KPNA1
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Official Full Name
karyopherin alpha 1 (importin alpha 5)
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Overview
Recombination activating proteins RAG1 and RAG2 regulate and mediate V(D)J recombination, the process by which genes for immunoglobulins and T-cell receptors are generated. Several other ubiquitously expressed proteins are thought to be recruited in the recombination process. Among these are the genes affected in severe combined immune deficiency and genes involved in ds-DNA break repair. The protein encoded by this gene interacts with RAG1 and may play a role in V(D)J recombination. Two transcript variants, one protein-coding and the other not, have been found for this gene. -
Synonyms
KPNA1; karyopherin alpha 1 (importin alpha 5); importin subunit alpha-1; IPOA5; NPI 1; RCH2; SRP1; SRP1-beta; importin alpha 5; importin-alpha-S1; RAG cohort protein 2; nucleoprotein interactor 1; karyopherin subunit alpha-1; recombination activating gene;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rhesus Macaque
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- His|T7
- Myc
- DDK
- MYC
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- KPNA1 Related Gene Family
- KPNA1 Related Research Area
KPNA1 involved in several pathways and played different roles in them. We selected most pathways KPNA1 participated on our site, such as Influenza A, which may be useful for your reference. Also, other proteins which involved in the same pathway with KPNA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Influenza A | STAT1;DNAJC3;HSPA1L;MAPK13;TNFSF10;CXCL8;AKT1;HLA-DMB;MAP2K4 |
KPNA1 has several biochemical functions, for example, nuclear localization sequence binding, protein binding, protein transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KPNA1 itself. We selected most functions KPNA1 had, and list some proteins which have the same functions with KPNA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| nuclear localization sequence binding | KPNA6;TNPO2;KPNA7;KPNA4;KPNA1;IPO4;KPNB1;TNPO3;NFKBIA |
| protein binding | PDCD5;BAZ1B;TOMM70A;DYDC1;ZBTB8A;Car8;TLR3;ATP6V1B2;HEMK1 |
| protein transporter activity | KPNA4;AP2B1;KPNA5;TNPO3;SOSTDC1B;ITGB1BP1;IPO7;KPNA6;CALCR |
KPNA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KPNA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of KPNA1.
ANP32B; TAF9; NUP50; USP1; CLK4; EBNA1
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