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KLHDC3

Official Full Name

kelch domain containing 3
Overview

The protein encoded by this gene contains six repeated kelch motifs that are structurally similar to recombination activating gene 2 (RAG2), a protein involved in the activation of the V(D)J recombination. In mouse, this gene is found to express specifically in testis. Its expression in pachytene spermatocytes is localized to cytoplasma and meiotic chromatin, which suggests that this gene may be involved in meiotic recombination. Alternatively spliced transcript variants have been found.
Synonyms

KLHDC3; kelch domain containing 3; kelch domain-containing protein 3; dJ20C7.3; hPeas; PEAS; KLDC3_HUMAN; Protein Peas; RP1-20C7.3; Testis intracellular mediator protein;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat
Zebrafish

Source

E.coli
HEK293
HEK293T
Insect Cell
Mammalian Cell

Tag

His
His (Fc)
Avi
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	KLHDC3-405H	Recombinant Human KLHDC3 Protein, His&Myc-tagged	E.coli	His&Myc	1-382aa	$319 / 25ug
Human	KLHDC3-4921HCL	Recombinant Human KLHDC3 293 Cell Lysate	HEK293	N/A		Inquiry
Human	KLHDC3-2336H	Recombinant Human KLHDC3 protein, His&Myc-tagged	Insect Cell	His&Myc	1-382aa	Inquiry
Mouse	KLHDC3-8693M	Recombinant Mouse KLHDC3 Protein	Mammalian Cell	His		Inquiry
Mouse	Klhdc3-3705M	Recombinant Mouse Klhdc3 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Mouse	KLHDC3-4845M-B	Recombinant Mouse KLHDC3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	KLHDC3-4845M	Recombinant Mouse KLHDC3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	KLHDC3-3275R	Recombinant Rat KLHDC3 Protein	Mammalian Cell	His		Inquiry
Rat	KLHDC3-2931R	Recombinant Rat KLHDC3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	KLHDC3-2931R-B	Recombinant Rat KLHDC3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	KLHDC3-12462Z	Recombinant Zebrafish KLHDC3	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
KLHDC3 Related Articles

KLHDC3 involved in several pathways and played different roles in them. We selected most pathways KLHDC3 participated on our site, such as IRE1alpha activates chaperones, Metabolism of proteins, Unfolded Protein Response (UPR), which may be useful for your reference. Also, other proteins which involved in the same pathway with KLHDC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
IRE1alpha activates chaperones	CXXC1;PREB;FKBP14;CTDSP2;DNAJB9;ASNA1;TPP1;ADD1;SEC61B
Metabolism of proteins	GNE;B3GNT3;CPN1;ZDHHC2;TBCC;IGF2B;MGAT4B;PFDN4;MUC5AC
Unfolded Protein Response (UPR)	FKBP14;YY2;CXXC1;PDIA6;SERP1;HDGF;DDX11;SEC63;HYOU1
XBP1(S) activates chaperone genes	C19orf10;KLHDC3;HDGF;HYOU1;DDX11;DNAJB9;SEC63;ASNA1;FKBP14

KLHDC3 has several biochemical functions, for example, chromatin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KLHDC3 itself. We selected most functions KLHDC3 had, and list some proteins which have the same functions with KLHDC3. You can find most of the proteins on our site.

Function	Related Protein
chromatin binding	KIAA0101;GATA2A;CHAF1A;SP140L;SMARCD3;ORC1L;REL;HMG20A;NFKB1
protein binding	NRBF2;AMOTL2A;C12orf5;CLCF1;SUPT6H;TSSK6;ARHGEF7;LAX1;ACVR1L

KLHDC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KLHDC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of KLHDC3.

DLG3; UBXN7; CSNK1E

Elf, K; Sheuchenko, G; et al. Alterations in muscle proteome of patients diagnosed with amyotrophic lateral sclerosis. JOURNAL OF PROTEOMICS 108:55-64(2014).

Wang, Q; Burles, K; et al. Ectromelia Virus Encodes a BTB/kelch Protein, EVM150, That Inhibits NF-kappa B Signaling. JOURNAL OF VIROLOGY 88:4853-4865(2014).

Ikonomov, OC; Sbrissa, D; et al. Active PIKfyve associates with and promotes the membrane attachment of the late endosome-to-trans-Golgi network transport factor Rab9 effector p40. JOURNAL OF BIOLOGICAL CHEMISTRY 278:50863-50871(2003).