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LFNG

Official Full Name

LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Overview

This gene is a member of the fringe gene family which also includes radical and manic fringe genes. They all encode evolutionarily conserved glycosyltransferases that act in the Notch signaling pathway to define boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. This gene product is predicted to be a single-pass type II Golgi membrane protein but it may also be secreted and proteolytically processed like the related proteins in mouse and Drosophila (PMID: 9187150). Mutations in this gene have been associated with autosomal recessive spondylocostal dysostosis 3. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms

LFNG; LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; lunatic fringe (Drosophila) homolog , lunatic fringe homolog (Drosophila); beta-1,3-N-acetylglucosaminyltransferase lunatic fringe; SCDO3; 3-N-acetylglucosaminyltransferase lunatic fringe; Beta-1; Beta-13-N-acetylglucosaminyltransferase lunatic fringe; LFNG_HUMAN; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; OTTHUMP00000201070; OTTHUMP00000201071; OTTHUMP00000201072; OTTHUMP00000201073;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Gallus gallus (Chicken)
Human
Mus musculus (Mouse)
Rat
Zebrafish

Source

E.coli
E.coli expression system
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	LFNG-29854TH	Recombinant Human LFNG	Wheat Germ	N/A	250 amino acids	Inquiry
Human	LFNG-983HCL	Recombinant Human LFNG cell lysate		N/A		Inquiry
Human	LFNG-2140H	Recombinant Human LFNG Protein (1-250 aa), GST-tagged	E.coli	GST	1-250 aa	Inquiry
Human	LFNG-286HF	Recombinant Full Length Human LFNG Protein	In Vitro Cell Free System		250 amino acids	Inquiry
Rat	LFNG-3384R	Recombinant Rat LFNG Protein	Mammalian Cell	His		Inquiry
Rat	LFNG-3040R	Recombinant Rat LFNG Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	LFNG-3040R-B	Recombinant Rat LFNG Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Gallus gallus (Chicken)	RFL4497GF	Recombinant Full Length Chicken Beta-1,3-N-Acetylglucosaminyltransferase Lunatic Fringe(Lfng) Protein, His-Tagged	E.coli expression system	His	Full Length (1-363)	Inquiry
Mus musculus (Mouse)	RFL9829MF	Recombinant Full Length Mouse Beta-1,3-N-Acetylglucosaminyltransferase Lunatic Fringe(Lfng) Protein, His-Tagged	E.coli expression system	His	Full Length (1-378)	Inquiry
Zebrafish	LFNG-8607Z	Recombinant Zebrafish LFNG	Mammalian Cell	His		Inquiry
Chicken	LFNG-6508C	Recombinant Chicken LFNG	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
LFNG Related Research Area
LFNG Related Signal Pathway

LFNG involved in several pathways and played different roles in them. We selected most pathways LFNG participated on our site, such as Other types of O-glycan biosynthesis, Notch signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with LFNG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Other types of O-glycan biosynthesis	POFUT1;PLOD3;C3orf64;ST6GAL1;GXYLT1B;B3GALTLA;B3GALTL;POGLUT1;ST6GAL2
Notch signaling pathway	HDAC2;CTBP1;HER9;MARK2;LNX1;KAT2A;RBPJB;CTBP2A;DVL3A

LFNG has several biochemical functions, for example, O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity, metal ion binding, molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by LFNG itself. We selected most functions LFNG had, and list some proteins which have the same functions with LFNG. You can find most of the proteins on our site.

Function	Related Protein
O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity	RFNG;MFNG;LFNG
metal ion binding	FHL1A;NOX1;PRIM2;TAE1;ZNF511;ZBTB4;ZNF581;LOXL2B;ZIC1
molecular_function	ARHGEF37;C14orf2;APOL4;TMEM240;BSDC1;GM10487;CSN3;METRN;NPAP1

LFNG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LFNG here. Most of them are supplied by our site. Hope this information will be useful for your research of LFNG.

Notch Pathway