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LAMTOR2

  • Official Full Name

    late endosomal/lysosomal adaptor, MAPK and MTOR activator 2

  • Overview

    The product of this gene is highly conserved with a mouse protein associated with the cytoplasmic face of late endosomes and lysosomes. The mouse protein interacts with MAPK scaffold protein 1, a component of the mitogen-activated protein kinase pathway. In humans, a mutation in this gene has been associated with a primary immunodeficiency syndrome, and suggests a role for this protein in endosomal biogenesis. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    LAMTOR2; late endosomal/lysosomal adaptor, MAPK and MTOR activator 2; roadblock domain containing 3 , ROBLD3; ragulator complex protein LAMTOR2; ENDAP; endosomal adaptor protein; MAPBPIP; MAPKSP1 adaptor protein; MAPKSP1AP; mitogen activated protein bindi;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human LAMTOR2-552H Recombinant Human late endosomal/lysosomal adaptor, MAPK and MTOR activator 2, His-tagged E.coli His
Human LAMTOR2-31332TH Recombinant Human LAMTOR2, His-tagged E.coli His 125 amino acids
Human LAMTOR2-6975H Recombinant Human LAMTOR2, His tagged E.coli His
Human LAMTOR2-2257HCL Recombinant Human ROBLD3 293 Cell Lysate HEK293 N/A
Mouse LAMTOR2-8944M Recombinant Mouse LAMTOR2 Protein Mammalian Cell His
Mouse Lamtor2-3750M Recombinant Mouse Lamtor2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse LAMTOR2-4987M-B Recombinant Mouse LAMTOR2 Protein Pre-coupled Magnetic Beads HEK293
Mouse LAMTOR2-4987M Recombinant Mouse LAMTOR2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque LAMTOR2-2459R Recombinant Rhesus monkey LAMTOR2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque LAMTOR2-2280R Recombinant Rhesus Macaque LAMTOR2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque LAMTOR2-2280R-B Recombinant Rhesus Macaque LAMTOR2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish LAMTOR2-983Z Recombinant Zebrafish LAMTOR2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • LAMTOR2 Related Articles

LAMTOR2 involved in several pathways and played different roles in them. We selected most pathways LAMTOR2 participated on our site, such as ARMS-mediated activation, Axon guidance, Cellular responses to stress, which may be useful for your reference. Also, other proteins which involved in the same pathway with LAMTOR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ARMS-mediated activationPEA15A;DUSP7;FGF20A;NRG3;MARK3;LAMTOR2;SLC14A2;EGF;DLG4
Axon guidanceCLASP1;DOCK1;EFNA3;COL9A1B;TRPC4;PEA15A;NEFLB;EPHA4A;ABLIM1
Cellular responses to stressRBB4L;CHMP4B;CBX4;RPS19BP1;MAPKAPK2B;DNAJC7;TNIK;RRAGB;ATG4A
Cytokine Signaling in Immune systemEIF4E;UBE2L6;GBP5;TRIM38;ARIH1L;EIF4G2;KBTBD7;DUSP4;EIF4G2A
DAP12 interactionsRASGRP1;DUSP2;GRAP2B;SPRED1;JAK1;SPTBN1;KIR3DS1;ADRBK1;WDR83
DAP12 signalingTRAT1;NEFLB;PEBP1;PTPRA;SPTA1;DUSP5;NRG4;WDR83;NRG2A
Developmental BiologyFGF10B;DUSP5;SPRED3;FRS2B;LGI1A;COL6A2;CSNK2A2;SPTBN1;SCN3B
Downstream signal transductionFRS3;SPRED1;PAQR3B;LAMTOR2;PTPRA;CNKSR1;IL17RD;DAB2IPB;SPTBN1

LAMTOR2 has several biochemical functions, for example, contributes_to guanyl-nucleotide exchange factor activity, protein binding, contributes_to protein complex scaffold. Some of the functions are cooperated with other proteins, some of the functions could acted by LAMTOR2 itself. We selected most functions LAMTOR2 had, and list some proteins which have the same functions with LAMTOR2. You can find most of the proteins on our site.

Function Related Protein
contributes_to guanyl-nucleotide exchange factor activityEIF2B2;LAMTOR3;LAMTOR2;EIF2B3;ALS2;EIF2B1;LAMTOR1;C7orf59;HBXIP
protein bindingSPPL2B;MMP20;TJAP1;ACTN2;C2orf88;DDL-2;MIER1;SCGB2A2;BTF3
contributes_to protein complex scaffoldHBXIP;LAMTOR3;LAMTOR2;C7orf59;LAMTOR1

LAMTOR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LAMTOR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of LAMTOR2.

LAMTOR3; LAMTOR1

Sparber, F; Tripp, CH; et al. The Late Endosomal Adaptor Molecule p14 (LAMTOR2) Regulates TGF beta 1-Mediated Homeostasis of Langerhans Cells. JOURNAL OF INVESTIGATIVE DERMATOLOGY 135:119-129(2015).
Fichera, M; Barone, R; et al. Familial 1q22 microduplication associated with psychiatric disorders, intellectual disability and late-onset autoimmune inflammatory response. MOLECULAR CYTOGENETICS 7:-(2014).
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