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LINGO1

  • Official Full Name

    leucine rich repeat and Ig domain containing 1

  • Overview

    Leucine rich repeat and Ig domain containing 1 also known as LINGO-1 is a protein which in humans is encoded by the LINGO1 gene.
  • Synonyms

    LINGO1; leucine rich repeat and Ig domain containing 1; leucine rich repeat neuronal 6A , LRRN6A; leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1; FLJ14594; LERN1; leucine rich repeat neuronal 6A; leucine-rich repeat neuronal protein 1; leucine-rich repeat neuronal protein 6A; leucine-rich repeat and immunoglobilin domain-containing protein 1; LRRN6A; UNQ201; MGC17422;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
  • E. coli
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Yeast
  • Flag
  • hFc
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human LINGO1-4728HCL Recombinant Human LINGO1 293 Cell Lysate HEK293 N/A
Human LINGO1-001H Recombinant Human LINGO1 Protein, His-tagged E. coli His
Human LINGO1-2099H Recombinant Human LINGO1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human LINGO1-4356H Recombinant Human LINGO1 protein, His-tagged E.coli His 42-561aa
Human LINGO1-385H Recombinant Human LINGO1 protein, hFc-tagged HEK293 hFc Asp409-Thr556
Human LINGO1-1297H-B Recombinant Human LINGO1 Protein Pre-coupled Magnetic Beads HEK293
Human LINGO1-349HFL Recombinant Full Length Human LINGO1 Protein, C-Flag-tagged Mammalian cells Flag
Human LINGO1-386H Recombinant Human LINGO1 protein, His-tagged HEK293 His Asp409-Thr556
Human LINGO1-1297H Recombinant Human LINGO1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human LINGO1-485H Recombinant Human LINGO1 protein, His-tagged HEK293 His Thr40-Thr556
Mouse LINGO1-9121M Recombinant Mouse LINGO1 Protein Mammalian Cell His
Mouse LINGO1-1143M Recombinant Mouse LINGO1 Protein (37-555 aa), His-tagged E.coli His 37-555 aa
Mouse Lingo1-3789M Recombinant Mouse Lingo1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse LINGO1-5095M-B Recombinant Mouse LINGO1 Protein Pre-coupled Magnetic Beads HEK293
Mouse LINGO1-5095M Recombinant Mouse LINGO1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse LINGO1-2333M Recombinant Mouse LINGO1 Protein (37-555 aa), His-tagged Yeast His 37-555 aa
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) RFL35595XF Recombinant Full Length Xenopus Tropicalis Leucine-Rich Repeat And Immunoglobulin-Like Domain-Containing Nogo Receptor-Interacting Protein 1(Lingo1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (28-606)
Chicken LINGO1-2182C Recombinant Chicken LINGO1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • LINGO1 Related Articles
  • LINGO1 Related Research Area

LINGO1 involved in several pathways and played different roles in them. We selected most pathways LINGO1 participated on our site, such as Axonal growth inhibition (RHOA activation), BDNF signaling pathway, Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with LINGO1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Axonal growth inhibition (RHOA activation)OMG;LINGO1B;RTN4A;LINGO1;RTN4;ARHGEF1B
BDNF signaling pathwayEGR2;EIF4E;EIF4EBP1;CNR1;CDH2;EEF2;YBX1;EIF2S1;FRS3
Signal TransductionAMOTL2B;LGR5;OPHN1;CRABP2B;IRBP;IQGAP3;AKR1C6;CSHL1;ARHGAP26
Signalling by NGFRTN4;DNAL4;LINGO1B;RIT2;PRDM4;PCSK5;PCSK6;DNAL4B;LINGO1
p75 NTR receptor-mediated signallingLINGO1;AATF;RTN4;RTN4A;OMG;LINGO1B;ARHGEF1B;PRDM4
p75NTR regulates axonogenesisOMG;ARHGEF1B;RTN4;LINGO1;RTN4A;LINGO1B

LINGO1 has several biochemical functions, for example, epidermal growth factor receptor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LINGO1 itself. We selected most functions LINGO1 had, and list some proteins which have the same functions with LINGO1. You can find most of the proteins on our site.

Function Related Protein
epidermal growth factor receptor bindingSNX4;GRB2;RNF126;EFEMP1;ATXN2;HBEGF;AREG;LINGO1;AGR2
protein bindingNCALD;STRADA;HSPD1;TUBA1C;GNPDA1;VASN;BBS10;KARS;ITGB3

LINGO1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LINGO1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LINGO1.

TRIM27; GOLGA2; SPAG5; EFEMP2; FBXW7; KRTAP4-12

Dubessy, AL; Zujovic, V; et al. Biotherapies in multiple sclerosis: A step toward remyelination and neuroprotection?. REVUE NEUROLOGIQUE 170:770-778(2014).
Knier, B; Hemmer, B; et al. Novel monoclonal antibodies for therapy of multiple sclerosis. EXPERT OPINION ON BIOLOGICAL THERAPY 14:503-513(2014).
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