KDSR
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Official Full Name
3-ketodihydrosphingosine reductase
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Overview
The protein encoded by this gene catalyzes the reduction of 3-ketodihydrosphingosine to dihydrosphingosine. The putative active site residues of the encoded protein are found on the cytosolic side of the endoplasmic reticulum membrane. A chromosomal rearrangement involving this gene is a cause of follicular lymphoma, also known as type II chronic lymphatic leukemia. The mutation of a conserved residue in the bovine ortholog causes spinal muscular atrophy. -
Synonyms
KDSR; 3-ketodihydrosphingosine reductase; follicular lymphoma variant translocation 1 , FVT1; 3 dehydrosphinganine reductase; DHSR; SDR35C1; short chain dehydrogenase/reductase family 35C; member 1; FLJ92680; 3 ketodihydrosphingosine reductase; 3-dehydrosphinganine reductase; FLJ36555; Follicular lymphoma variant translocation 1; Follicular variant translocation protein 1; FVT 1; FVT-1; KDS reductase; KDSR_HUMAN; Short chain dehydrogenase/reductase family 35C member 1; OTTHUMP00000163681; short chain dehydrogenase/reductase family 35C, member 1; FVT1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bos taurus (Bovine)
- Chicken
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Rhesus Macaque
- Zebrafish
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- His|GST
- Myc
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
KDSR involved in several pathways and played different roles in them. We selected most pathways KDSR participated on our site, such as Sphingolipid metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with KDSR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Sphingolipid metabolism | ARSE;LASS1;OSBP;GLTPA;GALCA;SGPP1;SPTLC2B;NEU3.4;ARSA |
| Metabolic pathways | Amy1;AK7B;PIK3C2G;POLR3G;ST20-MTHFS;TCIRG1;HLCS;SUCLA2;UGT1AB |
KDSR has several biochemical functions, for example, 3-dehydrosphinganine reductase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KDSR itself. We selected most functions KDSR had, and list some proteins which have the same functions with KDSR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 3-dehydrosphinganine reductase activity |
KDSR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KDSR here. Most of them are supplied by our site. Hope this information will be useful for your research of KDSR.
MAPK6; Ercc6l
- Q&As
- Reviews
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