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Kcnn2

  • Official Full Name

    Kcnn2 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2

  • Synonyms

    KCNN2; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2; small conductance calcium-activated potassium channel protein 2; SKCa 2; small conductance calcium-activated potassium channel subfamily N member 2; SK2; fri; SKCA2; KCa2.2;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • E.coli
  • E.coli expression system
  • HEK293
  • In vitro E. coli expression system
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human KCNN2-2357H Recombinant Human KCNN2 Protein, His-tagged E.coli N-His Lys466-Ser579
Mouse KCNN2-8543M Recombinant Mouse KCNN2 Protein Mammalian Cell His
Mouse KCNN2-4753M Recombinant Mouse KCNN2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse KCNN2-4753M-B Recombinant Mouse KCNN2 Protein Pre-coupled Magnetic Beads HEK293
Rat KCNN2-3219R Recombinant Rat KCNN2 Protein Mammalian Cell His
Rat Kcnn2-048R Recombinant Rat Kcnn2 Full Length Transmembrane protein, His-tagged In vitro E. coli expression system His 1-580aa
Rat KCNN2-2875R Recombinant Rat KCNN2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat KCNN2-2875R-B Recombinant Rat KCNN2 Protein Pre-coupled Magnetic Beads HEK293
Homo sapiens (Human) RFL14368HF Recombinant Full Length Human Small Conductance Calcium-Activated Potassium Channel Protein 2(Kcnn2) Protein, His-Tagged E.coli expression system His Full Length (1-579)
Mus musculus (Mouse) RFL18984MF Recombinant Full Length Mouse Small Conductance Calcium-Activated Potassium Channel Protein 2(Kcnn2) Protein, His-Tagged E.coli expression system His Full Length (1-574)
Rattus norvegicus (Rat) RFL16380RF Recombinant Full Length Rat Small Conductance Calcium-Activated Potassium Channel Protein 2(Kcnn2) Protein, His-Tagged E.coli expression system His Full Length (1-580)
Chicken KCNN2-6361C Recombinant Chicken KCNN2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Kcnn2 Related Articles

Kcnn2 involved in several pathways and played different roles in them. We selected most pathways Kcnn2 participated on our site, such as BDNF signaling pathway, Bile secretion, Ca2+ activated K+ channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with Kcnn2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
BDNF signaling pathwayMAP3K2;FRS3;EIF4E;DPYSL2;GRIP1;EIF4EBP1;CFL1;IGF2BP1;CSNK2A1
Bile secretionSLC27A5;AQP4;FAM84B;SLC22A8;KCNN2;BAAT;ATP1A3;SULT2A1;PRKACG
Ca2+ activated K+ channelsKCNMA1;KCNN1;KCNMB1;KCNN4;KCNN3;KCNN2;KCNN1A;KCNN1B;KCNMB2
Insulin secretionATP1B4;PLCB3;CREB3L3;ATF4;ATP1B1;GNAQ;ATP1B2;RIMS2;PRKCB
Neuronal SystemDLG3;KCNA6A;KCNH1;KCNB1;CACNG2B;LIN7A;KCND3;KCNK1B;KCNH2
Potassium ChannelsKCNB2;KCNJ1A.5;KCNH1B;KCNJ1B;KCNK13B;KCNK4;KCNK1A;KCNS2;KCNA2B
Serotonergic synapseTPH2;CYP2C70;CYP2D26;HTR2C;PLA2G4F;MAP2K1;GNG7;HTR3C;SLC6A4

Kcnn2 has several biochemical functions, for example, alpha-actinin binding, calcium-activated potassium channel activity, calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Kcnn2 itself. We selected most functions Kcnn2 had, and list some proteins which have the same functions with Kcnn2. You can find most of the proteins on our site.

Function Related Protein
alpha-actinin bindingXIRP2;LRRC10;ADORA2A;KCNA5;ALMS1;RARA;MAGI1;DAG1;MYOT
calcium-activated potassium channel activityKCNT1;KCNMB1;KCNMA1;KCNN4;CCT8L2;PKD2L1;KCNMA1A;KCNN1B;KCNMB4
calmodulin bindingKCNH5;RYR2;STRN4;KCNN2;VAMP2;MYO5B;PATE4;PHKG1B;ADCY1
protein domain specific bindingSP100;ATP1A1;GABRR1;TNNI3;HIST1H4J;CALM3;POU2F2;ANGEL1;SHC4
protein homodimerization activityTGFB2;C16orf89;CRYM;IDE;GPD1B;G6PD;GNPTG;LILRB1;KCNH2
small conductance calcium-activated potassium channel activityKCNN1A;KCNN3;KCNN1B;KCNN2;KCNN1

Kcnn2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Kcnn2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Kcnn2.

SRPK2; SRPK1

Kim, JJ; Park, YM; et al. Identification of KCNN2 as a susceptibility locus for coronary artery aneurysms in Kawasaki disease using genome-wide association analysis. JOURNAL OF HUMAN GENETICS 58:521-525(2013).
Chang, SH; Chang, SN; et al. Significant Association of rs13376333 in KCNN3 on Chromosome 1q21 With Atrial Fibrillation in a Taiwanese Population. CIRCULATION JOURNAL 76:184-188(2012).
Li, C; Wang, F; et al. Significant association of SNP rs2106261 in the ZFHX3 gene with atrial fibrillation in a Chinese Han GeneID population. HUMAN GENETICS 129:239-246(2011).
Mauler, F; Hinz, V; et al. Selective intermediate-/small-conductance calcium-activated potassium channel (KCNN4) blockers are potent and effective therapeutics in experimental brain oedema and traumatic brain injury caused by acute subdural haematoma. EUROPEAN JOURNAL OF NEUROSCIENCE 20:1761-1768(2004).
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