LAMA4
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Official Full Name
laminin, alpha 4
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Overview
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the alpha chain isoform laminin, alpha 4. The domain structure of alpha 4 is similar to that of alpha 3, both of which resemble truncated versions of alpha 1 and alpha 2, in that approximately 1,200 residues at the N-terminus (domains IV, V and VI) have been lost. Laminin, alpha 4 contains the C-terminal G domain which distinguishes all alpha chains from the beta and gamma chains. The RNA analysis from adult and fetal tissues revealed developmental regulation of expression, however, the exact function of laminin, alpha 4 is not known. Tissue-specific utilization of alternative polyA-signal has been described in literature. Alternative splicing results in multiple transcript variants encoding distinct isoforms. -
Synonyms
LAMA4; laminin, alpha 4; laminin subunit alpha-4; LAMA3; laminin alpha 4 chain; LAMA4*-1; DKFZp686D23145;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Zebrafish
- CHO
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | LAMA4-6952H | Active Recombinant Human Laminin α4 | CHO | N/A | ||
Human | LAMA4-6956H | Recombinant Human Laminin α4, GST-Tagged | E.coli | GST | ||
Human | LAMA4-6953H | Recombinant Human Laminin α4, GST-tagged | Wheat Germ | GST | ||
Human | LAMA4-69527H | Recombinant Human Laminin α4, His-tagged | E.coli | His | ||
Human | LAMA4-967HCL | Recombinant Human LAMA4 cell lysate | N/A | |||
Human | LAMA4-213H | Recombinant Human LAMA4 Protein, His-tagged | E.coli | His | Ile832~Lys1039 | |
Human | LAMA4-276HF | Recombinant Full Length Human Lamininα4 Protein, GST-tagged | In Vitro Cell Free System | GST | 1 a.a. - 120 a.a. | |
Mouse | LAMA4-6954M | Active Recombinant Mouse Laminin α4, His-tagged | Mammalian cells | His | ||
Mouse | LAMA4-8932M | Recombinant Mouse LAMA4 Protein | Mammalian Cell | His | ||
Mouse | Lama4-214M | Recombinant Mouse Lama4 Protein, His-tagged | E.coli | His | Gln102~Thr234 | |
Mouse | LAMA4-4980M-B | Recombinant Mouse LAMA4 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | LAMA4-4980M | Recombinant Mouse LAMA4 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Zebrafish | LAMA4-3605Z | Recombinant Zebrafish LAMA4 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- LAMA4 Related Articles
- LAMA4 Related Research Area
LAMA4 involved in several pathways and played different roles in them. We selected most pathways LAMA4 participated on our site, such as PIK-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with LAMA4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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PIK-Akt signaling pathway | ITGA3;PIK3R5;PPP2R5E;IFNA7;BCL2;TLR4;NRAS;FOXO3;IFNA14 |
Focal adhesion | AKT3A;MYL9;DIAPH1;IGF1;HRASA;PTENA;PARVB;FLNC;PDGFA |
ECM-receptor interaction | ITGA6;Reln;LAMA3;ITGA4;ITGA2;GP9;TNW;COL1A2;THBS1 |
African trypanosomiasis | F2RL1;APOA1;IFNG;GNAQ;IDO2;IL1B;MYD88;IDO1;FAS |
Toxoplasmosis | PDPK1;IKBKB;TLR4;HLA-DOA;MAPK1;CASP8;PIK3CG;TAB2;HLA-DRA |
Amoebiasis | SERPINB2;CD14;CSF2;IL12A;LAMA3;LAMB4;PRKCA;GNA15;IL10 |
Pathways in cancer | FIGF;BIRC8;HSP90AA1;RET;PRKCA;RASGRP3;HSP90AB1;BRCA2;RASSF1 |
Small cell lung cancer | PTEN;BIRC7;LAMC1;TRAF4;XIAP;LAMA3;FN1;IKBKG;RARB |
LAMA4 has several biochemical functions, for example, extracellular matrix structural constituent, protein binding, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LAMA4 itself. We selected most functions LAMA4 had, and list some proteins which have the same functions with LAMA4. You can find most of the proteins on our site.
Function | Related Protein |
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extracellular matrix structural constituent | IMPG1;COL1A1;COL3A1;FBLN1;OPTC;COL1A1B;ELNA;ELN;LAMA4 |
protein binding | SERPINC1;LSM11;HNRNPH1;EIF4EBP3L;RPL27A;SYNJ2BP;KIAA1737;CNOT10;CXXC11 |
receptor binding | PLAT;PLG;GLA;IL1RAPL1;NRG2;PKD2;PECI;EHHADH;WNT5B |
LAMA4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LAMA4 here. Most of them are supplied by our site. Hope this information will be useful for your research of LAMA4.
TP53; DAG1; 40038273; GAPDH; PTN; APC; SUMO2; EEF1A1; UNC119; FHL1; TUBB2A; RIF1; ATF7IP; COPS6; UBR1; BRD7; RTN4; ZHX1; MED31
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