KEAP1
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Official Full Name
kelch-like ECH-associated protein 1
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Overview
The nuclear factor-like 2 (NRF2) transcriptional activator binds antioxidant response elements (ARE) of target gene promoter regions to regulate expression of oxidative stress response genes. Under basal conditions, the NRF2 inhibitor INrf2 (also called K -
Synonyms
KEAP1; kelch-like ECH-associated protein 1; INrf2; KIAA0132; KLHL19; MGC1114; MGC4407; MGC9454; MGC10630; MGC20887; kelch-like protein 19; cytosolic inhibitor of Nrf2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect Cell
- Insect Cells
- Mamanlian cells
- Mammalian Cell
- Wheat Germ
- Yeast
- Fc|His
- Flag
- GST
- His
- His (Fc)
- Avi
- His|T7
- SUMO
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- KEAP1 Related Articles
KEAP1 involved in several pathways and played different roles in them. We selected most pathways KEAP1 participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with KEAP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ubiquitin mediated proteolysis | UBE3C;FANCL;CBL;UBE2D2A;CUL3B;CDC34A;KEAP1;TRIM32;SIAH1A |
KEAP1 has several biochemical functions, for example, protein binding, transcription factor binding, contributes_to ubiquitin-protein transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KEAP1 itself. We selected most functions KEAP1 had, and list some proteins which have the same functions with KEAP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | SNAP29;SF3B3;ECH1;ERCC6;IGFN1;STEAP3;NR4A1;DYNC2LI1;TINAGL1 |
| transcription factor binding | TCF7L2;DOT1L;NEUROD1;ETS1;POU5F1;RBPJ;MAPK1;HEY1;CAMTA2 |
| contributes_to ubiquitin-protein transferase activity | KLHL42;KLHL24A;KBTBD10;KBTBD12;DTL;KEAP1A;KLHL40A;KLHL32;KLHDC8A |
KEAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KEAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of KEAP1.
SQSTM1; ETF1; NFE2L2
- Q&As
- Reviews
Q&As (5)
Ask a questionKEAP1 acts as a sensor for oxidative stress by interacting with NRF2. When cells experience oxidative stress, KEAP1 releases NRF2, allowing it to translocate into the nucleus and initiate the expression of various cytoprotective genes.
Post-translational modifications such as phosphorylation, ubiquitination, and acetylation control the interaction between KEAP1 and NRF2, influencing NRF2's stability and activity.
One challenge is the need for specific targeting without causing adverse effects on normal cell function, as NRF2 has both protective and potentially harmful effects.
Researchers are exploring small molecules that modulate the KEAP1-NRF2 interaction, aiming to enhance NRF2 activation for therapeutic benefit in conditions where oxidative stress plays a significant role.
Yes, there are clinical trials investigating drugs that target the KEAP1-NRF2 pathway in cancer treatment, especially for lung and pancreatic cancers.
Customer Reviews (3)
Write a reviewThis protein demonstrates exceptional performance in ELISA, delivering accurate and reliable results in the detection and quantification of specific antigens.
KEAP1 protein has proven to be instrumental in protein electron microscopy structure analysis.
With KEAP1 protein, researchers can visualize protein complexes and their interactions with remarkable clarity, unraveling important insights into their functional mechanisms.
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