lgi1
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  • Official Full Name
  • leucine-rich, glioma inactivated 1
  • Background
  • This gene is rearranged as a result of translocations in glioblastoma cell lines. The protein contains a hydrophobic segment representing a putative transmembrane domain with the amino terminus located outside the cell. It also contains leucine-rich repeats with conserved cysteine-rich flanking sequences. This gene is predominantly expressed in neural tissues and its expression is reduced in low grade brain tumors and significantly reduced or absent in malignant gliomas. Mutations in this gene result in autosomal dominant lateral temporal epilepsy. [provided by RefSeq, Jul 2008]
  • Synonyms
  • LGI1; leucine-rich, glioma inactivated 1; EPT; ETL1; ADLTE; ADPAEF; ADPEAF; IB1099; EPITEMPIN; leucine-rich glioma-inactivated protein 1; epitempin-1;
Cat.#:LGI1-9069MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse LGI1 Protein
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Cat.#:LGI1-3393RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat LGI1 Protein
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Cat.#:LGI1-2503RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey LGI1 Protein, His-tagged
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Cat.#:LGI1-3447CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken LGI1
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Cat.#:LGI1-4759HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human LGI1 293 Cell Lysate
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Involved Pathway

LGI1 involved in several pathways and played different roles in them. We selected most pathways LGI1 participated on our site, such as Developmental Biology, LGI-ADAM interactions, which may be useful for your reference. Also, other proteins which involved in the same pathway with LGI1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Developmental Biology
DOCK1; SHB; EFNB2A; HIF3A; CLTA; CLTB; TRIO; ARPC2; STX1B; FGF10B
LGI-ADAM interactions
LGI3; CACNG2B; LGI1B; LGI1A; STX1B; LGI1; ADAM22; CACNG8A; LGI2; LGI2A

Protein Function

LGI1 has several biochemical functions, for example, protein binding, receptor binding, NOT receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LGI1 itself. We selected most functions LGI1 had, and list some proteins which have the same functions with LGI1. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein PRKCE; FGR; MEIS1; IQCE; KIF2A; PDGFB; FAM184A; PHC3; PAWR; ABCB1
Function receptor binding
Related Protein LHB; FGF12B; PVRL1B; DIAPH1; BAAT; BMP2; CRH; HCK; ACOX2; HFE
Function NOT receptor binding
Related Protein ITK; STYK1; LGI1; BMX; TEC; BTK; TXK

LGI1 Related Articles

Huda, S; Wong, SH; et al. An 11-year retrospective experience of antibodies against the voltage-gated potassium channel (VGKC) complex from a tertiary neurological centre. JOURNAL OF NEUROLOGY 262:418-424(2015).
Agazzi, P; Bien, CG; et al. Over 10-year follow-up of limbic encephalitis associated with anti-LGI1 antibodies. JOURNAL OF NEUROLOGY 262:469-470(2015).