; XPO1; E2F6; TOX4; VPS41; MAX; CSNK2B; SET; MGA; ZNF687; ZNF592; CENPK; TSPYL2; SLC25A22; ZNF532; MBD2; ZMYND8