LIMS1
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Official Full Name
LIM and senescent cell antigen-like domains 1
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Overview
The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010] -
Synonyms
LIMS1; LIM and senescent cell antigen-like domains 1; PINCH; PINCH1; PINCH-1; LIM and senescent cell antigen-like-containing domain protein 1; renal carcinoma antigen NY-REN-48; particularly interesting new Cys-His protein 1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- His|T7
- N/A
- N
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | LIMS1-29952TH | Recombinant Human LIMS1 | Wheat Germ | N/A | 325 amino acids |
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| Human | LIMS1-4736HCL | Recombinant Human LIMS1 293 Cell Lysate | HEK293 | N/A |
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| Human | LIMS1-284HF | Recombinant Full Length Human LIMS1 Protein | In Vitro Cell Free System | 325 amino acids |
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| Human | LIMS1-1873H | Recombinant Human LIMS1 protein, GST-tagged | E.coli | GST | 1-325 aa | |
| Human | LIMS1-1507H | Recombinant Human LIMS1 protein, His & T7-tagged | E.coli | His/T7 | Ala68~Cys303 (Accession # P48059) |
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| Human | LIMS1-4448H | Recombinant Human LIMS1 Protein (Ala68-Cys303), N-His tagged | E.coli | N-His | Ala68-Cys303 |
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| Mouse | LIMS1-9110M | Recombinant Mouse LIMS1 Protein | Mammalian Cell | His |
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| Mouse | LIMS1-5087M-B | Recombinant Mouse LIMS1 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Mouse | LIMS1-2784M | Recombinant Mouse LIMS1 Protein (2-325 aa), His-tagged | Insect Cell | His | 2-325 aa |
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| Mouse | LIMS1-2655M | Recombinant Mouse LIMS1 Protein (2-325 aa) | E.coli | N/A | 2-325 aa |
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| Mouse | LIMS1-5087M | Recombinant Mouse LIMS1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Zebrafish | LIMS1-2996Z | Recombinant Zebrafish LIMS1 | Mammalian Cell | His |
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| Chicken | LIMS1-1161C | Recombinant Chicken LIMS1 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- LIMS1 Related Articles
- LIMS1 Related Research Area
LIMS1 involved in several pathways and played different roles in them. We selected most pathways LIMS1 participated on our site, such as Cell junction organization, Cell-Cell communication, Cell-extracellular matrix interactions, which may be useful for your reference. Also, other proteins which involved in the same pathway with LIMS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell junction organization | JUP;CD151;ANG;CDH6;PARVB;CLDN7;CDH5;CDH2;CDH9 |
| Cell-Cell communication | CDH6;CLDN20;JUPA;CLDN4;CADM2A;PVRL1A;KIRRELB;KIRREL3L;CDH18 |
| Cell-extracellular matrix interactions | PARVB;FBLIM1;FERMT2;ITGB1B.1;RSU1;LIMS1;TESK1 |
| Regulation of cytoskeletal remodeling and cell spreading by IPP complex components | TESK1;RSU1;LIMS1;PARVB |
LIMS1 has several biochemical functions, for example, protein binding, protein kinase binding, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LIMS1 itself. We selected most functions LIMS1 had, and list some proteins which have the same functions with LIMS1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | GATA2;PPP3R2;IL1A;USP18;SHC3;ZNF202;C21orf2;SRA1;CSRP2BP |
| protein kinase binding | DUSP3;PRKACA;SPRY2;AKAP5;ELAVL1;ATP1A1;GATA6;PRDX3;FOXM1 |
| zinc ion binding | ING4;ADH1B;PDLIM3A;MMP14B;PDZRN4;ISL2;PRKCA;KDM2BA;TRIM41 |
LIMS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LIMS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LIMS1.
ILK; RSU1; NCK2; Ilk; Hoxa1
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