lcmt2
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  • Official Full Name
  • leucine carboxyl methyltransferase 2
  • Background
  • The protein encoded by this intronless gene belongs to the highly variable methyltransferase superfamily. This gene is the inferred homolog of the Saccharomyces cerevisiae carboxymethyltransferase gene PPM2 that is essential for the synthesis of the hypermodified guanosine Wybutosine (yW).
  • Synonyms
  • LCMT2; leucine carboxyl methyltransferase 2; KIAA0547; MGC9534; PPM2; tRNA yW synthesizing protein 4; TYW4; tRNA-yW synthesizing protein 4; tRNA-Wybutosine-synthesizing protein 4; p21WAF1/CIP1 promoter-interacting protein; FLJ51321
Cat.#:LCMT2-125HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human LCMT2, His-tagged
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Cat.#:LCMT2-188HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human LCMT2 protein, GST-tagged
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Cat.#:LCMT2-522HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LCMT2, His-tagged
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Cat.#:LCMT2-9001MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse LCMT2 Protein
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Cat.#:LCMT2-3367RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat LCMT2 Protein
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Cat.#:LCMT2-6936ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish LCMT2
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Cat.#:LCMT2-4802HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human LCMT2 293 Cell Lysate
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Involved Pathway

LCMT2 involved in several pathways and played different roles in them. We selected most pathways LCMT2 participated on our site, such as Gene Expression, Synthesis of wybutosine at G37 of tRNA(Phe), tRNA modification in the nucleus and cytosol, which may be useful for your reference. Also, other proteins which involved in the same pathway with LCMT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Gene Expression
ZNF334; TEAD1A; CSTF3; HNRNPA0A; SNRNP48; CHD4A; HNRNPF; ZNF434; SIN3B; TXNL4A
Synthesis of wybutosine at G37 of tRNA(Phe)
TYW1; TYW3; LCMT2; TYW5; TRMT12; TRMT5
tRNA modification in the nucleus and cytosol
OSGEP; KIAA1456; LBH; PUS7; ADAT3; LAGE3; TRMT112; PUS1; TRMT1; TRMT61A
tRNA processing
LCMT2; TSEN15; TRMT11; TP53RK; POP1; KIAA1456; MANEA; TYW5; QTRTD1; TYW1
wybutosine biosynthesis
TYW3; TYW1; LCMT2

Protein Function

LCMT2 has several biochemical functions, for example, S-adenosylmethionine-dependent methyltransferase activity, protein binding, tRNA methyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LCMT2 itself. We selected most functions LCMT2 had, and list some proteins which have the same functions with LCMT2. You can find most of the proteins on our site.
Function
Related Protein
Function S-adenosylmethionine-dependent methyltransferase activity
Related Protein TPMT.2; PRMT7; AS3MT; MEPCE; C6orf211; TPMT.1; RRP8; COQ5; NOP2; LSM1
Function protein binding
Related Protein PIR; PTMA; PDLIM4; C10orf96; DHX58; RP9; PGK1; APEX1; VRK1; TAF12
Function tRNA methyltransferase activity
Related Protein TRMT10B; FBLL1; PRDM13; METTL21A; PRDM11; TRMT13; DIMT1; METTL21D; NDUFAF5; METTL7B

Interacting Protein

LCMT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LCMT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of LCMT2.
AP4M1; VPS26A; SNCA; Ctnnbl1

LCMT2 Related Articles

Kalhor, HR; Luk, K; et al. Protein phosphatase methyltransferase 1 (Ppm1p) is the sole activity responsible for modification of the major forms of protein phosphatase 2A in yeast. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 395:239-245(2001).