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LARS

  • Official Full Name

    leucyl-tRNA synthetase

  • Overview

    This gene encodes a cytosolic leucine-tRNA synthetase, a member of the class I aminoacyl-tRNA synthetase family. The encoded enzyme catalyzes the ATP-dependent ligation of L-leucine to tRNA(Leu). It is found in the cytoplasm as part of a multisynthetase complex and interacts with the arginine tRNA synthetase through its C-terminal domain. Alternatively spliced transcript variants of this gene have been found; however, their full-length nature is not known.
  • Synonyms

    LARS; leucyl-tRNA synthetase; leucyl-tRNA synthetase, cytoplasmic; FLJ10595; FLJ21788; HSPC192; LARS1; leucine tRNA ligase 1; cytoplasmic; LEUS; RNTLS; Leucine tRNA ligase; Cytoplasmic leucyl tRNA synthetase; Cytosolic leucyl tRNA synthetase; hr025Cl; HSPC 192; KIAA1352; LARS 1; Leucine translase; Leucyl tRNA synthetase cytoplasmic; LeuRS; LRS; PIG 44; PIG44; Proliferation inducing gene 44; OTTHUMP00000223912; OTTHUMP00000223913; leucine-tRNA ligase; leucine--tRNA ligase; proliferation-inducing gene 44; cytosolic leucyl-tRNA synthetase; cytoplasmic leucyl-tRNA synthetase; leucine tRNA ligase 1, cytoplasmic;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • E.coli
  • HEK293
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human LARS-509H Recombinant Human LARS, GST-tagged E.coli GST C-350aa
Human LARS-8208H Recombinant Human LARS protein, His & T7-tagged E.coli His/T7 Gly260~Glu509 (Accession # Q9P2J5)
Human LARS-262H Recombinant Human LARS Mammalian Cell His
Human LARS-3336H Recombinant Human LARS Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human LARS-3336H-B Recombinant Human LARS Protein Pre-coupled Magnetic Beads HEK293
Mouse Lars-1730M Recombinant Mouse Lars Protein, His&GST-tagged E.coli N-His&GST Met1-Ala321
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • LARS Related Articles

LARS involved in several pathways and played different roles in them. We selected most pathways LARS participated on our site, such as Aminoacyl-tRNA biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with LARS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Aminoacyl-tRNA biosynthesisWARS2;IARS;GATC;FARS2;WARS;CARS;TARS2;HARS;TARSL2

LARS has several biochemical functions, for example, ATP binding, aminoacyl-tRNA editing activity, leucine-tRNA ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LARS itself. We selected most functions LARS had, and list some proteins which have the same functions with LARS. You can find most of the proteins on our site.

Function Related Protein
ATP bindingERN2;KIF18A;CSNK2A2;FGFR3;MELK;FAM120B;SMC1AL;AK5;AK7
aminoacyl-tRNA editing activityDTD2;AARS;IARS2;PRORSD1;VARS2;IARS;DTD1;VARS;LARS
leucine-tRNA ligase activityLARS2;LARS
NOT methionine-tRNA ligase activityAIMP1;LARS
protein bindingECSIT;PFDN2;LAMTOR3;ZNF473;FOXO4;SMAD6;SEMA3E;TES;MME

LARS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LARS here. Most of them are supplied by our site. Hope this information will be useful for your research of LARS.

RRAGD; RARS; RPTOR; gag

Ma, LL; O'Byrne, PM; et al. The pharmacological modulation of allergen-induced asthma. INFLAMMOPHARMACOLOGY 21:113-124(2013).
Muller, A; Lehmann, I; et al. Increased incidence of allergic sensitisation and respiratory diseases due to mould exposure: Results of the Leipzig Allergy Risk children Study (LARS). INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH 204:363-365(2002).
  • Q&As
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