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KLB

  • Official Full Name

    klotho beta

  • Synonyms

    KLB; klotho beta; beta-klotho; betaKlotho; klotho beta like; klotho beta-like protein; BKL; MGC142213;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Monkey
  • Mouse
  • Rat
  • Rhesus macaque
  • E.coli
  • HEK293
  • Mammalian Cell
  • Mammalian cells
  • NS0
  • C
  • 6×His
  • Fc
  • His
  • His (Fc)
  • Avi
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human KLB-538H Active Recombinant Human KLB, His-tagged Mammalian cells His
Human KLB-5671H Active Recombinant Human Klotho Beta, His-tagged Mammalian cells His
Human KLB-537H Recombinant Human KLB, Fc-tagged HEK293 Fc
Human KLB-1560H Recombinant Human KLB protein, His-tagged E.coli His Val517~Ser636 (Accession # Q86Z14)
Human KLB-539H Recombinant Human KLB protein, His-tagged HEK293 His Met30-Thr983
Human KLB-3221H Recombinant Human KLB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human KLB-3221H-B Recombinant Human KLB Protein Pre-coupled Magnetic Beads HEK293
Human KLB-3693H Recombinant Human KLB Protein (Gly52-Phe508), N-His tagged E.coli N-His Gly52-Phe508
Human KLB-3694H Recombinant Human KLB Protein (Lys2-Pro995), N-His tagged E.coli N-His Lys2-Pro995
Human KLB-3695H Recombinant Human KLB Protein (Lys2-Pro996), N-His tagged E.coli N-His Lys2-Pro996
Mouse Klb-778M Active Recombinant Mouse Klb Protein, His-tagged Mammalian cells His Phe53-Leu995
Mouse KLB-8668M Recombinant Mouse KLB Protein Mammalian Cell His
Mouse Klb-1561M Recombinant Mouse Klb protein, His-tagged E.coli His Ser380~Phe506 (Accession # Q99N32)
Mouse Klb-4830M-B Recombinant Mouse Klb Protein Pre-coupled Magnetic Beads HEK293
Mouse Klb-1715M Recombinant Mouse Klb Protein, His-tagged E.coli N-His Met515-Leu965
Mouse KLB-0319M Active Recombinant Mouse KLB protein, His-tagged HEK293 His Phe53-Leu995
Mouse Klb-4830M Recombinant Mouse Klb Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat KLB-0318R Recombinant Rat KLB protein, His-tagged HEK293 His Phe53-Pro994
Monkey Klb-34M Active Recombinant Cynomolgus Monkey Klb Protein (Phe53-Leu997), C-6×His tagged NS0 C-6×His Phe53-Leu997
Rhesus macaque KLB-1291R Active Recombinant Rhesus macaque KLB protein, His-tagged HEK293 His Phe53-Leu997
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • KLB Related Articles

KLB involved in several pathways and played different roles in them. We selected most pathways KLB participated on our site, such as ARMS-mediated activation, Adaptive Immune System, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with KLB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ARMS-mediated activationPEA15A;FRS2B;SPNA2;CSF2;KBTBD7;PSMD10;DAB2IPB;PSMD9;SPRED2
Adaptive Immune SystemOSCAR;UBE2J2;KIF4;AP2B1;FRS2;SPSB4;UBE2L6;LILRB4;IGKC
Axon guidanceARHGEF28;GFRA2;EPHB3;PLXNA1;ABL1;HRAS;RHOC;ARPC3;NTN1A
Constitutive Signaling by Aberrant PI3K in CancerNRG3;NRG4;FRS2;HBEGF;EGF;TRAT1;KLB
Cytokine Signaling in Immune systemEGR1;EDAR;SPRED2;SPNA2;OSTN;WDR83;SOCS3A;TRIM68;BST2
DAP12 interactionsCLEC5A;SPTB;RASGEF1A;FRS2B;PEA15A;MARK3;AHCYL1;FGF8B;KIR2DS2
DAP12 signalingIL17RD;FRS3;AGO2;NRG3;CSF2RA;GRAP2A;CNKSR1;DUSP2;THEM4
Developmental BiologyDCX;DPYSL3;MEF2B;CDK19;PSPN;SALL4;FRS3;KALRNB;RND1L

KLB has several biochemical functions, for example, fibroblast growth factor binding, fibroblast growth factor receptor binding, hydrolase activity, hydrolyzing O-glycosyl compounds. Some of the functions are cooperated with other proteins, some of the functions could acted by KLB itself. We selected most functions KLB had, and list some proteins which have the same functions with KLB. You can find most of the proteins on our site.

Function Related Protein
fibroblast growth factor bindingFGFBP1;FGFR1A;Api5;FGFR3;GPC1;S100A13;FIBP;CEP57;GLG1B
fibroblast growth factor receptor bindingFGF10A;FGF8A;FGF20B;FGF9;FGF4;FGF2;FGF6A;FGF3;FGF20A
hydrolase activity, hydrolyzing O-glycosyl compoundsGBE1;ABHD10;CHIA.1;CHIA.2;KLB;LCTL;GNE;LCTLA;CHIA.4
protein bindingCHMP4A;ZNF16;MTSS1;SYNDIG1;PNKD;TET3;DFFA;TUBA1B;CIDEB

KLB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KLB here. Most of them are supplied by our site. Hope this information will be useful for your research of KLB.

FGFR1; FGF21; midostaurin

Almilaji, A; Pakladok, T; et al. Upregulation of KCNQ1/KCNE1 K+ channels by Klotho. CHANNELS 8:-(2014).
Zhang, J; Li, Y; et al. Fibroblast growth factor 21, the endocrine FGF pathway and novel treatments for metabolic syndrome. DRUG DISCOVERY TODAY 19:579-589(2014).
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