Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

KDM6B

  • Official Full Name

    lysine (K)-specific demethylase 6B

  • Overview

    Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation.
  • Synonyms

    KDM6B; lysine (K)-specific demethylase 6B; JMJD3; lysine-specific demethylase 6B; lysine demethylase 6B; jmjC domain-containing protein 3; jumonji domain-containing protein 3; jumonji domain containing 3, histone lysine demethylase;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Human
  • Mouse
  • E. coli
  • HEK293
  • Insect Cell
  • Mammalian Cell
  • Flag
  • His
  • His (Fc)
  • Avi
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human KDM6B-562H Active Recombinant Human KDM6B, Flag-tagged Insect Cell Flag
Human KDM6B-1066H Recombinant Human KDM6B Mammalian Cell His
Human KDM6B-0525H Recombinant Human KDM6B Protein (D1141-L1636), Tag Free Insect Cell No tag D1141-L1636
Human KDM6B-3201H Recombinant Human KDM6B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human KDM6B-0526H Recombinant Human KDM6B Protein (D1141-L1636), His tagged Insect Cell His D1141-L1636
Human KDM6B-3201H-B Recombinant Human KDM6B Protein Pre-coupled Magnetic Beads HEK293
Human KDM6B-120H Recombinant Human KDM6B(1141-1641) Protein E. coli 1141-1641 aa
Mouse KDM6B-8599M Recombinant Mouse KDM6B Protein Mammalian Cell His
Mouse KDM6B-4786M Recombinant Mouse KDM6B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse KDM6B-4786M-B Recombinant Mouse KDM6B Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • KDM6B Related Articles
  • KDM6B Related Research Area

KDM6B involved in several pathways and played different roles in them. We selected most pathways KDM6B participated on our site, such as Cellular Senescence, Cellular responses to stress, Chromatin modifying enzymes, which may be useful for your reference. Also, other proteins which involved in the same pathway with KDM6B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cellular SenescenceTINF2;CBX8A;RNF2;HIST1H1D;SUZ12B;EHMT2;CDKN2D;H3F3B.1;RBBP4
Cellular responses to stressTERF1;TERF2;BAG5;ST13;CEBPB;CBX6;WIPI2;RNF2;LC3
Chromatin modifying enzymesKDM1B;PRDM16;BRPF1;MBD3B;SMARCD1;PADI3;MSL1;BRD8;KANSL2
Chromatin organizationVPS72;PHF21A;MSL2A;ING5A;RUVBL2;KDM5B;GATAD2A;KDM4D;JHDM1D
HDMs demethylate histonesJHDM1D;KDM1B;KDM3B;KDM5C;KDM7AB;KDM5D;KDM5B;ARID5B;KDM1A
Oxidative Stress Induced SenescenceSCMH1;PHC2;CBX4;SUZ12B;CBX8A;SUZ12A;RNF2;EED;PHC1

KDM6B has several biochemical functions, for example, beta-catenin binding, chromatin binding, dioxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KDM6B itself. We selected most functions KDM6B had, and list some proteins which have the same functions with KDM6B. You can find most of the proteins on our site.

Function Related Protein
beta-catenin bindingPTPRJ;CARM1;KDM6B;PTPRK;CDH2;CALCOCO1;DACT2;PSEN1;CDH24
chromatin bindingNFIA;HMGXB4;RBMX;HMGB1;PARP1;EGFR;NCAPD3;TOX2;SALL1
dioxygenase activityBCO2L;KDM6A;ASPHD1;JMJD5;ALOX5B.2;LEPREL1;BCO1;OGFOD2;ALOX12E
histone demethylase activity (H3-K27 specific)PHF8;JHDM1D;KDM6BB;KDM6B;KDM7AB;KDM6A
metal ion bindingRREB1;SCRT1A;TRIM43C;RBM4.2;HE1B;CRYAA;ZNF277;GALNT4;TGM4
protein bindingCIB3;ADAMTSL5;RBM44;TRIM32;MYLIPA;IFNAR1;SOX7;AGBL1;DNALI1
sequence-specific DNA bindingFOXF2A;SALL3;DMBX1B;HOXD12A;FOXE3;FOXJ1A;DBX1B;POU1F1;FOXC1

KDM6B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KDM6B here. Most of them are supplied by our site. Hope this information will be useful for your research of KDM6B.

ESR1; TK1; CSNK2B; dacA; y2781_yerpe; Cbx1

Guo, XQ; Tian, ZT; et al. Regulation of histone demethylase KDM6B by hypoxia-inducible factor-2 alpha. ACTA BIOCHIMICA ET BIOPHYSICA SINICA 47:106-113(2015).
Zhang, PP; Wang, XL; et al. DNA Methylation-mediated Repression of miR-941 Enhances Lysine (K)-specific Demethylase 6B Expression in Hepatoma Cells. JOURNAL OF BIOLOGICAL CHEMISTRY 289:24724-24735(2014).
  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All KDM6B Products

Required fields are marked with *

My Review for All KDM6B Products

Required fields are marked with *

logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends