kcnn2
Share
  • Official Full Name
  • Kcnn2 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
  • Synonyms
  • KCNN2; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2; small conductance calcium-activated potassium channel protein 2; SKCa 2; small conductance calcium-activated potassium channel subfamily N member 2; SK2; fri; SKCA2; KCa2.2;
Cat.#:KCNN2-8543MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse KCNN2 Protein
+Inquiry
Cat.#:KCNN2-3219RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat KCNN2 Protein
+Inquiry
Cat.#:KCNN2-6361CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken KCNN2
+Inquiry
Cat.#:CSC-RI0108Tag:
Source (Host):Species:Human
Product nameHuman KCNN2 Stable Cell Line-CHO
+Inquiry
Cat.#:CSC-RI0109Tag:
Source (Host):Species:Human
Product nameHuman KCNN2 Stable Cell Line-CHO
+Inquiry

Involved Pathway

Kcnn2 involved in several pathways and played different roles in them. We selected most pathways Kcnn2 participated on our site, such as BDNF signaling pathway, Bile secretion, Ca2+ activated K+ channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with Kcnn2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
BDNF signaling pathway
FRS3; GNB2L1; YBX1; SIRPA; EEF2; FRS2; CDK5; CNR1; CFL1; IGF2BP1
Bile secretion
ATP1B4; CYP7A1; SLC10A2; AQP4; SLCO1B2; SLC9A3; Car2; SLC27A5; ADCY8; ATP1A1
Ca2+ activated K+ channels
KCNN1; KCNMB1; KCNN2; KCNN1B; KCNMB2; KCNN3; KCNN1A; KCNN4; KCNMA1
Insulin secretion
Adcy4; ADCYAP1; FXYD2; KCNMB2; ATP1A4; KCNMA1; SLC2A1; CREB3L2; RAPGEF4; PRKCA
Neuronal System
GJA10; PANX2; KCNH8; KCNH2A; DDX1; PANX1B; KCNA1; KCNK16; KCNA6A; PANX1A
Potassium Channels
KCNK18; KCNJ1; KCNC2; KCNQ2A; KCNH1B; KCNJ1A.5; KCNAB1A; KCNA6; KCNF1; KCNA2
Serotonergic synapse
PLA2G4A; GNB3; SLC18A2; GNG5; MAOA; HTR3A; TPH2; PLCB2; HRAS; CYP2D10

Protein Function

Kcnn2 has several biochemical functions, for example, alpha-actinin binding, calcium-activated potassium channel activity, calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Kcnn2 itself. We selected most functions Kcnn2 had, and list some proteins which have the same functions with Kcnn2. You can find most of the proteins on our site.
Function
Related Protein
Function alpha-actinin binding
Related Protein ADORA2A; MYOT; LRRC10; XIRP2; MAGI1; KCNN2; DAG1; PKD2L1; PPARG; KCNA5
Function calcium-activated potassium channel activity
Related Protein KCNT1; KCNMB1; MTMR6; KCNMB2; KCNN1A; KCNMA1A; HPN; KCNMA1; KCNN2; KCNMB4
Function calmodulin binding
Related Protein MYO1F; GM101; MARCKSA; TRPC2; PHKG1B; TRPV4; SRY; OBSCN; CAMK2G1; MIP
Function protein domain specific binding
Related Protein RAB27A; VPS4A; ARFIP2; FOXH1; PHRF1; HIST1H4D; STRN4; VRK2; ZFP521; YWHABA
Function protein homodimerization activity
Related Protein LGALS6; PPP2R4; LRRFIP1; XPNPEP1; ASMT; NOS1; HMGCS1; DMRT1; SP100; MCL1A
Function small conductance calcium-activated potassium channel activity
Related Protein KCNN2; KCNN1B; KCNN1A; KCNN3; KCNN1

Interacting Protein

Kcnn2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Kcnn2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Kcnn2.
SRPK2; SRPK1

Kcnn2 Related Articles

Kim, JJ; Park, YM; et al. Identification of KCNN2 as a susceptibility locus for coronary artery aneurysms in Kawasaki disease using genome-wide association analysis. JOURNAL OF HUMAN GENETICS 58:521-525(2013).
Chang, SH; Chang, SN; et al. Significant Association of rs13376333 in KCNN3 on Chromosome 1q21 With Atrial Fibrillation in a Taiwanese Population. CIRCULATION JOURNAL 76:184-188(2012).
Li, C; Wang, F; et al. Significant association of SNP rs2106261 in the ZFHX3 gene with atrial fibrillation in a Chinese Han GeneID population. HUMAN GENETICS 129:239-246(2011).
Mauler, F; Hinz, V; et al. Selective intermediate-/small-conductance calcium-activated potassium channel (KCNN4) blockers are potent and effective therapeutics in experimental brain oedema and traumatic brain injury caused by acute subdural haematoma. EUROPEAN JOURNAL OF NEUROSCIENCE 20:1761-1768(2004).