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KNG1

  • Official Full Name

    Kininogen Heavy Chain

  • Overview

    Kininogens are inhibitors of thiol proteases. HMW Kininogen plays an important role in blood coagulation by helping to position optimally pre-Kallikrein and Factor XI next to Factor XII. HMW Kininogen inhibits the Thrombin- and Plasmin-induced aggregation of thrombocytes; the active peptide Bradykinin that is released from HMW Kininogen shows a variety of physiological effects: influence in smooth muscle contraction, induction of hypotension, natriuresis and diuresis and decrease in blood glucose level. It is also a mediator of inflammation and causes increase in vascular permeability, stimulation of nociceptors release of other mediators of inflammation (e.g. Prostaglandins) and it has a cardioprotective effect (directly via Bradykinin action, indirectly via endothelium-derived relaxing factor action).
  • Synonyms

    HMWK light chain; Kininogen 1; Kininogen 1 light chain; KNG; KNG1;

  • Native Proteins
  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Transfected Stable Cell Lines
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • Human Cells
  • Human plasma
  • Human Plasma
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Mouse
  • Wheat Germ
  • Yeast
  • C
  • His
  • DYKDDDDK
  • GST
  • His (Fc)
  • Avi
  • His|GST
  • His|T7
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • T7|His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human KNG1-1844H Native Human Kininogen 1 Human plasma N/A
Human KNG1-3179H Active Recombinant Human KNG1 protein, His-tagged HEK293 His Gln19-Ser644
Human KNG1-6746H Recombinant Human KNG1 protein, His-tagged E.coli His Ser390~Ser644 (Accession # P01042)
Human KNG1-70H Recombinant Human KNG1 protein, T7/His-tagged E.coli T7/His
Human KNG1-049H Recombinant Human KNG1 Protein HEK293 N/A
Human KNG1-2284HCL Recombinant Human KNG1 cell lysate Human Cell N/A
Human KNG1-5787HF Recombinant Full Length Human KNG1 Protein, GST-tagged In Vitro Cell Free System GST 427 amino acids
Human KNG1-2582H Recombinant Human KNG1 Protein (Gln19-Ser427), C-His tagged Mammalian cells C-His Gln19-Ser427
Human KNG1-18H Native Human Kininogen, LMW Human Plasma N/A
Human KNG1-4853H Recombinant Human KNG1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human KNG1-4366H Recombinant Human KNG1 Protein (Arg58-Leu176), N-His tagged E.coli N-His Arg58-Leu176
Human KNG1-60H Recombinant Human KNG1 Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
Human KNG1-4902H Recombinant Human KNG1 Protein, GST-tagged Wheat Germ GST
Human KNG1-5288H Recombinant Human KNG1 protein, His-tagged E.coli His 390-639aa
Human KNG1-820H Recombinant Human KNG1 Protein HEK293 644
Human KNG1-687H Recombinant Human KNG1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human KNG1-375H Recombinant Human KNG1 (LMW) protein, His-tagged HEK293 His 409
Human CAB11572MH Mouse Anti-Human Kininogen 1 Monoclonal Antibody Mouse N/A
Human KNG1-29146TH Native Human KNG1 Human Plasma N/A
Human KNG1-29338TH Native Human KNG1 Human Plasma N/A
Mouse Kng1-909M Active Recombinant Mouse Kng1 Protein, His-tagged Mammalian cells His Glu21-Ser661
Mouse Kng1-3300M Active Recombinant Mouse Kng1 protein(Glu21-Ser480), His-tagged HEK293 C-His Glu21-Ser480
Mouse Kng1-6747M Recombinant Mouse Kng1 protein, His-tagged E.coli His Glu22~Arg379 (Accession # O08677)
Mouse Kng1-1818M Recombinant Mouse Kng1 protein, His & GST-tagged E.coli His/GST Arg268~Arg540
Mouse KNG1-2276MCL Recombinant Mouse KNG1 cell lysate Human Cell N/A
Mouse Kng1-4893M-B Recombinant Mouse Kng1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Kng1-4893M Recombinant Mouse Kng1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Kng1-1819R Recombinant Rat Kng1 protein, His & GST-tagged E.coli His/GST Leu214~Asp475
Rat Kng1-6748R Recombinant Rat Kng1 protein, His & T7-tagged E.coli His/T7 Gln19~Arg380 (Accession # P08934)
Rat KNG1-1435R Recombinant Rat KNG1 Protein (390-639 aa), His-tagged Yeast His 390-639 aa
Rat Kng1-91R Rat Thiostatin Reference Standard N/A
Zebrafish KNG1-1506Z Recombinant Zebrafish KNG1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • KNG1 Related Articles
  • KNG1 Related Research Area

KNG1 involved in several pathways and played different roles in them. We selected most pathways KNG1 participated on our site, such as Complement and coagulation cascades, which may be useful for your reference. Also, other proteins which involved in the same pathway with KNG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Complement and coagulation cascadesF9;BDKRB2;SERPINA1A;PLAT;C5AR1;F2;KLKB1;F13B;C4BPA

KNG1 has several biochemical functions, for example, cysteine-type endopeptidase inhibitor activity, heparin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KNG1 itself. We selected most functions KNG1 had, and list some proteins which have the same functions with KNG1. You can find most of the proteins on our site.

Function Related Protein
cysteine-type endopeptidase inhibitor activityCST9;CST2;SERPINB4;CST8;CST5;CST9L;WFDC2;CST4;AHSG2
heparin bindingCXCL13;SLIT3;WISP3;CTGFB;FGFBP1;SLIT2;CXCL10;NELL2;APP
protein bindingLPHN1;PTPRZ1;TRAPPC6A;RAB26;NAT8B;CHST13;POLG2;KCNH2;HGF
receptor bindingABCA1;PPY;MPV17L;TDGF1;HRG;CAPRIN2;INHA;APOL2;NCR3
zinc ion bindingRABIF;MMP24;BFAR;RXRG;PDXK;TRIM2;RBM4.1;APOBEC1;TRAF5

KNG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KNG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of KNG1.

Ance; C1QBP; F12; KLKB1; Lamc1; Lamb1; Lama1; Lama5; Lamb2; p29991-pro_0000037946; d-mannose

Lieb, W; Chen, MH; et al. Genome-Wide Meta-Analyses of Plasma Renin Activity and Concentration Reveal Association With the Kininogen 1 and Prekallikrein Genes. CIRCULATION-CARDIOVASCULAR GENETICS 8:131-U278(2015).
Bruzelius, M; Bottai, M; et al. Predicting venous thrombosis in women using a combination of genetic markers and clinical risk factors. JOURNAL OF THROMBOSIS AND HAEMOSTASIS 13:219-227(2015).
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Reviews
07/26/2021

    Utilizing protein reagents reduces material consumption in experiments, resulting in resource conservation.

    05/09/2019

      The usage method of protein reagents is flexible, adapting to various experimental requirements.

      01/06/2018

        The precise and reliable results achieved by employing protein reagents make them highly favored in scientific research.

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