KPNB1
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Official Full Name
karyopherin (importin) beta 1
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Overview
Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013] -
Synonyms
KPNB1; karyopherin (importin) beta 1; IMB1; IPO1; IPOB; Impnb; NTF97; importin subunit beta-1; PTAC97; importin 1; importin 90; importin-90; nuclear factor p97; importin beta-1 subunit; karyopherin subunit beta-1; pore targeting complex 97 kDa subunit;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Sf9 Insect Cell
- Wheat Germ
- DDK
- GST
- His
- His (Fc)
- Avi
- N
- Involved Pathway
- Protein Function
- Interacting Protein
KPNB1 involved in several pathways and played different roles in them. We selected most pathways KPNB1 participated on our site, such as RNA transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with KPNB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RNA transport | EIF3EB;EIF4A1B;GEMIN8;XPO1;THOC4;KPNB1;EIF4G2B;ELAC1;SENP2 |
KPNB1 has several biochemical functions, for example, Ran GTPase binding, enzyme binding, nuclear localization sequence binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KPNB1 itself. We selected most functions KPNB1 had, and list some proteins which have the same functions with KPNB1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| Ran GTPase binding | IPO11;RANBP3;CSE1L;IPO7;IPO5;RANBP2;IPO13;RANGAP1;XPOT |
| enzyme binding | MARCH6;MAT2B;BIRC5;CSF3;TRIO;PCCA;HSPA2;SRC;GOLPH3 |
| nuclear localization sequence binding | KPNA6;RANBP6;KPNA7;IPO5;TNPO1;IPO13;NFKBIA;KPNB1;IPO4 |
| poly(A) RNA binding | U2AF2;RPS17;SSB;HMGB2;ASCC3;PKM;YARS;RPL32;HNRNPK |
| protein binding | CBFB;SUGP1;TBC1D16;TTC35;CTNNBL1;NAA10;VCL;ATP6V1E1;ACAN |
| protein domain specific binding | YWHAH;TWIST2;TWIST1;KPNB1;HIST1H4L;RAN;HIST1H4D;NR0B1;HNRNPM |
| protein transporter activity | CCT6B;XPO5;ITGB1BP1;RAMP3;AP4B1;EIF4ENIF1;IPO7;MLC1;RANGRF |
| zinc ion binding | RNF43;RNF183;FHL3B;ZDHHC19;MMP9;RAG1;ZFML;KDM2A;PHF1 |
KPNB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KPNB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of KPNB1.
KPNA2; L1; NSP1; PLCD1; Mkl1; rev; ERBB2
- Q&As
- Reviews
Q&As (6)
Ask a questionChemicals and phototherapy may inhibit tumor proliferation and metastasis by impairing KPNB1 protein function.
Low expression of KPNB1 protein may be associated with some autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus.
Overexpression of KPNB1 protein may make malignancy proliferation and metastasis more aggressive and associated with poor prognosis.
KPNB1 protein is involved in the entry of viruses into host cells, such as envelope virus, herpes simplex virus, varicella zovirus (VZV), etc.
Some studies have found that KPNB1 has high expression levels in liver cancer cells, which may be related to the malignant transformation of liver cancer.
KPNB1 protein can help transport many tumor-related proteins in tumor cells, such as p53, BRCA1, BRCA2, etc., which in turn affect the transcription and DNA repair processes of cells.
Customer Reviews (3)
Write a reviewIn the case of repeated experiments, the stability of this protein was still very good, indicating its high repeatability and reproducibility.
The strong biological activity of KPNB1, combined with its high purity, provides a reliable experimental basis for the research field.
Beacuse high efficiency and wide storage conditions of proteins make the experimental process more convenient and save a lot of time for scientific research.
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