KDM6B
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Official Full Name
lysine (K)-specific demethylase 6B
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Overview
Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation. -
Synonyms
KDM6B; lysine (K)-specific demethylase 6B; JMJD3; lysine-specific demethylase 6B; lysine demethylase 6B; jmjC domain-containing protein 3; jumonji domain-containing protein 3; jumonji domain containing 3, histone lysine demethylase;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Human
- Mouse
- E. coli
- HEK293
- Insect Cell
- Mammalian Cell
- Flag
- His
- His (Fc)
- Avi
- No tag
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | KDM6B-562H | Active Recombinant Human KDM6B, Flag-tagged | Insect Cell | Flag | ||
Human | KDM6B-1066H | Recombinant Human KDM6B | Mammalian Cell | His | ||
Human | KDM6B-0525H | Recombinant Human KDM6B Protein (D1141-L1636), Tag Free | Insect Cell | No tag | D1141-L1636 | |
Human | KDM6B-3201H | Recombinant Human KDM6B Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Human | KDM6B-0526H | Recombinant Human KDM6B Protein (D1141-L1636), His tagged | Insect Cell | His | D1141-L1636 | |
Human | KDM6B-3201H-B | Recombinant Human KDM6B Protein Pre-coupled Magnetic Beads | HEK293 | |||
Human | KDM6B-120H | Recombinant Human KDM6B(1141-1641) Protein | E. coli | 1141-1641 aa | ||
Mouse | KDM6B-8599M | Recombinant Mouse KDM6B Protein | Mammalian Cell | His | ||
Mouse | KDM6B-4786M | Recombinant Mouse KDM6B Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | KDM6B-4786M-B | Recombinant Mouse KDM6B Protein Pre-coupled Magnetic Beads | HEK293 |
- Involved Pathway
- Protein Function
- Interacting Protein
- KDM6B Related Articles
- KDM6B Related Research Area
KDM6B involved in several pathways and played different roles in them. We selected most pathways KDM6B participated on our site, such as Cellular Senescence, Cellular responses to stress, Chromatin modifying enzymes, which may be useful for your reference. Also, other proteins which involved in the same pathway with KDM6B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Cellular Senescence | TINF2;CBX8A;RNF2;HIST1H1D;SUZ12B;EHMT2;CDKN2D;H3F3B.1;RBBP4 |
Cellular responses to stress | TERF1;TERF2;BAG5;ST13;CEBPB;CBX6;WIPI2;RNF2;LC3 |
Chromatin modifying enzymes | KDM1B;PRDM16;BRPF1;MBD3B;SMARCD1;PADI3;MSL1;BRD8;KANSL2 |
Chromatin organization | VPS72;PHF21A;MSL2A;ING5A;RUVBL2;KDM5B;GATAD2A;KDM4D;JHDM1D |
HDMs demethylate histones | JHDM1D;KDM1B;KDM3B;KDM5C;KDM7AB;KDM5D;KDM5B;ARID5B;KDM1A |
Oxidative Stress Induced Senescence | SCMH1;PHC2;CBX4;SUZ12B;CBX8A;SUZ12A;RNF2;EED;PHC1 |
KDM6B has several biochemical functions, for example, beta-catenin binding, chromatin binding, dioxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KDM6B itself. We selected most functions KDM6B had, and list some proteins which have the same functions with KDM6B. You can find most of the proteins on our site.
Function | Related Protein |
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beta-catenin binding | PTPRJ;CARM1;KDM6B;PTPRK;CDH2;CALCOCO1;DACT2;PSEN1;CDH24 |
chromatin binding | NFIA;HMGXB4;RBMX;HMGB1;PARP1;EGFR;NCAPD3;TOX2;SALL1 |
dioxygenase activity | BCO2L;KDM6A;ASPHD1;JMJD5;ALOX5B.2;LEPREL1;BCO1;OGFOD2;ALOX12E |
histone demethylase activity (H3-K27 specific) | PHF8;JHDM1D;KDM6BB;KDM6B;KDM7AB;KDM6A |
metal ion binding | RREB1;SCRT1A;TRIM43C;RBM4.2;HE1B;CRYAA;ZNF277;GALNT4;TGM4 |
protein binding | CIB3;ADAMTSL5;RBM44;TRIM32;MYLIPA;IFNAR1;SOX7;AGBL1;DNALI1 |
sequence-specific DNA binding | FOXF2A;SALL3;DMBX1B;HOXD12A;FOXE3;FOXJ1A;DBX1B;POU1F1;FOXC1 |
KDM6B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KDM6B here. Most of them are supplied by our site. Hope this information will be useful for your research of KDM6B.
ESR1; TK1; CSNK2B; dacA; y2781_yerpe; Cbx1
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