keap1
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  • Official Full Name
  • kelch-like ECH-associated protein 1
  • Background
  • The nuclear factor-like 2 (NRF2) transcriptional activator binds antioxidant response elements (ARE) of target gene promoter regions to regulate expression of oxidative stress response genes. Under basal conditions, the NRF2 inhibitor INrf2 (also called K
  • Synonyms
  • KEAP1; kelch-like ECH-associated protein 1; INrf2; KIAA0132; KLHL19; MGC1114; MGC4407; MGC9454; MGC10630; MGC20887; kelch-like protein 19; cytosolic inhibitor of Nrf2
Cat.#:KEAP1-2185HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human KEAP1 Protein (1-624 aa), His-tagged
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Cat.#:KEAP1-188HTag:FC/His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human KEAP1, His-GST tagged
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Cat.#:KEAP1-547HTag:His, GST & AVI
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human KEAP1, His, GST & AVI tagged
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Cat.#:KEAP1-550HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human KEAP1, Gly & Pro tagged
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Cat.#:KEAP1-652HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human KEAP1 protein, MYC/DDK-tagged
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Cat.#:KEAP1-653HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human KEAP1 protein, GST-tagged
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Cat.#:KEAP1-776HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human KEAP1
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Cat.#:KEAP1-829HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human KEAP1 protein, His-tagged
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Cat.#:Keap1-1875MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Keap1 protein, His & T7-tagged
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Cat.#:KEAP1-8602MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse KEAP1 Protein
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Cat.#:KEAP1-3240RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat KEAP1 Protein
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Cat.#:KEAP1-001HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human KEAP1 cell lysate
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Involved Pathway

KEAP1 involved in several pathways and played different roles in them. We selected most pathways KEAP1 participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with KEAP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ubiquitin mediated proteolysis
ITCHA; CDC34; UBE2IA; MGRN1A; UBA6; MGRN1B; UBE2QL1; PRPF19; BIRC3; SMURF1

Protein Function

KEAP1 has several biochemical functions, for example, protein binding, transcription factor binding, contributes_to ubiquitin-protein transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KEAP1 itself. We selected most functions KEAP1 had, and list some proteins which have the same functions with KEAP1. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein GATA3; ZBTB24; SCN11A; ZFPL1; CDKN2B; UBXN11; COL1A1; KRTAP9-4; ZNF346; TRIM74
Function transcription factor binding
Related Protein DDIT3; E2F5; HDAC4; HDAC9; NAAA; INSIG2; MSX2; KAT6B; YWHAZ; PIAS1
Function contributes_to ubiquitin-protein transferase activity
Related Protein UBE2C; BARD1; TCEB1; BTRC; KLHL12; KLHL38; BACH1; KLHL29; KEAP1A; KLHL20

Interacting Protein

KEAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KEAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of KEAP1.
SQSTM1; ETF1; NFE2L2

KEAP1 Related Articles

Cui, GZ; Luk, SCW; et al. Cytoprotection of Baicalein Against Oxidative Stress-induced Cardiomyocytes Injury Through the Nrf2/Keap1 Pathway. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY 65:39-46(2015).
Murakami, A; et al. Mechanisms Underlying Physiological Functions of Food Factors via Non-specific Interactions with Biological Proteins. YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN 135:47-55(2015).