lama4
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  • Official Full Name
  • laminin, alpha 4
  • Background
  • Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the alpha chain isoform laminin, alpha 4. The domain structure of alpha 4 is similar to that of alpha 3, both of which resemble truncated versions of alpha 1 and alpha 2, in that approximately 1,200 residues at the N-terminus (domains IV, V and VI) have been lost. Laminin, alpha 4 contains the C-terminal G domain which distinguishes all alpha chains from the beta and gamma chains. The RNA analysis from adult and fetal tissues revealed developmental regulation of expression, however, the exact function of laminin, alpha 4 is not known. Tissue-specific utilization of alternative polyA-signal has been described in literature. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
  • Synonyms
  • LAMA4; laminin, alpha 4; laminin subunit alpha-4; LAMA3; laminin alpha 4 chain; LAMA4*-1; DKFZp686D23145
Cat.#:LAMA4-213HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LAMA4 Protein, His-tagged
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Cat.#:Lama4-214MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Lama4 Protein, His-tagged
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Cat.#:LAMA4-69527HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Laminin α4, His-tagged
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Cat.#:LAMA4-6952HTag:N/A
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Laminin α4
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Cat.#:LAMA4-6953HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human Laminin α4, GST-tagged
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Cat.#:LAMA4-6956HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Laminin α4, GST-Tagged
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Cat.#:LAMA4-6954MTag:His
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Laminin α4, His-tagged
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Cat.#:LAMA4-8932MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse LAMA4 Protein
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Cat.#:LAMA4-3605ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish LAMA4
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Cat.#:LAMA4-967HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human LAMA4 cell lysate
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Involved Pathway

LAMA4 involved in several pathways and played different roles in them. We selected most pathways LAMA4 participated on our site, such as PIK-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with LAMA4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
PIK-Akt signaling pathway
FGFR1; PPP2R5A; AKT2; PRKAA1; FGF13; THBS4; FGF11; RPS6; GNG13; FLT1
Focal adhesion
XIAP; MYL9A; COL27A1; COL6A2; PPP1R12B; MAPK9; VEGFAB; VASP; PTK2AB; PTK2AA
ECM-receptor interaction
FN1; SDC4; COL6A2; TNW; ITGB1B.2; ITGB4; THBS4; ITGB1A; COL6A3; COL2A1
African trypanosomiasis
PLCB4; GNAQ; PRKCG; APOL1; IL6; MYD88; THOP1; TNF; PLCB3; FAS
Toxoplasmosis
TNF; MAP2K3; GNAO1; Toxoplasma Gondii Major Surface Antigen P30; MAPK3; ALOX5; CYCS; IRAK1; Toxoplasma Gondii Microneme Protein MIC3; HSPA1A
Amoebiasis
SERPINB1A; SERPINB1C; Itgam&Itgb2; SERPINB4; SERPINB13; SERPINB1; ARG2; COL1A1; SERPINB6B; COL1A2
Pathways in cancer
WNT11; RELA; LPAR5; NFKB1; TGFBR2; TRAF1; SFPI1; PTGER2; AGTR1A; ARHGEF1
Small cell lung cancer
AKT2; BIRC2; ITGA3; PTGS2; PIK3CB; ITGB1; TRAF2; CCNE2; LAMC1; BIRC7

Protein Function

LAMA4 has several biochemical functions, for example, extracellular matrix structural constituent, protein binding, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LAMA4 itself. We selected most functions LAMA4 had, and list some proteins which have the same functions with LAMA4. You can find most of the proteins on our site.
Function
Related Protein
Function extracellular matrix structural constituent
Related Protein LAMB1; EFEMP2; FBN2B; COL1A1; COL24A1; ELNA; LAMC1; COL2A1B; BGN; COL4A1
Function protein binding
Related Protein NACC2; TCEANC2; SNX5; ZNF624; PTPRO; ROR2; PHC3; NPY2R; FZD5; ANK2
Function receptor binding
Related Protein HSD17B4; ECI2; CADM2; P2RX7; PVRL4; FGF24; ANKRD13C; WNT2BB; CADM4; SERPINE1

Interacting Protein

LAMA4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LAMA4 here. Most of them are supplied by our site. Hope this information will be useful for your research of LAMA4.
TP53; DAG1; 40038273; GAPDH; PTN; APC; SUMO2; EEF1A1; UNC119; FHL1; TUBB2A; RIF1; ATF7IP; COPS6; UBR1; BRD7; RTN4; ZHX1; MED31

LAMA4 Related Articles

Zhao, W; Han, HB; et al. Suppression of lung cancer cell invasion and metastasis by connexin43 involves the secretion of follistatin-like 1 mediated via histone acetylation. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 43:1459-1468(2011).
Huang, XH; Ji, GQ; et al. LAMA4, highly expressed in human hepatocellular carcinoma from Chinese patients, is a novel marker of tumor invasion and metastasis. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 134:705-714(2008).
Berfield, AK; Hansen, KM; et al. Rat glomerular mesangial cells require laminin-9 to migrate in response to insulin-like growth factor binding protein-5. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 291:C589-C599(2006).
Richards, A; AlImara, L; et al. The complete cDNA sequence of laminin alpha 4 and its relationship to the other human laminin alpha chains. EUROPEAN JOURNAL OF BIOCHEMISTRY 238:813-821(1996).