limk2
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  • Official Full Name
  • LIM domain kinase 2
  • Background
  • LIM kinases (LIMK1 and LIMK2) are serine/threonine kinases that have two zinc finger motifs, known as LIM motifs, in their amino-terminal regulatory domains (1). LIM kinases are involved in actin cytoskeletal regulation downstream of Rho-family GTPases, P
  • Synonyms
  • LIMK2; LIM domain kinase 2
Cat.#:LIMK2-382HTag:GST/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LIMK2 Protein, GST/His-tagged
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Cat.#:LIMK2-9109MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse LIMK2 Protein
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Cat.#:LIMK2-3412RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat LIMK2 Protein
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Cat.#:LIMK2-6672CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken LIMK2
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Cat.#:LIMK2-761ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish LIMK2
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Cat.#:LIMK2-4737HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human LIMK2 293 Cell Lysate
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Cat.#:LIMK2-4738HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human LIMK2 293 Cell Lysate
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Involved Pathway

LIMK2 involved in several pathways and played different roles in them. We selected most pathways LIMK2 participated on our site, such as Axon guidance, Fc gamma R-mediated phagocytosis, Regulation of actin cytoskeleton, which may be useful for your reference. Also, other proteins which involved in the same pathway with LIMK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Axon guidance
EPHB4A; EPHA8; ARHGEF12; RHOB; HBEGF; SEMA7A; RHOAE; ROCK1; RGMB; SPNA2
Fc gamma R-mediated phagocytosis
FCGR2A; AMPH; MYO10; WAS; cgr2b; WASF3; HCK; GSN; AKT2; RAC2
Regulation of actin cytoskeleton
ITGA7; ITGB3; GNA13A; ITGA3; MAP2K2A; FGF2; ITGA2; FGF14; SLC9A1; MAP2K1

Protein Function

LIMK2 has several biochemical functions, for example, ATP binding, protein binding, protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LIMK2 itself. We selected most functions LIMK2 had, and list some proteins which have the same functions with LIMK2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein STK25A; NEK1; PDK4; DNAH5; CCT8L2; IRAK4; BMPR1BB; ADCY7; GATB; ATAD3A
Function protein binding
Related Protein SNRPB; PRH1; NCOA3; CALM2; LMF2; TRMT2B; PREP; CCND1; FEN1; NPHP3
Function protein heterodimerization activity
Related Protein HIST3H2BB; GABRR1; BTBD11; DRAP1; HIST2H2AA4; APOA2; SOX8; TFAP2E; PPP2R4; HIST1H2BA
Function protein serine/threonine kinase activity
Related Protein HIPK3; MAST4; PINK1; TAOK2; TTBK1; RPS6KA2; ROCK1; PRKCBA; RPS6KB1B; MAP2K3
Function zinc ion binding
Related Protein LNPEP; VAT1L; ITGB1BP2; TRIM64C; NR5A5; TRIM35-21; ZGLP1; MMP9; IGHMBP2; PCGF5

Interacting Protein

LIMK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LIMK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of LIMK2.
HSP90AB1; CDC37; PARD3; q5ngc7_fratt; HIPK3; linkable pd173955 analogue; bosutinib; crizotinib; CALU; DNAJA2; BAG2; LMNA; HSPB1; ATP1A1; CDK4; EEF2; HSP90B1; DNAJA1; EMD

LIMK2 Related Articles

Acevedo, K; Moussi, N; et al. LIM kinase 2 is widely expressed in all tissues. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 54:487-501(2006).
Foletta, VC; Moussi, N; et al. LIM kinase 1, a key regulator of actin dynamics, is widely expressed in embryonic and adult tissues. EXPERIMENTAL CELL RESEARCH 294:392-405(2004).
Toshima, J; Ohashi, K; et al. Identification and characterization of a novel protein kinase, TESK1, specifically expressed in testicular germ cells. JOURNAL OF BIOLOGICAL CHEMISTRY 270:31331-31337(1995).